Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket (Q36117072)

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6 February 2020

title

Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket (English)

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6 February 2020

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Colin James Bell Harvey

1

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6 February 2020

5

Chaitan Khosla

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6 February 2020

author name string

Joseph D Puglisi

2

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6 February 2020

Vijay S Pande

3

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6 February 2020

David E Cane

4

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6 February 2020

language of work or name

English

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publication date

11 July 2012

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Journal of the American Chemical Society

6 February 2020

published in

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6 February 2020

volume

134

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6 February 2020

issue

29

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6 February 2020

page(s)

12259-12265

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Direct Entry to Erythronolides via a Cyclic Bis[Allene]

6 February 2020

cites work

1 reference

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2 October 2017

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Revisiting the structures of several antibiotics bound to the bacterial ribosome

2 October 2017

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Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

2 October 2017

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Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis

2 October 2017

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Recent advances in the medicinal chemistry of novel erythromycin-derivatized antibiotics

2 October 2017

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Various novel erythromycin derivatives obtained by different modifications: recent advance in macrolide antibiotics

2 October 2017

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Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products

2 October 2017

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Total synthesis approaches to natural product derivatives based on the combination of chemical synthesis and metabolic engineering

2 October 2017

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Bioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coli

2 October 2017

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Translation and protein synthesis: macrolides

2 October 2017

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Structural basis for the antibiotic activity of ketolides and azalides

2 October 2017

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Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

2 October 2017

1 reference

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Genetic analysis of erythromycin production in Streptomyces erythreus

2 October 2017

1 reference

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An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

2 October 2017

1 reference

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Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea

2 July 2018

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57 Chloramphenicol acetyltransferase from chloramphenicol-resistant bacteria

2 July 2018

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Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity

2 July 2018

1 reference

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Preparation of erythromycin analogs having functional groups at C-15.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405186

Analysis of covalently bound polyketide intermediates on 6-deoxyerythronolide B synthase by tandem proteolysis-mass spectrometry

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405186

Stereochemical assignment of intermediates in the rifamycin biosynthetic pathway by precursor-directed biosynthesis

23 September 2018

1 reference

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Quantitative polysome analysis identifies limitations in bacterial cell-free protein synthesis

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405186

15-amido erythromycins: synthesis and in vitro activity of a new class of macrolide antibiotics

23 September 2018

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Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance

23 September 2018

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Improved bioconversion of 15-fluoro-6-deoxyerythronolide B to 15-fluoro-erythromycin A by overexpression of the eryK Gene in Saccharopolyspora erythraea

23 September 2018

1 reference

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Precursor-directed production of erythromycin analogs by Saccharopolyspora erythraea

23 September 2018

1 reference

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Cell-free translation reconstituted with purified components

23 September 2018

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Precursor-directed biosynthesis of 16-membered macrolides by the erythromycin polyketide synthase.

23 September 2018

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Regeneration of adenosine triphosphate from glycolytic intermediates for cell-free protein synthesis

23 September 2018

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Precursor-Directed Biosynthesis of Erythromycin Analogs by an Engineered Polyketide Synthase

23 September 2018

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12 December 2020

A novel fluorinated erythromycin antibiotic

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12 December 2020

Dissecting the ribosomal inhibition mechanism of a new ketolide carrying an alkyl-aryl group at C-13 of its lactone ring

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12 December 2020

Precursor-directed biosynthesis of 12-ethyl erythromycin

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12 December 2020

Identifiers

DOI

10.1021/JA304682Q

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22741553 AND SRC:MED&resulttype=core&format=json

6 February 2020

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6 February 2020

PubMed publication ID

22741553

1 reference