A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy (Q36086721)

12 August 2017

A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy (English)

1 reference

12 August 2017

1 reference

3

Edward Rockenstein

1 reference

12 August 2017

6

Eliezer Masliah

1 reference

12 August 2017

Brian Spencer

1

1 reference

12 August 2017

Elvira Valera

series ordinal

2

1 reference

12 August 2017

Margarita Trejo-Morales

series ordinal

4

1 reference

12 August 2017

Anthony Adame

series ordinal

5

1 reference

12 August 2017

23 September 2015

1 reference

Molecular Neurodegeneration

12 August 2017

1 reference

12 August 2017

10

1 reference

12 August 2017

48

1 reference

Creative Commons Attribution 4.0 International

12 August 2017

start time

23 September 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageQuant

object named as

ImageQuant

2 references

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4580347/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

cites work

Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy

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The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to α-synuclein inclusions

2 October 2017

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2 October 2017

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Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1.

2 October 2017

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ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo

2 October 2017

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Cognitive impairments in multiple system atrophy of the cerebellar type

2 October 2017

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A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis

2 October 2017

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Resistance of naturally secreted α-synuclein to proteolysis

2 October 2017

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Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo

2 October 2017

1 reference

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Alpha-synuclein mRNA expression in oligodendrocytes in MSA.

2 October 2017

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Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

2 October 2017

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Antidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophy

2 October 2017

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Transmission of multiple system atrophy prions to transgenic mice

2 October 2017

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The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway

2 October 2017

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The function of α-synuclein

2 October 2017

1 reference

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Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy

2 October 2017

1 reference

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Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission

2 October 2017

1 reference

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The role of glia in α-synucleinopathies

2 October 2017

1 reference

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Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Lentivirus Mediated Delivery of Neurosin Promotes Clearance of Wild-type α-Synuclein and Reduces the Pathology in an α-Synuclein Model of LBD

2 October 2017

1 reference

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Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy

2 October 2017

1 reference

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Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes

2 October 2017

1 reference

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Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy

2 October 2017

1 reference

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α-Synuclein in Parkinson disease and other neurodegenerative disorders

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease

2 October 2017

1 reference

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Cell-to-cell transmission of non-prion protein aggregates.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Neurodegeneration in a transgenic mouse model of multiple system atrophy is associated with altered expression of oligodendroglial-derived neurotrophic factors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy

2 October 2017

1 reference

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Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

2 October 2017

1 reference

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Clearance and deposition of extracellular alpha-synuclein aggregates in microglia.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein.

2 October 2017

1 reference

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Novel strategies for Alzheimer's disease treatment

2 October 2017

1 reference

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Targeted delivery of proteins across the blood-brain barrier

2 October 2017

1 reference

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The emergence of proteinase-activated receptor-2 as a novel target for the treatment of inflammation-related CNS disorders

2 October 2017

1 reference

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Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Widespread alterations of alpha-synuclein in multiple system atrophy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

The mammalian low-density lipoprotein receptor family

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Myelin degeneration in multiple system atrophy detected by unique antibodies

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Zyme, a Novel and Potentially Amyloidogenic Enzyme cDNA Isolated from Alzheimer's Disease Brain

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Cellular pathology of multiple system atrophy: a review

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Clinical features and natural history of multiple system atrophy. An analysis of 100 cases.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome).

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Alpha‐Synuclein Stimulation of Astrocytes: Potential Role for Neuroinflammation and Neuroprotection

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Process outgrowth in oligodendrocytes is mediated by CNP, a novel microtubule assembly myelin protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

In vivo analysis of kallikrein-related peptidase 6 (KLK6) function in oligodendrocyte development and the expression of myelin proteins

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Extracellular neurosin degrades α-synuclein in cultured cells.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Production and purification of lentiviral vectors

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Implications of protease M/neurosin in myelination during experimental demyelination and remyelination.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Characterization of proteinase-activated receptor 2 signalling and expression in rat hippocampal neurons and astrocytes

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Selective deficits in the expression of striatal-enriched mRNAs in Huntington's disease.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Human kallikrein 6 activity is regulated via an autoproteolytic mechanism of activation/inactivation.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Transduction of liver cells by lentiviral vectors: analysis in living animals by fluorescence imaging.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Protease M/neurosin mRNA is expressed in mature oligodendrocytes

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580347

Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer's disease and Parkinson's disease

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26394760

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Activation of the kallikrein-kinin system in hemodialysis: role of membrane electronegativity, blood dilution, and pH

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26394760

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/S13024-015-0043-6

1 reference

Dimensions Publication ID

12 August 2017

0 references

1 reference

12 August 2017

PubMed publication ID

26394760

1 reference