Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme (Q36016766)

11 August 2017

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title

Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme (English)

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11 August 2017

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Steffen Rossner

1

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11 August 2017

Christine Lange-Dohna

series ordinal

2

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11 August 2017

Ulrike Zeitschel

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3

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11 August 2017

J Regino Perez-Polo

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4

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11 August 2017

language of work or name

English

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publication date

1 January 2005

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Journal of Neurochemistry

11 August 2017

number of pages

9

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based on heuristic

inferred from page(s)

published in

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11 August 2017

volume

92

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11 August 2017

issue

2

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11 August 2017

page(s)

226-234

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TGF-beta(1), regulation of alzheimer amyloid precursor protein mRNA expression in a normal human astrocyte cell line: mRNA stabilization

11 August 2017

cites work

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Guinea-pig primary cell cultures provide a model to study expression and amyloidogenic processing of endogenous amyloid precursor protein

21 January 2018

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A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

21 January 2018

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Immunological aspects of microglia: relevance to Alzheimer's disease

21 January 2018

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Expression of beta-secretase mRNA in transgenic Tg2576 mouse brain with Alzheimer plaque pathology

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Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes

21 January 2018

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Oxygen free radicals in rat limbic structures after kainate-induced seizures.

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

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Maturation and pro-peptide cleavage of beta-secretase

21 January 2018

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Global ischemia activates nuclear factor-kappa B in forebrain neurons of rats

21 January 2018

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Sp1 and Smad transcription factors co-operate to mediate TGF-beta-dependent activation of amyloid-beta precursor protein gene transcription.

21 January 2018

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Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

21 January 2018

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Beta-secretase activity increases with aging in human, monkey, and mouse brain.

21 January 2018

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Regulation of beta-amyloid precursor protein isoform mRNAs by transforming growth factor-beta 1 and interleukin-1 beta in astrocytes

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Responses in the aged rat brain after total immunolesion

21 January 2018

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Model for aging in the basal forebrain cholinergic system

21 January 2018

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Repeated immunolesions display diminished stress response signal

21 January 2018

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Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

21 January 2018

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Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent

21 January 2018

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Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

21 January 2018

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Interferon gamma stimulates beta-secretase expression and sAPPbeta production in astrocytes

21 January 2018

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

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Copernicus revisited: amyloid beta in Alzheimer's disease

21 January 2018

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Microglia and Alzheimer's disease

21 January 2018

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

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Effect of NGF treatment on outcome measures in a rat model of middle cerebral artery occlusion

21 January 2018

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Animal models in the study of the biological function of genes on human chromosome 21 and their role in the pathophysiology of Down syndrome

21 January 2018

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Cloning and expression of the rat BACE1 promoter.

21 January 2018

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Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice

21 January 2018

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Pro-regenerative properties of cytokine-activated astrocytes.

21 January 2018

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Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

21 January 2018

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

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Altered expression of apolipoprotein E, amyloid precursor protein and presenilin-1 is associated with chronic reactive gliosis in rat cortical tissue.

21 January 2018

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Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.

21 January 2018

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21 January 2018

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Alzheimer's disease: a dysfunction of the amyloid precursor protein(1).

21 January 2018

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A new role for astrocytes: beta-amyloid homeostasis and degradation

21 January 2018

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BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

21 January 2018

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Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse

21 January 2018

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Differential effects of unaggregated and aggregated amyloid beta protein (1-40) on K( ) channel currents in primary cultures of rat cerebellar granule and cortical neurones

21 January 2018

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Alteration of Transcription Factor Binding Activities in the Ischemic Rat-Brain

21 January 2018

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The production of an amyloidogenic metabolite of the Alzheimer amyloid beta precursor protein (APP) in thyroid cells is stimulated by interleukin 1 beta, but inhibited by interferon gamma.

21 January 2018

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

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Induction of apoptosis in the CNS during development by the combination of hyperoxia and inhibition of glutathione synthesis

21 January 2018

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Alterations of Antioxidant Enzymes and Oxidative Damage to Macromolecules in Different Organs of Rats During Aging

21 January 2018

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NF-kappaB activity decreases in basal forebrain of young and aged rats after hyperoxia

21 January 2018

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Attenuated transcriptional responses to oxidative stress in the aged rat brain

21 January 2018

1 reference

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New evidence that the Alzheimer beta-amyloid peptide does not spontaneously form free radicals: an ESR study using a series of spin-traps.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2004.02857.X

Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2004.02857.X

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2004.02857.X

Microglia cells are the driving force in fibrillar plaque formation, whereas astrocytes are a leading factor in plague degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2004.02857.X

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2004.02857.X

Responses of young and aged rat CNS to partial cholinergic immunolesions and NGF treatment

21 January 2018

1 reference

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Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2004.02857.X

Adult mouse astrocytes degrade amyloid-beta in vitro and in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2004.02857.X

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2004.02857.X

Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2004.02857.X

10.1111/J.1471-4159.2004.02857.X

21 January 2018

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release_hemaqxwctfbibaz6xigagvikhi

11 August 2017

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