Induction of nitric-oxide synthase and activation of NF-kappaB by interleukin-12 p40 in microglial cells (Q36091942)

12 August 2017

Induction of nitric-oxide synthase and activation of NF-kappaB by interleukin-12 p40 in microglial cells (English)

1 reference

12 August 2017

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1 reference

K Pahan

1

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12 August 2017

F G Sheikh

2

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12 August 2017

X Liu

3

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12 August 2017

S Hilger

4

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12 August 2017

M McKinney

5

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12 August 2017

T M Petro

6

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12 August 2017

language of work or name

English

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publication date

7 December 2000

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Journal of Biological Chemistry

12 August 2017

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12 August 2017

276

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12 August 2017

11

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12 August 2017

7899-7905

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Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis.

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

Inhibition of phosphatidylinositol 3-kinase induces nitric-oxide synthase in lipopolysaccharide- or cytokine-stimulated C6 glial cells

2 October 2017

1 reference

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The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses

2 October 2017

1 reference

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Production of interleukin-12 and expression of its receptors by murine microglia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

Sphingomyelinase and Ceramide Stimulate the Expression of Inducible Nitric-oxide Synthase in Rat Primary Astrocytes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

Catalysis by a Multiprotein IκB Kinase Complex

2 October 2017

1 reference

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IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

2 October 2017

1 reference

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A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits

2 October 2017

1 reference

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Nitric oxide: a neural messenger

2 October 2017

1 reference

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Development of TH1 CD4 T cells through IL-12 produced by Listeria-induced macrophages

2 October 2017

1 reference

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NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway

2 October 2017

1 reference

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Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

2 October 2017

1 reference

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Evidence for increased nitric oxide production in multiple sclerosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence

2 October 2017

1 reference

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Suppression of arthritis by an inhibitor of nitric oxide synthase

2 October 2017

1 reference

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In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases

2 October 2017

1 reference

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Reactive nitrogen intermediates in human neuropathology: an overview

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

DNA deaminating ability and genotoxicity of nitric oxide and its progenitors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells

2 October 2017

1 reference

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Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures

2 October 2017

1 reference

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Nitric oxide as a secretory product of mammalian cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

Nitric oxide: a pathogenetic factor in autoimmunity

2 October 2017

1 reference

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Cloning and expression of murine IL-12

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

Increased release of interleukin-12p40 in MS: association with intracerebral inflammation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

Inhibitors of protein phosphatase 1 and 2A differentially regulate the expression of inducible nitric-oxide synthase in rat astrocytes and macrophages

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

Inhibition of nitric oxide synthase for treatment of experimental autoimmune encephalomyelitis

27 July 2018

1 reference

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Induction of nitric oxide synthase in rat C6 glioma cells

27 July 2018

1 reference

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Characterization of ameboid microglia isolated from developing mammalian brain.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells

27 July 2018

1 reference

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Decreased interleukin-10 and increased interleukin-12p40 mRNA are associated with disease activity and characterize different disease stages in multiple sclerosis

27 July 2018

1 reference

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Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalitis

23 September 2018

1 reference

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Nuclear Factor-κB Contributes to Excitotoxin-Induced Apoptosis in Rat Striatum

23 September 2018

1 reference

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IL-12 production by central nervous system microglia is inhibited by astrocytes

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

Increasing cAMP attenuates induction of inducible nitric-oxide synthase in rat primary astrocytes

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2041874

Nitric oxide as a potential pathological mechanism in demyelination: its differential effects on primary glial cells in vitro

23 September 2018

1 reference

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Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains

23 September 2018

1 reference

12 December 2020

The IL-12 p40 homodimer as a specific antagonist of the IL-12 heterodimer

1 reference

12 December 2020

Cytokine gene expression in islets and thyroids of BB rats. IFN-gamma and IL-12p40 mRNA increase with age in both diabetic and insulin-treated nondiabetic BB rats

1 reference

12 December 2020

Differential regulation by cytokines of human astrocyte nitric oxide production

1 reference

12 December 2020

Regulation of inducible nitric oxide synthase messenger RNA expression and nitric oxide production by lipopolysaccharide in vivo: the roles of macrophages, endogenous IFN-gamma, and TNF receptor-1-mediated signaling

1 reference

12 December 2020

N-Acetyl Cysteine Inhibits Induction of No Production By Endotoxin or Cytokine Stimulated Rat Peritoneal Macrophages, C6 Glial Cells and Astrocytes

1 reference

12 December 2020

Expression of a constitutively active form of phosphatidylinositol 3-kinase inhibits the induction of nitric oxide synthase in human astrocytes

1 reference

12 December 2020

Expression of a dominant-negative mutant of p21(ras) inhibits induction of nitric oxide synthase and activation of nuclear factor-kappaB in primary astrocytes

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12 December 2020

Murine macrophages stimulated with central and peripheral nervous system myelin or purified myelin proteins release inflammatory products

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12 December 2020

Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide

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Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide

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Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn

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12 December 2020

Identifiers

DOI

10.1074/JBC.M008262200

1 reference

12 August 2017

1 reference

12 August 2017

PubMed publication ID

11110796

1 reference