Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4 CD25 regulatory T cell function. (Q36043724)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703 AND SRC:MED&resulttype=core&format=json

27 January 2020

title

Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4 CD25 regulatory T cell function (English)

1 reference

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27 January 2020

0 references

0 references

1

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27 January 2020

Antony J Cutler

4

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27 January 2020

Mark Peakman

9

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27 January 2020

Timothy Tree

12

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27 January 2020

10

John A Todd

1 reference

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27 January 2020

author name string

Jennifer R Tyler

2

1 reference

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27 January 2020

Jennie H M Yang

3

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27 January 2020

Kate Downes

5

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27 January 2020

Marcin Pekalski

6

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27 January 2020

Gwynneth L Bell

7

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27 January 2020

Sarah Nutland

8

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27 January 2020

Linda S Wicker

11

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27 January 2020

language of work or name

English

0 references

publication date

28 March 2012

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27 January 2020

published in

Journal of Immunology

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27 January 2020

volume

188

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27 January 2020

issue

9

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27 January 2020

page(s)

4644-4653

1 reference

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An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4( ) T cells

27 January 2020

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2 October 2017

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2 October 2017

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2 October 2017

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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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At-risk and recent-onset type 1 diabetic subjects have increased apoptosis in the CD4 CD25 T-cell fraction

2 October 2017

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Foxp3 CD25 CD4 natural regulatory T cells in dominant self-tolerance and autoimmune disease

2 October 2017

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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4 T reg cells

2 October 2017

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2 October 2017

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Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms

2 October 2017

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Homeostatic maintenance of natural Foxp3( ) CD25( ) CD4( ) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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23 September 2018

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23 September 2018

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Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

23 September 2018

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23 September 2018

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23 September 2018

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23 September 2018

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Cutting edge: IL-2 is critically required for the in vitro activation of CD4 CD25 T cell suppressor function

23 September 2018

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23 September 2018

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Increased resistance to CD4 CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes

21 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22461703

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Insulin-dependent diabetes mellitus

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22461703

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Functional defects and the influence of age on the frequency of CD4 CD25 T-cells in type 1 diabetes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22461703

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4049/JIMMUNOL.1100272

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703 AND SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703 AND SRC:MED&resulttype=core&format=json

27 January 2020

PubMed publication ID

22461703

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703 AND SRC:MED&resulttype=core&format=json