Failure to respond to treatment with typical antipsychotics is not associated with CYP2D6 ultrarapid hydroxylation. (Q36053742)

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31 October 2019

title

Failure to respond to treatment with typical antipsychotics is not associated with CYP2D6 ultrarapid hydroxylation (English)

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31 October 2019

author

Katherine J. Aitchison

1

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31 October 2019

Robin Murray

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31 October 2019

author name string

J Munro

2

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31 October 2019

P Wright

3

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31 October 2019

S Smith

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31 October 2019

A J Makoff

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C Sachse

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P C Sham

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D A Collier

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R W Kerwin

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31 October 2019

language of work or name

English

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publication date

1 September 1999

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British Journal of Clinical Pharmacology

31 October 2019

published in

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volume

48

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issue

3

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31 October 2019

page(s)

388-394

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Involvement of CYP3A4 and CYP2D6 in the metabolism of haloperidol

31 October 2019

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Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

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2 October 2017

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2 October 2017

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Reduced haloperidol: a factor in determining the therapeutic benefit of haloperidol treatment?

2 October 2017

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The Lilly Prize Lecture 1996 ‘Keep on taking the tablets’: pharmacological adaptation during long‐term drug therapy

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Dextromethorphan phenotyping and haloperidol disposition in schizophrenic patients

11 July 2018

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Interconversion between haloperidol and reduced haloperidol in healthy volunteers

11 July 2018

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Disposition of the neuroleptic zuclopenthixol cosegregates with the polymorphic hydroxylation of debrisoquine in humans

11 July 2018

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Oxidation of reduced haloperidol to haloperidol: involvement of human P450IID6 (sparteine/debrisoquine monooxygenase).

11 July 2018

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Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population

11 July 2018

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In-vitro characterization of the cytochrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol.

11 July 2018

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Psychopathological syndromes in the functional psychoses: associations with course and outcome.

23 September 2018

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The CYP2D6 genotype predicts the oral clearance of the neuroleptic agents perphenazine and zuclopenthixol.

23 September 2018

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Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology

23 September 2018

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Haloperidol disposition is dependent on debrisoquine hydroxylation phenotype

21 October 2018

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Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

21 October 2018

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Crossref

https://api.crossref.org/works/10.1046/J.1365-2125.1999.00006.X

In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase

21 January 2018

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12 December 2020

Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings

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12 December 2020

Factors Affecting the Clinical Response to Haloperidol Therapy in Schizophrenia

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12 December 2020

Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype

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12 December 2020

Debrisoquine oxidation phenotype during neuroleptic monotherapy

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12 December 2020

Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population

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12 December 2020

Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine

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12 December 2020

Effect of quinidine on the interconversion kinetics between haloperidol and reduced haloperidol in humans: implications for the involvement of cytochrome P450IID6

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12 December 2020

Genetic polymorphism of cytochrome P450 CYP2D6 in Zimbabwean population

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12 December 2020

D2 dopamine receptor occupancy during low-dose treatment with haloperidol decanoate

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12 December 2020

Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population

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12 December 2020

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis

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12 December 2020

Association between clozapine response and allelic variation in 5-HT2A receptor gene

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12 December 2020

Quinidine inhibits the 7-hydroxylation of chlorpromazine in extensive metabolisers of debrisoquine

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12 December 2020

Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene

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12 December 2020

PCR-based genotyping for duplicated and deleted CYP2D6 genes

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12 December 2020

Effects of the CYP2D6 genotype on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese schizophrenic patients

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12 December 2020

10.1046/J.1365-2125.1999.00006.X

Identifiers

DOI

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31 October 2019

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31 October 2019

PubMed publication ID

10510151

1 reference