Nuclear receptors--a perspective from Drosophila (Q36085690)

12 August 2017

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title

Nuclear receptors--a perspective from Drosophila (English)

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12 August 2017

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Kirst King-Jones

1

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12 August 2017

Carl S Thummel

series ordinal

2

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12 August 2017

publication date

1 April 2005

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12 August 2017

published in

Nature Reviews Genetics

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12 August 2017

volume

6

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12 August 2017

issue

4

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12 August 2017

page(s)

311-323

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The RXR heterodimers and orphan receptors

12 August 2017

cites work

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Nuclear receptors and lipid physiology: opening the X-files

21 January 2018

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Nuclear receptors and the control of metabolism

21 January 2018

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Combinatorial control of gene expression by nuclear receptors and coregulators

21 January 2018

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Control and biochemical nature of the ecdysteroidogenic pathway

21 January 2018

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Functional ecdysone receptor is the product of EcR and Ultraspiracle genes.

21 January 2018

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The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily

21 January 2018

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Molecular mechanisms of developmental timing in C. elegans and Drosophila

21 January 2018

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Essential roles for ecdysone signaling during Drosophila mid-embryonic development

21 January 2018

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Expression and function of the ultraspiracle (usp) gene during development of Drosophila melanogaster

21 January 2018

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The dual role of ultraspiracle, the Drosophila retinoid X receptor, in the ecdysone response

21 January 2018

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Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms

21 January 2018

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Cell-autonomous requirement of the USP/EcR-B ecdysone receptor for mushroom body neuronal remodeling in Drosophila

21 January 2018

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Isoform specific control of gene activity in vivo by the Drosophila ecdysone receptor.

21 January 2018

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EcR isoforms in Drosophila: testing tissue-specific requirements by targeted blockade and rescue

21 January 2018

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Transcription activation by the ecdysone receptor (EcR/USP): identification of activation functions

21 January 2018

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The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation

21 January 2018

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Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects

21 January 2018

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Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor

21 January 2018

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Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation

21 January 2018

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Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle

21 January 2018

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Analyzing the repressive function of ultraspiracle, the Drosophila RXR, in Drosophila eye development

21 January 2018

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Steroid control of longevity in Drosophila melanogaster

21 January 2018

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A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

21 January 2018

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The Drosophila 78C early late puff contains E78, an ecdysone-inducible gene that encodes a novel member of the nuclear hormone receptor superfamily

21 January 2018

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Ecdysteroid regulation and DNA binding properties of Drosophila nuclear hormone receptor superfamily members

21 January 2018

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A molecular mechanism for the stage specificity of the Drosophila prepupal genetic response to ecdysone

21 January 2018

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Characterization of differentially expressed genes in purified Drosophila follicle cells: toward a general strategy for cell type-specific developmental analysis

21 January 2018

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Loss of the ecdysteroid-inducible E75A orphan nuclear receptor uncouples molting from metamorphosis in Drosophila

21 January 2018

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Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

21 January 2018

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DHR 3, an ecdysone-inducible early-late gene encoding a Drosophila nuclear receptor, is required for embryogenesis

21 January 2018

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Temporal profiles of nuclear receptor gene expression reveal coordinate transcriptional responses during Drosophila development

21 January 2018

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DHR3 is required for the prepupal-pupal transition and differentiation of adult structures during Drosophila metamorphosis.

21 January 2018

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Temporal regulation of the mid‐prepupal gene FTZ‐F1: DHR3 early late gene product is one of the plural positive regulators

21 January 2018

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Coordination of Drosophila metamorphosis by two ecdysone-induced nuclear receptors.

21 January 2018

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Modulation of the far-upstream enhancer of the rat alpha-fetoprotein gene by members of the ROR alpha, Rev-erb alpha, and Rev-erb beta groups of monomeric orphan nuclear receptors

21 January 2018

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Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors

21 January 2018

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A functional genomics strategy reveals Rora as a component of the mammalian circadian clock

21 January 2018

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The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator

21 January 2018

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All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta

21 January 2018

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Identification of natural ligands of retinoic acid receptor-related orphan receptor α ligand-binding domain expressed in Sf9 cells––a mass spectrometry approach

21 January 2018

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The Drosophila nuclear receptors FTZ-F1 alpha and FTZ-F1 beta compete as monomers for binding to a site in the fushi tarazu gene

21 January 2018

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LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis

21 January 2018

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Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1.

21 January 2018

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Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress

21 January 2018

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Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

21 January 2018

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The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz.

21 January 2018

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The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors.

21 January 2018

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The nuclear receptor Ftz-F1 and homeodomain protein Ftz interact through evolutionarily conserved protein domains.

21 January 2018

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FTZ-Factor1 and Fushi tarazu interact via conserved nuclear receptor and coactivator motifs

21 January 2018

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Segmentation gene product Fushi tarazu is an LXXLL motif-dependent coactivator for orphan receptor FTZ-F1

21 January 2018

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The Drosophila beta FTZ-F1 orphan nuclear receptor provides competence for stage-specific responses to the steroid hormone ecdysone.

21 January 2018

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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

21 January 2018

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Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

21 January 2018

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Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate.

21 January 2018

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Control of early neurogenesis of the Drosophila brain by the head gap genes tll, otd, ems, and btd.

21 January 2018

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Expression and function of orphan nuclear receptor TLX in adult neural stem cells

21 January 2018

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The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision

21 January 2018

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Tlx, an orphan nuclear receptor, regulates cell numbers and astrocyte development in the developing retina

21 January 2018

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Expression of the transcription factor, tailless, is required for formation of superficial cortical layers

21 January 2018

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Defective limbic system in mice lacking the tailless gene

21 January 2018

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DSF nuclear receptor acts as a repressor in culture and in vivo

21 January 2018

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Dissatisfaction encodes a tailless-like nuclear receptor expressed in a subset of CNS neurons controlling Drosophila sexual behavior

21 January 2018

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dissatisfaction, a gene involved in sex-specific behavior and neural development of Drosophila melanogaster

21 January 2018

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Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent

21 January 2018

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The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates

21 January 2018

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COUP-TFI: an intrinsic factor for early regionalization of the neocortex

21 January 2018

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A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila

21 January 2018

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Genetically distinct cardial cells within the Drosophila heart.

21 January 2018

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Seven-up inhibits ultraspiracle-based signaling pathways in vitro and in vivo.

21 January 2018

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Molecular analysis of the initiation of insect metamorphosis: a comparative study of Drosophila ecdysteroid-regulated transcription

21 January 2018

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The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway

21 January 2018

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Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors

21 January 2018

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Dopamine neuron agenesis in Nurr1-deficient mice

21 January 2018

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Mechanisms of the mouse orphan nuclear receptor TR2-11-mediated gene suppression

21 January 2018

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The DHR78 nuclear receptor is required for ecdysteroid signaling during the onset of Drosophila metamorphosis

21 January 2018

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Bombyx mori orphan receptor, BmHR78: cDNA cloning, testis abundant expression and putative dimerization partner for Bombyx ultraspiracle.

21 January 2018

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Ligand binding and nuclear receptor evolution

21 January 2018

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Evolution of the nuclear receptor superfamily: early diversification from an ancestral orphan receptor

21 January 2018

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PXR, CAR and drug metabolism

21 January 2018

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A nuclear receptor-mediated xenobiotic response and its implication in drug metabolism and host protection.

21 January 2018

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A C. elegans orphan nuclear receptor contributes to xenobiotic resistance

21 January 2018

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Hormonal signals produced by DAF-9/cytochrome P450 regulate C. elegans dauer diapause in response to environmental cues

21 January 2018

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Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

21 January 2018

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Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences

21 January 2018

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Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand

21 January 2018

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To ERR in the estrogen pathway

21 January 2018

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4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gamma

21 January 2018

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Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alpha

21 January 2018

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A triple mutant of the Drosophila ERR confers ligand-induced suppression of activity

21 January 2018

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Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta

21 January 2018

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Tissue-specific gene expression and ecdysone-regulated genomic networks in Drosophila

21 January 2018

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Using nondenaturing mass spectrometry to detect fortuitous ligands in orphan nuclear receptors

21 January 2018

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MicroRNA targets in Drosophila

21 January 2018

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Determinants of target gene specificity for steroid/thyroid hormone receptors

21 January 2018

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21 January 2018

Dating the tree of life

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Update of NUREBASE: nuclear hormone receptor functional genomics

21 January 2018

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Activation of transcription through the ligand-binding pocket of the orphan nuclear receptor ultraspiracle

21 January 2018

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Structure-based analysis of the ultraspiracle protein and docking studies of putative ligands

21 January 2018

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A juvenile hormone agonist reveals distinct developmental pathways mediated by ecdysone-inducible broad complex transcription factors.

21 January 2018

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Hormonal regulation and functional role of Drosophila E75A orphan nuclear receptor in the juvenile hormone signaling pathway

21 January 2018

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Drosophila hormone receptor 38: a second partner for Drosophila USP suggests an unexpected role for nuclear receptors of the nerve growth factor-induced protein B type

21 January 2018

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Ecdysone receptors and their biological actions

31 March 2020

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Phenotypic analysis of EcR-A mutants suggests that EcR isoforms have unique functions during Drosophila development

31 March 2020

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Gene silencing by nuclear orphan receptors

31 March 2020

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Nuclear hormone receptors, metabolism, and aging: what goes around comes around. Transcription factors link lipid metabolism and aging-related processes

31 March 2020

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The E75 ecdysone-inducible gene responsible for the 75B early puff in Drosophila encodes two new members of the steroid receptor superfamily

31 March 2020

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DHR3: a Drosophila steroid receptor homolog

31 March 2020

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X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha

31 March 2020

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Activation and repression of Drosophila alcohol dehydrogenase distal transcription by two steroid hormone receptor superfamily members binding to a common response element

31 March 2020

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Dual role of the Drosophila pattern gene tailless in embryonic termini

31 March 2020

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Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization

31 March 2020

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Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney

31 March 2020

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Isolation, regulation, and DNA-binding properties of three Drosophila nuclear hormone receptor superfamily members

31 March 2020

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Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response

31 March 2020

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Essential roles for the Dhr78 orphan nuclear receptor during molting of the Drosophila tracheal system

31 March 2020

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Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16

31 March 2020

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Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos

31 March 2020

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Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

31 March 2020

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Structural studies on nuclear receptors.

31 March 2020

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Activation of mammalian retinoid X receptors by the insect growth regulator methoprene

31 March 2020

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Juvenile hormone III-dependent conformational changes of the nuclear receptor ultraspiracle

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG1581

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12 August 2017

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