Gene therapy for obesity (Q36099461)

12 August 2017

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title

Gene therapy for obesity (English)

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12 August 2017

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Sergei Zolotukhin

1

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12 August 2017

language of work or name

English

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publication date

1 March 2005

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Expert Opinion on Biological Therapy

12 August 2017

published in

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12 August 2017

volume

5

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12 August 2017

issue

3

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12 August 2017

page(s)

347-357

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

12 August 2017

cites work

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21 January 2018

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Experimental drugs take aim at obesity

21 January 2018

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Anorectic drugs and vascular disease: the role of voltage-gated K channels

21 January 2018

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The human obesity gene map: the 2003 update

21 January 2018

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Pharmacogenomics: bench to bedside

21 January 2018

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Regulated gene expression in gene therapy.

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Artificial mammalian gene regulation networks-novel approaches for gene therapy and bioengineering

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Dimerizer-regulated gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Comparative genomics of the eukaryotes

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Drug discovery with engineered zinc-finger proteins

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Design and selection of novel Cys2His2 zinc finger proteins

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Differing roles for zinc fingers in DNA recognition: Structure of a six-finger transcription factor IIIA complex

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Zinc finger phage: affinity selection of fingers with new DNA-binding specificities

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

In vitro selection of zinc fingers with altered DNA-binding specificity

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

DNA recognition by Cys2His2 zinc finger proteins

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Toward rules relating zinc finger protein sequences and DNA binding site preferences

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

siRNAs: applications in functional genomics and potential as therapeutics

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

ATP requirements and small interfering RNA structure in the RNA interference pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

A resource for large-scale RNA-interference-based screens in mammals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Adenovirus vector-mediated doxycycline-inducible RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Use of adeno-associated viral vector for delivery of small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Exogenous control of mammalian gene expression through modulation of RNA self-cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Viral vectors for gene transfer: a review of their use in the treatment of human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Virus-based gene delivery systems

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Evaluation of risks related to the use of adeno-associated virus-based vectors.

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Rate limiting steps of AAV transduction and implications for human gene therapy.

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Integration of adeno-associated virus (AAV) and recombinant AAV vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Adeno-associated viruses undergo substantial evolution in primates during natural infections

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Hybrid vectors based on adeno-associated virus serotypes 2 and 5 for muscle-directed gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Generation and characterization of chimeric recombinant AAV vectors

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Cross-dressing the virion: the transcapsidation of adeno-associated virus serotypes functionally defines subgroups

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Efficient and selective AAV2-mediated gene transfer directed to human vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Insertional mutagenesis of the adeno-associated virus type 2 (AAV2) capsid gene and generation of AAV2 vectors targeted to alternative cell-surface receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Incorporation of tumor-targeting peptides into recombinant adeno-associated virus capsids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Adeno-associated virus capsids displaying immunoglobulin-binding domains permit antibody-mediated vector retargeting to specific cell surface receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

In vitro selection of viral vectors with modified tropism: the adeno-associated virus display

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Adeno-associated virus type 2 VP2 capsid protein is nonessential and can tolerate large peptide insertions at its N terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Monitoring of stored and available fuel by the CNS: implications for obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Differential modulation of energy balance by leptin, ciliary neurotrophic factor, and leukemia inhibitory factor gene delivery: microarray deoxyribonucleic acid-chip analysis of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

The clinical uses of leptin

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.

21 January 2018

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https://api.crossref.org/works/10.1517/14712598.5.3.347

AMP-activated protein kinase: a master switch in glucose and lipid metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

ACRP30, a new hormone controlling fat and glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

AdipoQ is a novel adipose-specific gene dysregulated in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Endogenous glucose production is inhibited by the adipose-derived protein Acrp30

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Role of stearoyl-coenzyme A desaturase in lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

The role of uncoupling proteins in the regulation of metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

A humanized system for pharmacologic control of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

A regulatory system for use in gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

The lac operator-repressor system is functional in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Design and in vivo characterization of self-inactivating human and non-human lentiviral expression vectors engineered for streptogramin-adjustable transgene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

Expressing the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14712598.5.3.347

21 January 2018

Identifiers

DOI

10.1517/14712598.5.3.347

1 reference

12 August 2017

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