Predicting the effect of transcription therapy in hematologic malignancies (Q36109663)

12 August 2017

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title

Predicting the effect of transcription therapy in hematologic malignancies (English)

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12 August 2017

Melnick A

1

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12 August 2017

publication date

1 July 2005

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12 August 2017

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12 August 2017

volume

19

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12 August 2017

issue

7

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12 August 2017

page(s)

1109-1117

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The roles of transcription factors in B lymphocyte commitment, development, and transformation

12 August 2017

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The human BCL6 transgene promotes the development of lymphomas in the mouse

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AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.

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Textbook germinal centers?

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Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

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All-trans retinoic acid in acute promyelocytic leukaemia

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Review: chromatin structural features and targets that regulate transcription

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Diversity in the Sir2 family of protein deacetylases

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Gene regulation by human orthologs of Drosophila heterochromatin protein 1

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DNA methylation patterns and epigenetic memory

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Translating the Histone Code

21 January 2018

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CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation

21 January 2018

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Transcription factor access to chromatin

21 January 2018

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Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression

21 January 2018

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Reading and function of a histone code involved in targeting corepressor complexes for repression

21 January 2018

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Structure and ligand of a histone acetyltransferase bromodomain

21 January 2018

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Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail

21 January 2018

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Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex

21 January 2018

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All in the family: the BTB/POZ, KRAB, and SCAN domains

21 January 2018

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The ETO (MTG8) gene family

21 January 2018

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Role of the histone deacetylase complex in acute promyelocytic leukaemia

21 January 2018

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The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT.

21 January 2018

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ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

21 January 2018

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Histone deacetylases as therapeutic targets in hematologic malignancies

21 January 2018

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Histone deacetylase activity is required for full transcriptional repression by mSin3A

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

The histone deacetylase-3 complex contains nuclear receptor corepressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

The role of MLL in hematopoiesis and leukemia

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Retinoic acid syndrome: manifestations, pathogenesis, and treatment

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

In vivo treatment of human leukemia in a scid mouse model with c-myb antisense oligodeoxynucleotides

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Drug discovery with engineered zinc-finger proteins

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Induction of angiogenesis in a mouse model using engineered transcription factors

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Peptide aptamers: tools for biology and drug discovery

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Targeting fusion protein/corepressor contact restores differentiation response in leukemia cells.

21 January 2018

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Protein transduction: unrestricted delivery into all cells?

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis.

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Identification of small-molecule antagonists that inhibit an activator: coactivator interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Granulocyte-macrophage colony-stimulating factor induces the transcriptional activation of egr-1 through a protein kinase A-independent signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Expression of cyclic adenosine monophosphate response-element binding protein in acute leukemia

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Specific protein redirection as a transcriptional therapy approach for t(8;21) leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Phase II trial of the histone deacetylase inhibitor pivaloyloxymethyl butyrate (Pivanex, AN-9) in advanced non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Treatment of myelodysplastic syndromes with valproic acid alone or in combination with all-trans retinoic acid

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

A phase I trial of depsipeptide (FR901228) in patients with advanced cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Epigenetics in human disease and prospects for epigenetic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

5-aza-2'-deoxycytidine activates the p53/p21Waf1/Cip1 pathway to inhibit cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

5-aza-2'-deoxycytidine upregulates caspase-9 expression cooperating with p53-induced apoptosis in human lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Chronic myelogenous leukemia in nonlymphoid blastic phase: analysis of the results of first salvage therapy with three different treatment approaches for 162 patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Induction of Tumors in Mice by Genomic Hypomethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Mobilization of transposons by a mutation abolishing full DNA methylation in Arabidopsis

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Trichostatin A causes selective loss of DNA methylation in Neurospora

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Translocations involving c-myc and c-myc function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

The t(3;21) fusion product, AML1/Evi-1 blocks AML1-induced transactivation by recruiting CtBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

MLL targets SET domain methyltransferase activity to Hox gene promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Regulation of transcription by a protein methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Human PAD4 regulates histone arginine methylation levels via demethylimination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

The SWI/SNF complex--chromatin and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

Phosphoaminoglycosides inhibit SWI2/SNF2 family DNA-dependent molecular motor domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

21 January 2018

Epigenetics and cancer

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

inferred from DOI database lookup

7 January 2021

based on heuristic

Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2'-deoxycytidine.

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

inferred from DOI database lookup

7 January 2021

based on heuristic

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403777

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.LEU.2403777

1 reference

12 August 2017

1 reference