Pharmacological targeting of ICAM-1 signaling in brain endothelial cells: potential for treating neuroinflammation (Q36166116)

12 August 2017

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title

Pharmacological targeting of ICAM-1 signaling in brain endothelial cells: potential for treating neuroinflammation (English)

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12 August 2017

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3

John Greenwood

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author name string

Patric Turowski

series ordinal

1

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12 August 2017

Peter Adamson

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2

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12 August 2017

publication date

1 February 2005

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Cellular and Molecular Neurobiology

12 August 2017

published in

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12 August 2017

volume

25

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12 August 2017

issue

1

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12 August 2017

page(s)

153-170

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Cross-linking of brain endothelial intercellular adhesion molecule (ICAM)-1 induces association of ICAM-1 with detergent-insoluble cytoskeletal fraction

12 August 2017

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ICAM-1-coupled cytoskeletal rearrangements and transendothelial lymphocyte migration involve intracellular calcium signaling in brain endothelial cell lines.

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Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration

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Intercellular Adhesion Molecule (ICAM)-1, But Not ICAM-2, Activates RhoA and Stimulates c-fos and rhoA Transcription in Endothelial Cells

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Contrasting effects of anti-adhesion molecule therapy in experimental allergic encephalomyelitis and Theiler's murine encephalomyelitis

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12 December 2020

Occludin modulates transepithelial migration of neutrophils.

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12 December 2020

Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a rho-dependent pathway

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12 December 2020

Endothelial signaling in leukocyte transmigration

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12 December 2020

Lymphocyte migration into the CNS modelled in vitro: roles of LFA-1, ICAM-1 and VLA-4.

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Interferon-beta directly influences monocyte infiltration into the central nervous system.

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Lovastatin treatment decreases mononuclear cell infiltration into the CNS of Lewis rats with experimental allergic encephalomyelitis

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12 December 2020

ICAM-1-coupled signaling pathways in astrocytes converge to cyclic AMP response element-binding protein phosphorylation and TNF-alpha secretion

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12 December 2020

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The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

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Interferon β-1a downregulates TNFα-induced intercellular adhesion molecule 1 expression on brain microvascular endothelial cells through a tyrosine kinase-dependent pathway

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12 December 2020

Encephalitogenic T cells use LFA-1 for transendothelial migration but not during capture and initial adhesion strengthening in healthy spinal cord microvessels in vivo

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12 December 2020

Reactive oxygen species enhance the migration of monocytes across the blood-brain barrier in vitro

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12 December 2020

Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels

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12 December 2020

Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility

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12 December 2020

Strain specific variation in cytokine regulated ICAM-1 expression by rat brain-endothelial cells

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12 December 2020

Neutrophil-induced changes in the biomechanical properties of endothelial cells: roles of ICAM-1 and reactive oxygen species

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12 December 2020

Cellular activation through the ligation of intercellular adhesion molecule-1

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12 December 2020

Brain microvascular endothelial cells and leukocytes derived from patients with multiple sclerosis exhibit increased adhesion capacity

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12 December 2020

Anti-adhesion molecule therapy in experimental autoimmune encephalomyelitis

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12 December 2020

Occludin as a possible determinant of tight junction permeability in endothelial cells

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12 December 2020

Cell adhesion and polarity during immune interactions

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12 December 2020

T cell interaction with ICAM-1-deficient endothelium in vitro: transendothelial migration of different T cell populations is mediated by endothelial ICAM-1 and ICAM-2

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ERM proteins and merlin: integrators at the cell cortex

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12 December 2020

In vitro adhesion and migration of T lymphocytes across monolayers of human brain microvessel endothelial cells: regulation by ICAM-1, VCAM-1, E-selectin and PECAM-1.

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12 December 2020

The role of PECAM-1 (CD31) in leukocyte emigration: studies in vitro and in vivo

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12 December 2020

Cross-linking of ICAM-1 induces co-signaling of an oxidative burst from mononuclear leukocytes

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12 December 2020

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12 December 2020

Inhibition of experimental autoimmune encephalomyelitis by a tyrosine kinase inhibitor

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12 December 2020

Immunomodulation of experimental autoimmune encephalomyelitis in the Lewis rats by Lovastatin

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12 December 2020

The blood-brain barrier and the inflammatory response.

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12 December 2020

E-selectin and ICAM-1 are incorporated into detergent-insoluble membrane domains following clustering in endothelial cells

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12 December 2020

Endothelial cell E- and P-selectin and vascular cell adhesion molecule-1 function as signaling receptors

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12 December 2020

Basic principles of immunological surveillance of the normal central nervous system

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12 December 2020

Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.

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12 December 2020

Src homology domain 2-containing tyrosine phosphatase 2 associates with intercellular adhesion molecule 1 to regulate cell survival

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12 December 2020

Mammalian MAP kinase signalling cascades

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12 December 2020

Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways.

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12 December 2020

Statins as potential therapeutic agents in neuroinflammatory disorders

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12 December 2020

Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin

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12 December 2020

Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate

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12 December 2020

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

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12 December 2020

Interactions of intercellular adhesion molecule-1 with fibrinogen

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12 December 2020

Expression of vascular addressins and ICAM-1 by endothelial cells in the spinal cord during chronic relapsing experimental allergic encephalomyelitis in the Biozzi AB/H mouse

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12 December 2020

Leukocyte extravasation: chemokine transport and presentation by the endothelium

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12 December 2020

Signaling through intercellular adhesion molecule 1 (ICAM-1) in a B cell lymphoma line. The activation of Lyn tyrosine kinase and the mitogen-activated protein kinase pathway

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12 December 2020

Intercellular adhesion molecule 1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells.

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12 December 2020

Clustering the adhesion molecules VLA‐4 (CD49d/CD29) in Jurkat T cells or VCAM‐1 (CD106) in endothelial (ECV 304) cells activates the phosphoinositide pathway and triggers Ca2 mobilization

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12 December 2020

A mitogenic action for fibrinogen mediated through intercellular adhesion molecule-1

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12 December 2020

Ligation of ICAM-1 on endothelial cells leads to expression of VCAM-1 via a nuclear factor-kappaB-independent mechanism

1 reference

12 December 2020

Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration

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12 December 2020

The adhesion molecule ICAM-1 and its regulation in relation with the blood-brain barrier

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12 December 2020

Endothelial myosin light chain kinase regulates neutrophil migration across human umbilical vein endothelial cell monolayer.

1 reference

12 December 2020

Leukocyte recruitment in the cerebrospinal fluid of mice with experimental meningitis is inhibited by an antibody to junctional adhesion molecule (JAM).

1 reference

12 December 2020

Cross-linking of intercellular adhesion molecule-1 induces interleukin-8 and RANTES production through the activation of MAP kinases in human vascular endothelial cells

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12 December 2020

Reduced brain edema after traumatic brain injury in mice deficient in P-selectin and intercellular adhesion molecule-1

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12 December 2020

Factors controlling T-cell migration across rat cerebral endothelium in vitro.

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12 December 2020

Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades

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12 December 2020

Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and alpha-actinin

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12 December 2020

ERM proteins and NF2 tumor suppressor: the Yin and Yang of cortical actin organization and cell growth signaling

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12 December 2020

Partial inhibition of AT-EAE by an antibody to ICAM-1: clinico-histological and MRI studies

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12 December 2020

Lung microvascular and arterial endothelial cells differ in their responses to intercellular adhesion molecule-1 ligation

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12 December 2020

Post-translational modifications of p21rho proteins

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12 December 2020

Fibrinogen interactions with ICAM-1 (CD54) regulate endothelial cell survival

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12 December 2020

Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages

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12 December 2020

Signalling to and from tight junctions

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12 December 2020

Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes.

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12 December 2020

Association of the cytoplasmic domain of intercellular-adhesion molecule-1 with glyceraldehyde-3-phosphate dehydrogenase and beta-tubulin

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12 December 2020

Leukocyte traffic in the central nervous system: the participants and their roles

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12 December 2020

The Src-cortactin pathway is required for clustering of E-selectin and ICAM-1 in endothelial cells

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12 December 2020

Antibodies against leukocyte function-associated antigen-1 and against intercellular adhesion molecule-1 together suppress the progression of experimental allergic encephalomyelitis

1 reference

12 December 2020

Endothelial Rho signaling is required for monocyte transendothelial migration

1 reference

12 December 2020

ICAM-1-dependent pathway is not critically involved in the inflammatory process of autoimmune encephalomyelitis or in cytokine-induced inflammation of the central nervous system

1 reference

12 December 2020

Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells

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12 December 2020

Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1.

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12 December 2020

CD54/intercellular adhesion molecule 1 and major histocompatibility complex II signaling induces B cells to express interleukin 2 receptors and complements help provided through CD40 ligation

1 reference

12 December 2020

Protein tyrosine phosphatases in signal transduction.

1 reference

12 December 2020

Adhesion molecules on murine brain microvascular endothelial cells: expression and regulation of ICAM-1 and Lgp 55

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12 December 2020

Cortactin: coupling membrane dynamics to cortical actin assembly

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12 December 2020

ICAM-1 signaling pathways associated with Rho activation in microvascular brain endothelial cells.

1 reference

12 December 2020

Adhesion receptors of the immune system

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12 December 2020

Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm

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12 December 2020

Lymphocyte migration into the central nervous system: implication of ICAM-1 signalling at the blood-brain barrier

1 reference

12 December 2020

Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Effect of pravastatin on outcomes after cardiac transplantation.

1 reference

12 December 2020

Monocyte adhesion and spreading on human endothelial cells is dependent on Rho-regulated receptor clustering

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12 December 2020

Farnesyltransferase inhibitors: antineoplastic mechanism and clinical prospects

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12 December 2020

T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: the cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells

1 reference

12 December 2020

A controlled trial of natalizumab for relapsing multiple sclerosis

1 reference

12 December 2020

Changes in the biomechanical properties of neutrophils and endothelial cells during adhesion

1 reference

12 December 2020

Analysis of the roles of ICAM-1 in neutrophil transmigration using a reconstituted mammalian cell expression model: implication of ICAM-1 cytoplasmic domain and Rho-dependent signaling pathway

1 reference

12 December 2020

Protein kinase C induces actin reorganization via a Src- and Rho-dependent pathway

1 reference

12 December 2020

Amelioration of experimental allergic encephalomyelitis in Lewis rats by lovastatin

1 reference

12 December 2020

A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1

1 reference

12 December 2020

Rho family proteins: coordinating cell responses

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12 December 2020

Lymphocyte adhesion and transendothelial migration in the central nervous system: the role of LFA-1, ICAM-1, VLA-4 and VCAM-1. off

1 reference

12 December 2020

10.1007/S10571-004-1380-0

Identifiers

DOI

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12 August 2017

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