Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC. (Q36034016)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26346220 AND SRC:MED&resulttype=core&format=json

23 February 2020

title

Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC (English)

1 reference

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23 February 2020

1 reference

5

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23 February 2020

author name string

Qiang Chen

1

1 reference

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23 February 2020

Monica N Kinde

2

1 reference

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23 February 2020

Palaniappa Arjunan

3

1 reference

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23 February 2020

Marta M Wells

4

1 reference

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23 February 2020

Yan Xu

6

1 reference

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23 February 2020

Pei Tang

7

1 reference

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23 February 2020

language of work or name

English

0 references

publication date

8 September 2015

1 reference

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23 February 2020

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23 February 2020

volume

5

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23 February 2020

page(s)

13833

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Creative Commons Attribution 4.0 International

23 February 2020

copyright license

start time

8 September 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Conformational Changes Underlying Desensitization of the Pentameric Ligand-Gated Ion Channel ELIC.

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The prokaryote ligand-gated ion channel ELIC captured in a pore blocker-bound conformation by the Alzheimer's disease drug memantine

2 October 2017

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Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.

2 October 2017

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2 October 2017

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NMR structures of the human α7 nAChR transmembrane domain and associated anesthetic binding sites

2 October 2017

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Insights into Distinct Modulation of 7 and 7 2 Nicotinic Acetylcholine Receptors by the Volatile Anesthetic Isoflurane

2 October 2017

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2 October 2017

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Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel

2 October 2017

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Multisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)

2 October 2017

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Asymmetric ligand binding facilitates conformational transitions in pentameric ligand-gated ion channels

2 October 2017

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Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog

2 October 2017

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Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

2 October 2017

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NMR resolved multiple anesthetic binding sites in the TM domains of the α4β2 nAChR

2 October 2017

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Reversal of ion-charge selectivity renders the pentameric ligand-gated ion channel GLIC insensitive to anaesthetics

2 October 2017

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Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine

2 October 2017

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2 October 2017

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General anesthetics predicted to block the GLIC pore with micromolar affinity

2 October 2017

1 reference

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Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals

2 October 2017

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Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine

2 October 2017

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Isoflurane alters the structure and dynamics of GLIC.

2 October 2017

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Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC

2 October 2017

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X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

2 October 2017

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Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels

2 October 2017

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Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel

2 October 2017

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Anesthetic Binding in a Pentameric Ligand-Gated Ion Channel: GLIC

2 October 2017

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Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Photoaffinity labeling the propofol binding site in GLIC.

11 July 2018

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23 September 2018

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Identification of Nicotinic Acetylcholine Receptor Amino Acids Photolabeled by the Volatile Anesthetic Halothane

23 September 2018

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The in vitro and in vivo enantioselectivity of etomidate implicates the GABAA receptor in general anaesthesia.

23 September 2018

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23 September 2018

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23 September 2018

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The n-alcohol site in the nicotinic receptor pore is a hydrophobic patch

23 September 2018

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Cognitive dysfunction 1-2 years after non-cardiac surgery in the elderly. ISPOCD group. International Study of Post-Operative Cognitive Dysfunction

23 September 2018

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Effects of thiopental and its optical isomers on nicotinic acetylcholine receptors

23 September 2018

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Intravenous anesthetics differentially modulate ligand-gated ion channels

23 September 2018

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Human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes predict efficacy of halogenated compounds that disobey the Meyer-Overton rule

23 September 2018

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Differential sensitivities of mammalian neuronal and muscle nicotinic acetylcholine receptors to general anesthetics

23 September 2018

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Alpha 4 beta 2 neuronal nicotinic acetylcholine receptors in the central nervous system are inhibited by isoflurane and propofol, but alpha 7-type nicotinic acetylcholine receptors are unaffected

23 September 2018

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Volume changes on protein folding.

23 September 2018

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A discrete site for general anesthetics on a postsynaptic receptor.

23 September 2018

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23 September 2018

Identifiers

DOI

10.1038/SREP13833

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26346220 AND SRC:MED&resulttype=core&format=json

23 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26346220 AND SRC:MED&resulttype=core&format=json

23 February 2020

PubMed publication ID

26346220

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26346220 AND SRC:MED&resulttype=core&format=json