Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis (Q36117770)

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25 December 2019

title

Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis (English)

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25 December 2019

9

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25 December 2019

author name string

Vivien R Sutton

1

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25 December 2019

Nigel J Waterhouse

2

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25 December 2019

Kylie A Browne

3

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25 December 2019

Karin Sedelies

4

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25 December 2019

Annette Ciccone

5

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25 December 2019

Desiree Anthony

6

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25 December 2019

Aulikki Koskinen

7

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25 December 2019

Arno Mullbacher

8

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25 December 2019

language of work or name

English

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publication date

5 February 2007

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25 December 2019

published in

Journal of Cell Biology

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25 December 2019

volume

176

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25 December 2019

issue

4

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25 December 2019

page(s)

425-433

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Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation

25 December 2019

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A family with Papillon-Lefevre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity

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2 October 2017

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Functional significance of the perforin/granzyme cell death pathway

2 October 2017

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2 October 2017

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Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

2 October 2017

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Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G

2 October 2017

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Mutations of the cathepsin C gene are responsible for Papillon-Lefèvre syndrome

2 October 2017

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Perforin gene defects in familial hemophagocytic lymphohistiocytosis.

2 October 2017

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Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis

2 October 2017

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Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

2 October 2017

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Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

2 October 2017

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The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes

2 October 2017

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Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

2 October 2017

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How to induce involuntary suicide: the need for dipeptidyl peptidase I.

2 October 2017

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Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction

2 October 2017

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Perforin is essential for control of ectromelia virus but not related poxviruses in mice.

2 October 2017

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In Vitro– and Ex Vivo–derived Cytolytic Leukocytes from Granzyme A × B Double Knockout Mice Are Defective in Granule-mediated Apoptosis but not Lysis of Target Cells

2 October 2017

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Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

2 October 2017

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Expression of human recombinant granzyme A zymogen and its activation by the cysteine proteinase cathepsin C.

2 October 2017

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

2 October 2017

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2 October 2017

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Expression of recombinant human granzyme B. A processing and activation role for dipeptidyl peptidase I.

2 October 2017

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Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.

2 October 2017

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Isolation of two cDNA sequences which encode cytotoxic cell proteases

2 October 2017

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Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes

2 October 2017

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Purified perforin induces target cell lysis but not DNA fragmentation

2 October 2017

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Isolation and complete structure of the lymphocyte serine protease granzyme G, a novel member of the granzyme multigene family in murine cytolytic T lymphocytes. Evolutionary origin of lymphocyte proteases.

2 October 2017

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Cloning of cDNAs that encode human mast cell carboxypeptidase A, and comparison of the protein with mouse mast cell carboxypeptidase A and rat pancreatic carboxypeptidases

2 October 2017

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Genomic organization of the mouse granzyme A gene. Two mRNAs encode the same mature granzyme A with different leader peptides

2 October 2017

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Dual mechanisms of apoptosis induction by cytotoxic lymphocytes.

2 October 2017

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Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene.

2 July 2018

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Novel serine proteases encoded by two cytotoxic T lymphocyte-specific genes

2 July 2018

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cDNA cloning of granzyme C, a granule-associated serine protease of cytolytic T lymphocytes

2 July 2018

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An unusual specificity in the activation of neutrophil serine proteinase zymogens

2 July 2018

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Perforin, a pore-forming protein detectable by monoclonal antibodies, is a functional marker for killer cells

2 July 2018

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A natural killer cell granule protein that induces DNA fragmentation and apoptosis

2 July 2018

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Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

2 July 2018

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The differential contribution of granzyme A and granzyme B in cytotoxic T lymphocyte-mediated apoptosis is determined by the quality of target cells

21 January 2018

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Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans

21 January 2018

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Dipeptidyl peptidase I: importance of progranzyme activation sequences, other dipeptide sequences, and the N-terminal amino group of synthetic substrates for enzyme activity

21 January 2018

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Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice

21 January 2018

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Loss-of-function mutations in cathepsin C in two families with Papillon-Lefèvre syndrome are associated with deficiency of serine proteinases in PMNs

21 January 2018

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Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes

23 September 2018

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Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

21 October 2018

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New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

21 January 2018

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Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I

21 January 2018

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12 December 2020

Activation of recombinant murine cytotoxic cell proteinase-1 requires deletion of an amino-terminal dipeptide

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12 December 2020

New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis

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12 December 2020

A family of serine esterases in lytic granules of cytolytic T lymphocytes

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12 December 2020

Paths of glorious proteases

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12 December 2020

Normal neutrophil function in cathepsin G-deficient mice

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12 December 2020

Production of Fully Active Recombinant Murine Granzyme B in Yeast

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12 December 2020

Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis

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12 December 2020

Caspase dependence of target cell damage induced by cytotoxic lymphocytes

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12 December 2020

Characterization and localization of the genes for mouse proteinase-3 (Prtn3) and neutrophil elastase (Ela2)

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12 December 2020

Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation

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12 December 2020

Impaired cytotoxicity in Papillon-Lefèvre syndrome

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12 December 2020

Identifiers

DOI

10.1083/JCB.200609077

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17283185 AND SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17283185 AND SRC:MED&resulttype=core&format=json

25 December 2019

PubMed publication ID

17283185

1 reference