The emerging role of the PI3-K-Akt pathway in prostate cancer progression (Q36050987)

11 August 2017

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title

The emerging role of the PI3-K-Akt pathway in prostate cancer progression (English)

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11 August 2017

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Li L

1

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11 August 2017

Ittmann MM

2

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11 August 2017

Ayala G

3

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11 August 2017

Tsai MJ

4

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11 August 2017

Amato RJ

5

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11 August 2017

Wheeler TM

6

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11 August 2017

Miles BJ

7

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11 August 2017

Kadmon D

8

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11 August 2017

Thompson TC

9

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11 August 2017

publication date

1 January 2005

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Prostate Cancer and Prostatic Diseases

11 August 2017

published in

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11 August 2017

volume

8

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11 August 2017

issue

2

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11 August 2017

page(s)

108-118

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Oncogenic kinase signalling

11 August 2017

cites work

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AKT plays a central role in tumorigenesis

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Ten years of protein kinase B signalling: a hard Akt to follow

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Regulation of tumor angiogenesis by integrin-linked kinase (ILK).

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Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation

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PTEN, a unique tumor suppressor gene

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

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Role of serine/threonine protein phosphatase 2A in cancer

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Regulation of protein kinase cascades by protein phosphatase 2A.

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Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes

21 January 2018

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Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.

21 January 2018

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N-Ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase 2A.

21 January 2018

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Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state

21 January 2018

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A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate

21 January 2018

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Phenylbutyrate attenuates the expression of Bcl-X(L), DNA-PK, caveolin-1, and VEGF in prostate cancer cells

21 January 2018

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Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation

21 January 2018

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Caveolin-1 overexpression is an early event in the progression of papillary carcinoma of the thyroid

21 January 2018

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Essential role of caveolae in interleukin-6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells

21 January 2018

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Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Phosphorylated CREB binds specifically to the nuclear protein CBP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Dissection of angiogenic signaling in zebrafish using a chemical genetic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Transition to androgen-independence in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Molecular biology of the androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Role of the Steroid Receptor Coactivator SRC-3 in Cell Growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Novel targets of Akt, p21(Cipl/WAF1), and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Proliferation, cell cycle and apoptosis in cancer

21 January 2018

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TOR, a central controller of cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

PIK3CA is implicated as an oncogene in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

The HER receptor family: a rich target for therapeutic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

The ErbB/HER receptor protein-tyrosine kinases and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Signal transduction and oncogenesis by ErbB/HER receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Chromosomal deletions and tumor suppressor genes in prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

PTEN/MMAC1/TEP1 involvement in primary prostate cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

PTEN/MMAC1 mutations in prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Epigenetic mechanisms for progression of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Alterations of the PPP2R1B gene in human lung and colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the A alpha subunit gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

The protein phosphatase 2A subunit Bgamma gene is identified to be differentially expressed in malignant melanomas by subtractive suppression hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Role of pRB dephosphorylation in cell cycle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Design of peptidomimetics that inhibit the association of phosphatidylinositol 3-kinase with platelet-derived growth factor-beta receptor and possess cellular activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

21 January 2018

1 reference

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Targeting mTOR signaling for cancer therapy

21 January 2018

1 reference

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mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten /- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Rapamycin in transplantation: a review of the evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

Caveolin-1 expression in advanced-stage ovarian carcinoma--a clinicopathologic study

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

7 January 2021

Elevated expression of caveolin-1 in adenocarcinoma of the colon

1 reference

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7 January 2021

Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

7 January 2021

Caveolin-1 expression is associated with high-grade bladder cancer

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

7 January 2021

Upregulation of caveolin-1 and caveolae organelles in Taxol-resistant A549 cells

1 reference

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7 January 2021

Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3K-Akt pathways in ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

7 January 2021

Androgen Receptors in Prostate Cancer

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

7 January 2021

Differential induction of the androgen receptor transcriptional activity by selective androgen receptor coactivators.

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

7 January 2021

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

7 January 2021

10q23.3 loss of heterozygosity is higher in lymph node-positive (pT2-3,N ) versus lymph node-negative (pT2-3,N0) prostate cancer

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

7 January 2021

Analysis of PTEN and the 10q23 region in primary prostate carcinomas

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

7 January 2021

Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms

1 reference

https://api.crossref.org/works/10.1038/SJ.PCAN.4500776

7 January 2021

Identifiers

DOI

10.1038/SJ.PCAN.4500776

1 reference

Dimensions Publication ID

11 August 2017

1025551991

0 references

1 reference