An open-label phase Ib dose-escalation study of TRC105 (anti-endoglin antibody) with bevacizumab in patients with advanced cancer (Q36061812)

11 August 2017

An open-label phase Ib dose-escalation study of TRC105 (anti-endoglin antibody) with bevacizumab in patients with advanced cancer (English)

1 reference

11 August 2017

1 reference

3

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4 June 2020

Matthew Strother

7

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4 June 2020

author name string

Michael S Gordon

1

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4 June 2020

Francisco Robert

2

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4 June 2020

David S Mendelson

4

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4 June 2020

Jonathan W Goldman

5

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4 June 2020

E Gabriela Chiorean

6

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4 June 2020

Ben K Seon

8

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4 June 2020

William D Figg

9

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4 June 2020

Cody J Peer

10

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4 June 2020

Delia Alvarez

11

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4 June 2020

Bonne J Adams

12

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4 June 2020

Charles P Theuer

13

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4 June 2020

Lee S Rosen

14

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4 June 2020

language of work or name

English

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publication date

26 September 2014

1 reference

11 August 2017

Clinical Cancer Research

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4 June 2020

volume

20

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4 June 2020

issue

23

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4 June 2020

page(s)

5918-5926

1 reference

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Endoglin for targeted cancer treatment

4 June 2020

cites work

1 reference

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Improved survival outcomes in cancer patients with hereditary hemorrhagic telangiectasia

2 October 2017

1 reference

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Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies

2 October 2017

1 reference

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A phase I first-in-human study of TRC105 (Anti-Endoglin Antibody) in patients with advanced cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors

2 October 2017

1 reference

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Basic and Therapeutic Aspects of Angiogenesis

2 October 2017

1 reference

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Endoglin-Targeted Cancer Therapy

2 October 2017

1 reference

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Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival

2 October 2017

1 reference

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Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma

2 October 2017

1 reference

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Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

2 October 2017

1 reference

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Modes of resistance to anti-angiogenic therapy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

Sorafenib in advanced hepatocellular carcinoma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

Endoglin (CD105): a marker of tumor vasculature and potential target for therapy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: proposal of new computed tomography response criteria.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

Correlation between CD105 expression and postoperative recurrence and metastasis of hepatocellular carcinoma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

Hereditary Haemorrhagic Telangiectasia (HHT): genetic and molecular aspects.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

Regional effects of an antivascular endothelial growth factor receptor monoclonal antibody on receptor phosphorylation and apoptosis in human 253J B-V bladder cancer xenografts

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

Both high intratumoral microvessel density determined using CD105 antibody and elevated plasma levels of CD105 in colorectal cancer patients correlate with poor prognosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

CD105 is important for angiogenesis: evidence and potential applications

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

Defective angiogenesis in mice lacking endoglin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study.

2 October 2017

1 reference

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The prognostic value of endoglin (CD105) expression in ovarian carcinoma.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

CD105 expression is an independent predictor of survival in patients with endometrial cancer

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

Endoglin expression is associated with poor oncologic outcome in oral and oropharyngeal carcinoma

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

Prognostic significance of microvessel density determined by an anti-CD105/endoglin monoclonal antibody in astrocytic tumors: comparison with an anti-CD31 monoclonal antibody.

23 September 2018

1 reference

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Antiangiogenic chimeric anti-endoglin (CD105) antibody: pharmacokinetics and immunogenicity in nonhuman primates and effects of doxorubicin.

23 September 2018

1 reference

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Differential vascular and transcriptional responses to anti-vascular endothelial growth factor antibody in orthotopic human pancreatic cancer xenografts

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570619

[New guidelines to evaluate the response to treatment in solid tumors]

23 September 2018

1 reference

12 December 2020

Breast carcinoma: vascular density determined using CD105 antibody correlates with tumor prognosis

1 reference

12 December 2020

Endoglin (CD105) and vascular endothelial growth factor as prognostic markers in esophageal adenocarcinoma

1 reference

12 December 2020

Endoglin (CD105) as a prognostic factor in head and neck squamous cell carcinoma

1 reference

12 December 2020

Comparative evaluation of microvessel density determined by CD34 or CD105 in benign and malignant gastric lesions

1 reference

12 December 2020

Endoglin (CD105) and vascular endothelial growth factor as prognostic markers in prostatic adenocarcinoma

1 reference

12 December 2020

Randomized phase II study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer

1 reference

12 December 2020

10.1158/1078-0432.CCR-14-1143

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25261556 AND SRC:MED&resulttype=core&format=json

release_zvubm5f6qfai5jhdii2nlpfddi

4 June 2020

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/zvubm5f6qfai5jhdii2nlpfddi

24 November 2022

mapped directly with Wikidata item

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4 June 2020

PubMed publication ID

25261556

1 reference