Peroxisome proliferator-activated receptor (PPAR)α and -γ regulate IFNγ and IL-17A production by human T cells in a sex-specific way. (Q36066219)

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2 February 2020

title

Peroxisome proliferator-activated receptor (PPAR)α and -γ regulate IFNγ and IL-17A production by human T cells in a sex-specific way (English)

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2 February 2020

7

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2 February 2020

Alexandre Prat

9

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2 February 2020

author name string

Monan Angela Zhang

1

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2 February 2020

Dorothy Rego

2

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2 February 2020

Marina Moshkova

3

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2 February 2020

Hania Kebir

4

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2 February 2020

Andrzej Chruscinski

5

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2 February 2020

Hoangkim Nguyen

6

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2 February 2020

Frank Z Stanczyk

8

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2 February 2020

Lawrence Steinman

10

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2 February 2020

Shannon E Dunn

11

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2 February 2020

language of work or name

English

0 references

publication date

30 May 2012

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Proceedings of the National Academy of Sciences of the United States of America

2 February 2020

published in

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volume

109

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2 February 2020

issue

24

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2 February 2020

page(s)

9505-9510

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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

2 February 2020

cites work

1 reference

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Nuclear receptors: TH17 cell control from within.

2 October 2017

1 reference

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T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

2 October 2017

1 reference

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Regulation of the Ifng locus in the context of T-lineage specification and plasticity.

2 October 2017

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Inflammation, demyelination, and degeneration - recent insights from MS pathology.

2 October 2017

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Th1 versus Th17: are T cell cytokines relevant in multiple sclerosis?

2 October 2017

1 reference

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T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis

2 October 2017

1 reference

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Sex- and depot-dependent differences in adipogenesis in normal-weight humans

2 October 2017

1 reference

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The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity

2 October 2017

1 reference

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Epigenetics and T helper 1 differentiation

2 October 2017

1 reference

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CD4 T cells: fates, functions, and faults

2 October 2017

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Multiple sclerosis in children: clinical diagnosis, therapeutic strategies, and future directions

2 October 2017

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Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells

2 October 2017

1 reference

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Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3386070

Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3386070

Sex hormones in experimental autoimmune encephalomyelitis: implications for multiple sclerosis

2 October 2017

1 reference

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Androgens alter the cytokine profile and reduce encephalitogenicity of myelin-reactive T cells.

2 October 2017

1 reference

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A gender gap in autoimmunity.

2 October 2017

1 reference

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Gonadal hormones influence the immune response to PLP 139-151 and the clinical course of relapsing experimental autoimmune encephalomyelitis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3386070

Male SJL mice do not relapse after induction of EAE with PLP 139-151.

27 July 2018

1 reference

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Age and sex associations of 40 autoimmune diseases

27 July 2018

1 reference

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Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis.

27 July 2018

1 reference

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Increasing incidence of multiple sclerosis among women in Lorraine, Eastern France

23 September 2018

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Sex differences in PPARgamma expressions in rat adipose tissues

23 September 2018

1 reference

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Sex ratio of multiple sclerosis in Canada: a longitudinal study

23 September 2018

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Cutting edge: CD4 CD25 regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis

23 September 2018

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Gender difference in the non-specific and specific immune response in humans

23 September 2018

1 reference

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Peroxisome proliferator-activated receptor alpha negatively regulates T-bet transcription through suppression of p38 mitogen-activated protein kinase activation

23 September 2018

1 reference

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Sex differences in in vitro pro-inflammatory cytokine production from peripheral blood of multiple sclerosis patients

23 September 2018

1 reference

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17 beta-estradiol inhibits cytokine, chemokine, and chemokine receptor mRNA expression in the central nervous system of female mice with experimental autoimmune encephalomyelitis

23 September 2018

1 reference

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Gender differences in autoimmune demyelination in the mouse: implications for multiple sclerosis

23 September 2018

1 reference

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Self-antigen-induced Th2 responses in experimental allergic encephalomyelitis (EAE)-resistant mice. Th2-mediated suppression of autoimmune disease.

23 September 2018

1 reference

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Consistent production of a higher TH1:TH2 cytokine ratio by stimulated T cells in men compared with women

23 September 2018

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12 December 2020

Sex differences in cytokine responses to myelin peptides in multiple sclerosis

1 reference

12 December 2020

Correlation between interferon production and clinical disease activity in patients with multiple sclerosis

1 reference

12 December 2020

Gender difference in cytokine secretion on immune stimulation with LPS and LTA

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1118458109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22647601 AND SRC:MED&resulttype=core&format=json

2 February 2020

0 references

1 reference

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2 February 2020

PubMed publication ID

22647601

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22647601 AND SRC:MED&resulttype=core&format=json