DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy (Q36012002)

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English	DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy	scientific article

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30 December 2019

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Europe PubMed Central

DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy (English)

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Europe PubMed Central

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30 December 2019

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30 December 2019

author name string

Julie L Tubbs

1

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30 December 2019

Anthony E Pegg

2

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30 December 2019

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7 May 2007

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30 December 2019

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30 December 2019

6

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30 December 2019

1100-1115

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30 December 2019

Human variants of O6-alkylguanine-DNA alkyltransferase

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2 October 2017

The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair.

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Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair.

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2 October 2017

DNA damage-induced cell death by apoptosis.

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2 October 2017

Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage

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2 October 2017

ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts

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2 October 2017

Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors

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2 October 2017

A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma

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2 October 2017

Targeted modulation of MGMT: clinical implications

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2 October 2017

O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts

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2 October 2017

Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma

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2 October 2017

The P140K mutant of human O(6)-methylguanine-DNA-methyltransferase (MGMT) confers resistance in vitro and in vivo to temozolomide in combination with the novel MGMT inactivator O(6)-(4-bromothenyl)guanine

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2 October 2017

Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase

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2 October 2017

DNA base damage recognition and removal: new twists and grooves

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2 October 2017

MGMT gene silencing and benefit from temozolomide in glioblastoma

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2 October 2017

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

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2 October 2017

A bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O6-alkylguanine-DNA alkyltransferase and endonuclease V activities

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2 October 2017

Enhanced in vivo selection of bone marrow cells by retroviral-mediated coexpression of mutant O6-methylguanine-DNA-methyltransferase and HOXB4.

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2 October 2017

Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations

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2 October 2017

Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility

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2 October 2017

Lentivirus-mediated expression of mutant MGMTP140K protects human CD34 cells against the combined toxicity of O6-benzylguanine and 1,3-bis(2-chloroethyl)-nitrosourea or temozolomide

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2 October 2017

Structure and function of the double-strand break repair machinery.

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2 October 2017

2-amino-O4-benzylpteridine derivatives: potent inactivators of O6-alkylguanine-DNA alkyltransferase

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2 October 2017

Folate-targeted chemotherapy

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2 October 2017

MGMT: its role in cancer aetiology and cancer therapeutics

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2 October 2017

A randomized phase I and pharmacological trial of sequences of 1,3-bis(2-chloroethyl)-1-nitrosourea and temozolomide in patients with advanced solid neoplasms

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2 October 2017

Protection and selection for gene therapy in the hematopoietic system

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2 October 2017

An Msh2 point mutation uncouples DNA mismatch repair and apoptosis

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2 October 2017

Hammerhead ribozyme-mediated sensitization of human tumor cells after treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea

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2 October 2017

Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer

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2 October 2017

In vivo selection of MGMT(P140K) lentivirus–transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning

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2 October 2017

Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis

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2 October 2017

Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway

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2 October 2017

DNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase. Effects of protein and DNA alkylation on complex stability

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2 October 2017

Degradation of the alkylated form of the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase

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2 October 2017

Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma

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2 October 2017

O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy

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2 October 2017

Monosaccharide-linked inhibitors of O(6)-methylguanine-DNA methyltransferase (MGMT): synthesis, molecular modeling, and structure-activity relationships

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2 October 2017

The modified human DNA repair enzyme O(6)-methylguanine-DNA methyltransferase is a negative regulator of estrogen receptor-mediated transcription upon alkylation DNA damage

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2 October 2017

Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide

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2 October 2017

Inactivation of O6-alkylguanine-DNA alkyltransferase by 8-substituted O6-benzylguanine analogs in mice

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2 October 2017

Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine

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2 October 2017

DNA-binding mechanism of the Escherichia coli Ada O(6)-alkylguanine-DNA alkyltransferase

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2 October 2017

Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase

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2 October 2017

Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding

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2 October 2017

Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA

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2 October 2017

DNA bending and a flip-out mechanism for base excision by the helix–hairpin–helix DNA glycosylase, Escherichia coli AlkA

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2 October 2017

DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]

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2 October 2017

Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase

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2 October 2017

Hyperthermostable protein structure maintained by intra and inter-helix ion-pairs in archaeal O6-methylguanine-DNA methyltransferase

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2 October 2017

Role of codon 160 in the sensitivity of human O6-alkylguanine-DNA alkyltransferase to O6-benzylguanine.

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2 October 2017

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.

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2 October 2017

Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis

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2 October 2017

Reaction and binding of oligodeoxynucleotides containing analogues of O6-methylguanine with wild-type and mutant human O6-alkylguanine-DNA alkyltransferase

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2 October 2017

Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chain

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2 October 2017

Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision

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2 October 2017

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23 September 2018

Investigation of the role of tyrosine-114 in the activity of human O6-alkylguanine-DNA alkyltranferase

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2 October 2017

Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.

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2 October 2017

Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions

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2 October 2017

Implication of Localization of Human DNA Repair Enzyme O6-Methylguanine-DNA Methyltransferase at Active Transcription Sites in Transcription-Repair Coupling of the Mutagenic O6-Methylguanine Lesion

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2 October 2017

Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials

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2 October 2017

A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA

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2 October 2017

Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea

1 reference

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2 October 2017

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1 reference

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2 October 2017

Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine

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2 October 2017

Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli

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2 October 2017

Structure, Function, and Inhibition of O6-Alkylguanine-DNA Alkyltransferase

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2 October 2017

Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction

1 reference

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2 October 2017

DNA crosslinking and cytotoxicity in normal and transformed human cells treated with antitumor nitrosoureas

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2 October 2017

Isolation and purification of O6-alkylguanine-DNA alkyltransferase from human leukemic cells. Prevention of chloroethylnitrosourea-induced cross-links by purified enzyme

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2 October 2017

Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents

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2 October 2017

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents

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2 October 2017

Why do cancer cells have such a high glycolytic rate?

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2 October 2017

Relative efficiencies of the bacterial, yeast, and human DNA methyltransferases for the repair of O6-methylguanine and O4-methylthymine. Suggestive evidence for O4-methylthymine repair by eukaryotic methyltransferases

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2 October 2017

Phase I study of streptozocin- and carmustine-sequenced administration in patients with advanced cancer

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2 October 2017

Dual agent chemoprotection by retroviral co-expression of either MDR1 or MRP1 with the P140K mutant of O6-methylguanine-DNA-methyl transferase

1 reference

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11 July 2018

Novel synthesis of O6-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

11 July 2018

Hematopoietic stem cell gene therapy of murine protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

11 July 2018

Debenzylation of O(6)-benzyl-8-oxoguanine in human liver: implications for O(6)-benzylguanine metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

11 July 2018

Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

11 July 2018

Ribozyme-mediated modulation of human O6-methylguanine-DNA methyltransferase expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

11 July 2018

Differences in DNA alkylation products formed in sensitive and resistant human glioma cells treated with N-(2-chloroethyl)-N-nitrosourea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

11 July 2018

Specific amino acid sequences required for O6-methylguanine-DNA methyltransferase activity: analyses of three residues at or near the methyl acceptor site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

11 July 2018

Site directed mutagenesis of two cysteine residues in the E. coli ogt O6-alkylguanine DNA alkyltransferase protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

11 July 2018

Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

11 July 2018

Structural studies of MJ1529, an O6-methylguanine-DNA methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Mismatch repair-dependent iterative excision at irreparable O6-methylguanine lesions in human nuclear extracts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34 peripheral blood cells with O6-methylguanine DNA methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Function of domains of human O6-alkylguanine-DNA alkyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Phase I study of O6-benzylguanine and temozolomide administered daily for 5 days to pediatric patients with solid tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Molecular modeling of O6-methylguanine-DNA methyltransferase mutant proteins encoded by single nucleotide polymorphisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

The structure of the human AGT protein bound to DNA and its implications for damage detection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Beta-glucuronidase-cleavable prodrugs of O6-benzylguanine and O6-benzyl-2'-deoxyguanosine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Reversing DNA damage with a directional bias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Inhibition of O6-methylguanine-DNA methyltransferase by glucose-conjugated inhibitors: comparison with nonconjugated inhibitors and effect on fotemustine and temozolomide-induced cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

DNA binding and nucleotide flipping by the human DNA repair protein AGT.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Folate receptor-targeted drugs for cancer and inflammatory diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Active-site alkylation destabilizes human O6-alkylguanine DNA alkyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

How Do DNA Repair Proteins Locate Potential Base Lesions? A Chemical Crosslinking Method to Investigate O6-Alkylguanine-DNA Alkyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Pharmacokinetics of O6-benzylguanine (NSC637037) and its metabolite, 8-oxo-O6-benzylguanine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

O6-benzylguanine-mediated enhancement of chemotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Determination of the optimal modulatory dose of O6-benzylguanine in patients with surgically resectable tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Effect of O6-(4-bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Repair of oligodeoxyribonucleotides by O(6)-alkylguanine-DNA alkyltransferase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Interaction of mammalian O(6)-alkylguanine-DNA alkyltransferases with O(6)-benzylguanine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Mechanisms of tolerance to DNA damaging therapeutic drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Novel DNA repair alkyltransferase from Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Inactivation of O(6)-methylguanine-DNA methyltransferase by glucose-conjugated inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Relationship between O6-methylguanine-DNA methyltransferase levels and clinical response induced by chloroethylnitrosourea therapy in glioma patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Synthesis of DNA oligonucleotides containing site-specifically incorporated O6-[4-oxo-4-(3-pyridyl)butyl]guanine and their reaction with O6-alkylguanine-DNA alkyltransferase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Expression of the inactive C145A mutant human O6-alkylguanine-DNA alkyltransferase in E.coli increases cell killing and mutations by N-methyl-N'-nitro-N-nitrosoguanidine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

O6-benzylguanine and its role in chemotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Involvement of the mismatch repair system in temozolomide-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

The Chloroethylnitrosoureas: Sensitivity and Resistance to Cancer Chemotherapy at the Molecular Level

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Mammalian DNA repair methyltransferases shield O4MeT from nucleotide excision repair.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Amino acid residues affecting the activity and stability of human O6-alkylguanine-DNA alkyltransferase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

A single amino acid change in human O6-alkylguanine-DNA alkyltransferase decreasing sensitivity to inactivation by O6-benzylguanine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Requirement of the Pro-Cys-His-Arg sequence for O6-methylguanine-DNA methyltransferase activity revealed by saturation mutagenesis with negative and positive screening.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Differential inactivation of O6-methylguanine-DNA methyltransferase activity by O6-arylmethylguanines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

Over-expression of facilitative glucose transporter genes in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1993358

23 September 2018

O6-benzylguanine in humans: metabolic, pharmacokinetic, and pharmacodynamic findings

1 reference

https://pubmed.ncbi.nlm.nih.gov/17485252

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17485252

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repair of O6-benzylguanine by the Escherichia coli Ada and Ogt and the human O6-alkylguanine-DNA alkyltransferases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17485252

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17485252

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural analysis of flexible proteins in solution by small angle X-ray scattering combined with crystallography

1 reference

https://pubmed.ncbi.nlm.nih.gov/17485252

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine

1 reference

https://pubmed.ncbi.nlm.nih.gov/17485252

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of two conserved amino acids, glutamine 90 and asparagine 137, in O6-methylguanine-DNA methyltransferase stability, activity and substrate specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17485252

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA adducts and the mechanism of carcinogenesis and cytotoxicity of methylating agents of environmental and clinical significance

1 reference

https://pubmed.ncbi.nlm.nih.gov/17485252

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/17485252

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-directed mutagenesis of glutamic acid 172 to glutamine completely inactivated human O6-alkylguanine-DNA-alkyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17485252

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement effect of O6-fluorobenzylguanines on chloroethylnitrosourea cytotoxicity in tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17485252

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O6-alkylguanine DNA lesions trigger apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17485252

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of DNA repair as a means of increasing the antitumor activity of DNA reactive agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/17485252

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct demonstration in synthetic oligonucleotides that N,N'-bis(2-chloroethyl)-nitrosourea cross links N1 of deoxyguanosine to N3 of deoxycytidine on opposite strands of duplex DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/17485252

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.DNAREP.2007.03.011

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17485252 AND SRC:MED&resulttype=core&format=json

30 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17485252 AND SRC:MED&resulttype=core&format=json

30 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17485252 AND SRC:MED&resulttype=core&format=json

30 December 2019

ResearchGate publication ID

0 references

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