Tailor-made antibody therapeutics (Q36105050)

12 August 2017

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title

Tailor-made antibody therapeutics (English)

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12 August 2017

Partha S Chowdhury

1

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12 August 2017

Herren Wu

series ordinal

2

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12 August 2017

publication date

1 May 2005

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12 August 2017

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12 August 2017

volume

36

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12 August 2017

issue

1

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12 August 2017

page(s)

11-24

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Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli

12 August 2017

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Increasing the affinity for tumor antigen enhances bispecific antibody cytotoxicity

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Improved breadth and potency of an HIV-1-neutralizing human single-chain antibody by random mutagenesis and sequential antigen panning

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Making antibody fragments using phage display libraries

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Antibody redesign by chain shuffling from random combinatorial immunoglobulin libraries

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Construction and evolution of antibody-phage libraries by DNA shuffling

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Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity

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Ligand-assisted aggregation of proteins. Dimerization of serum amyloid P component by bivalent ligands

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Increased binding affinity enhances targeting of glioma xenografts by EGFRvIII-specific scFv

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Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

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Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

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Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines

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AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line

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Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity

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Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity

7 January 2021

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High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

7 January 2021

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Expression of biological effector functions by immunoglobulin G molecules lacking the hinge region

7 January 2021

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The differential ability of human IgG1 and IgG4 to activate complement is determined by the COOH-terminal sequence of the CH2 domain

7 January 2021

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Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation

7 January 2021

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Amino acid differences in the n-terminus of CH2 influence the relative abilities of IgG2 AND IgG3 to activate complement

7 January 2021

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Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc

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Engineered antibodies with increased activity to recruit complement

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Tumor cell expression of CD59 is associated with resistance to CD20 serotherapy in patients with B-cell malignancies.

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Complement function in mAb-mediated cancer immunotherapy

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Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia

7 January 2021

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Genetic engineering of an immunotoxin to eliminate pulmonary vascular leak in mice

7 January 2021

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Identification of epitopes on a mutant form of Pseudomonas exotoxin using serum from humans treated with Pseudomonas exotoxin containing immunotoxins

7 January 2021

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Enhanced activity of hu14.18-IL2 immunocytokine against murine NXS2 neuroblastoma when combined with interleukin 2 therapy

7 January 2021

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Glycoforms obtained by expression in Pichia pastoris improve cancer targeting potential of a recombinant antibody-enzyme fusion protein

7 January 2021

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Substrate-assisted catalysis: molecular basis and biological significance

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Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism

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Clinical utility of external immunoscintigraphy with the IMMU-4 technetium-99m Fab' antibody fragment in patients undergoing surgery for carcinoma of the colon and rectum: results of a pivotal, phase III trial. The Immunomedics Study Group

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Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial library

7 January 2021

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Covalent disulfide-linked anti-CEA diabody allows site-specific conjugation and radiolabeling for tumor targeting applications

7 January 2021

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"Diabodies": small bivalent and bispecific antibody fragments

7 January 2021

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Phase I study of intravenously applied bispecific antibody in renal cell cancer patients receiving subcutaneous interleukin 2.

7 January 2021

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'Knobs-into-holes' engineering of antibody CH3 domains for heavy chain heterodimerization

7 January 2021

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Remodeling domain interfaces to enhance heterodimer formation

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An efficient route to the production of an IgG-like bispecific antibody

7 January 2021

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Bispecific antibodies targeting cancer cells

7 January 2021

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Di-diabody: a novel tetravalent bispecific antibody molecule by design

7 January 2021

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A trivalent anti-erbB2/anti-CD16 bispecific antibody retargeting NK cells against human breast cancer cells

7 January 2021

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Increasing the serum persistence of an IgG fragment by random mutagenesis.

7 January 2021

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Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences.

7 January 2021

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Engineered human IgG antibodies with longer serum half-lives in primates

7 January 2021

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PEGylated antibodies and antibody fragments for improved therapy: a review

7 January 2021

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Therapeutic antibody fragments with prolonged in vivo half-lives

7 January 2021

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Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity

7 January 2021

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Surface characteristics and the interaction of colloidal particles with mouse peritoneal macrophages

7 January 2021

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Sterically stabilized liposomes

7 January 2021

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Lowering of pI by acylation improves the renal uptake of 99mTc-labeled anti-Tac dsFv: effect of different acylating reagents

7 January 2021

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7 January 2021

Identifiers

DOI

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12 August 2017

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