Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity. (Q36044209)

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22 January 2020

title

Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity (English)

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22 January 2020

1

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22 January 2020

author name string

Yatrik M Shah

2

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22 January 2020

Tsutomu Matsubara

3

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22 January 2020

Kristopher W Krausz

4

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22 January 2020

Frank J Gonzalez

5

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22 January 2020

language of work or name

English

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publication date

6 June 2012

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22 January 2020

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22 January 2020

volume

56

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22 January 2020

issue

1

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22 January 2020

page(s)

281-290

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c-Jun N-terminal Kinase (JNK)-dependent Acute Liver Injury from Acetaminophen or Tumor Necrosis Factor (TNF) Requires Mitochondrial Sab Protein Expression in Mice

22 January 2020

cites work

1 reference

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Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching

2 October 2017

1 reference

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Nutritional and hormonal regulation of uncoupling protein 2.

2 October 2017

1 reference

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Role of peroxisome proliferator-activated receptor-alpha in fasting-mediated oxidative stress

2 October 2017

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Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity

2 October 2017

1 reference

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Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management

2 October 2017

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Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury

2 October 2017

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Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice

2 October 2017

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PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators

2 October 2017

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The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha

2 October 2017

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Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation

2 October 2017

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Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure

2 October 2017

1 reference

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The 2006 Bernard B. Brodie Award Lecture. Cyp2e1.

2 October 2017

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Mitochondrial UCPs: new insights into regulation and impact

2 October 2017

1 reference

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Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3.

2 October 2017

1 reference

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Peroxisome proliferator-activated receptor alpha target genes

2 October 2017

1 reference

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The 'novel' 'uncoupling' proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions.

2 October 2017

1 reference

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Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378765

Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting

2 October 2017

1 reference

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Altered Constitutive Expression of Fatty Acid-metabolizing Enzymes in Mice Lacking the Peroxisome Proliferator-activated Receptor α (PPARα)

2 October 2017

1 reference

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Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

2 October 2017

1 reference

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Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378765

Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643

27 July 2018

1 reference

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Oxidative stress-associated rise of hepatic protein glycation increases inflammatory liver injury in uncoupling protein-2 deficient mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378765

Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378765

Mechanism for peroxisome proliferator-activated receptor-alpha activator-induced up-regulation of UCP2 mRNA in rodent hepatocytes

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378765

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378765

Clofibrate pretreatment diminishes acetaminophen's selective covalent binding and hepatotoxicity.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378765

Protection by clofibrate against acetaminophen hepatotoxicity in male CD-1 mice is associated with an early increase in biliary concentration of acetaminophen-glutathione adducts

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22318764

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22318764

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effects of adenoviral overexpression of uncoupling protein-2 and -3 on mitochondrial respiration in insulinoma cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22318764

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/HEP.25645

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22318764 AND SRC:MED&resulttype=core&format=json

22 January 2020

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22 January 2020

PubMed publication ID

22318764

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22318764 AND SRC:MED&resulttype=core&format=json