Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options (Q36154689)

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English	Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options	scientific article

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Europe PubMed Central

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12 August 2017

Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options (English)

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lymphoblastic leukemia

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Hans-Jörg Warnatz

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Marie-Laure Yaspo

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Ute Fischer

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Thomas Risch

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Michael Gombert

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Marc Sultan

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Vyacheslav Amstislavskiy

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André Baruchel

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Thies Bartram

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Cengiz Canpolat

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Gunnar Cario

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Dardane Dakaj

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Mauro Delorenzi

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Maria Pamela Dobay

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Cornelia Eckert

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Kebria Hezaveh

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Jessica I Höll

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Sabine Hornhardt

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Peter Husemann

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Priyadarshini Kachroo

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Christian P Kratz

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Anthony V Moorman

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27 July 2015

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Nature Genetics

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47

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9

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1020-1029

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12 August 2017

Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia.

1 reference

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The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

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2 October 2017

Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support.

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2 October 2017

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

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2 October 2017

Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition

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The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function

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Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199

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Leucine-rich repeat-containing G-protein-coupled Receptor 5 marks short-term hematopoietic stem and progenitor cells during mouse embryonic development

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Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth.

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Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia

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RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

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VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.

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Structural Basis for LMO2-Driven Recruitment of the SCL:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets

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The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment

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TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

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Acute lymphoblastic leukaemia

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Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

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The genomic landscape of hypodiploid acute lymphoblastic leukemia

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2 October 2017

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

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Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia

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B-lineage transcription factors and cooperating gene lesions required for leukemia development

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DELLY: structural variant discovery by integrated paired-end and split-read analysis

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Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

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2 October 2017

IKZF1 deletion is an independent predictor of outcome in pediatric acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol

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Lineage tracing reveals Lgr5 stem cell activity in mouse intestinal adenomas

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The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution

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VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing

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Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group

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Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia

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Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).

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Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia

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Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia

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2 October 2017

Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo.

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2 October 2017

SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein

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2 October 2017

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2 October 2017

Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia

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2 October 2017

Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis

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2 October 2017

Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603357

2 October 2017

Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603357

2 July 2018

Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603357

2 July 2018

A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603357

23 September 2018

An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603357

23 September 2018

Lineage classification of childhood acute lymphoblastic leukemia according to the EGIL recommendations: results of the ALL-BFM 2000 trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603357

23 September 2018

Biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5: potential targets of BAL development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603357

23 September 2018

Xenografts of highly resistant leukemia recapitulate the clonal composition of the leukemogenic compartment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603357

23 September 2018

Prognostic impact of t(1;19)/TCF3–PBX1in childhood acute lymphoblastic leukemia in the context of Berlin–Frankfurt–Münster-based protocols

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603357

23 September 2018

Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603357

23 September 2018

Specific induction of CD33 expression by E2A-HLF: the first evidence for aberrant myeloid antigen expression in ALL by a fusion transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603357

23 September 2018

Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603357

23 September 2018

Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603357

23 September 2018

GSEA-P: a desktop application for Gene Set Enrichment Analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603357

23 September 2018

Hypercalcemia in childhood acute lymphoblastic leukemia: frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603357

23 September 2018

Two novel germline KRAS mutations: expanding the molecular and clinical phenotype

1 reference

https://api.crossref.org/works/10.1038/NG.3362

21 January 2018

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

1 reference

https://api.crossref.org/works/10.1038/NG.3362

21 January 2018

Guidelines for the design and statistical analysis of experiments using laboratory animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/26214592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The E2A-HLF oncogenic fusion protein acts through Lmo2 and Bcl-2 to immortalize hematopoietic progenitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26214592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/NG.3362

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

ResearchGate publication ID

0 references

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