Endogenous, or therapeutically induced, type I interferon responses differentially modulate Th1/Th17-mediated autoimmunity in the CNS. (Q36001691)

11 August 2017

10 references

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Endogenous, or therapeutically induced, type I interferon responses differentially modulate Th1/Th17-mediated autoimmunity in the CNS. (English)

1 reference

CNS demyelinating autoimmune diseases

11 August 2017

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25 April 2019

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25 June 2019

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9 August 2019

12 October 2019

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3 December 2020

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3 August 2019

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12 October 2019

hemic and immune systems

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18 October 2019

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20 November 2019

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3 December 2020

Ulrich Kalinke

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Marco Prinz

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Marco Prinz

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11 August 2017

language of work or name

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20 March 2012

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Immunology & Cell Biology

11 August 2017

1 May 2012

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25 April 2019

30 June 2019

25 June 2019

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11 August 2017

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90

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505-509

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

11 August 2017

10 references

25 April 2019

30 June 2019

25 June 2019

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on focus list of Wikimedia project

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ScienceSource

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cites work

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2 October 2017

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Interferon-β exacerbates Th17-mediated inflammatory disease

2 October 2017

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RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.

2 October 2017

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IFN-α mediates the development of autoimmunity both by direct tissue toxicity and through immune cell recruitment mechanisms.

2 October 2017

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On the Role of Aggregates in the Immunogenicity of Recombinant Human Interferon Beta in Patients with Multiple Sclerosis

2 October 2017

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T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis

2 October 2017

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2 October 2017

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Redefining the role of interferon in the treatment of malignant diseases

2 October 2017

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2 October 2017

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Dendritic cells require a systemic type I interferon response to mature and induce CD4 Th1 immunity with poly IC as adjuvant

2 October 2017

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IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition.

2 October 2017

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The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

2 October 2017

1 reference

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Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells.

2 October 2017

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Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis.

2 October 2017

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Using measurements of neutralizing antibodies: the challenge of IFN-beta therapy

2 October 2017

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Interferons in multiple sclerosis: ten years' experience

2 October 2017

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Differentiation and function of Th17 T cells

2 October 2017

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Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors

2 October 2017

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Microarray analysis identifies a set of CXCR3 and CCR2 ligand chemokines as early IFNbeta-responsive genes in peripheral blood lymphocytes in vitro: an implication for IFNbeta-related adverse effects in multiple sclerosis

2 October 2017

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CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs

2 October 2017

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Psychiatric side effects of interferon-beta in multiple sclerosis

2 October 2017

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Interleukin 17-producing CD4 effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

2 October 2017

1 reference

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Escalating immunotherapy of multiple sclerosis--new aspects and practical application.

2 October 2017

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Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection.

2 October 2017

1 reference

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Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

2 October 2017

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T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire

2 October 2017

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Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

2 October 2017

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Interferon beta induces interleukin-10 expression: relevance to multiple sclerosis

2 October 2017

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Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS.

11 July 2018

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Epstein-Barr virus and multiple sclerosis: interaction with HLA.

23 September 2018

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IFN-beta inhibits human Th17 cell differentiation

23 September 2018

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23 September 2018

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CCR2 Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

23 September 2018

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T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-beta.

23 September 2018

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Type I IFN receptor signals directly stimulate local B cells early following influenza virus infection

23 September 2018

1 reference

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IL-10 promoter haplotype influence on interferon treatment response in multiple sclerosis.

23 September 2018

1 reference

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IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis.

23 September 2018

1 reference

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Complex immunomodulatory effects of interferon-beta in multiple sclerosis include the upregulation of T helper 1-associated marker genes.

23 September 2018

1 reference

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Suppression of relapsing experimental autoimmune encephalomyelitis in the SJL/J mouse by oral administration of type I interferons

23 September 2018

1 reference

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Type I IFNs enhance the terminal differentiation of dendritic cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365287

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

21 October 2018

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TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

21 January 2018

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Crossref

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Defining the response to interferon-β in relapsing-remitting multiple sclerosis patients

21 January 2018

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Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation

21 January 2018

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12 December 2020

Pharmacogenomics of responsiveness to interferon IFN-beta treatment in multiple sclerosis: a genetic screen of 100 type I interferon-inducible genes

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12 December 2020

Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia

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12 December 2020

Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells

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12 December 2020

LOX-1 as a natural IFN- -mediated signal for apoptotic cell uptake and antigen presentation in dendritic cells

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12 December 2020

Interferon beta induces T-helper 2 immune deviation in MS

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12 December 2020

IL-27 mediates the response to IFN-β therapy in multiple sclerosis patients by inhibiting Th17 cells

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12 December 2020

Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonβ therapy in multiple sclerosis

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12 December 2020

Interferon-gamma-secreting cells in multiple sclerosis patients treated with interferon beta-1b

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12 December 2020

Oral administration of IFN-alpha is superior to subcutaneous administration of IFN-alpha in the suppression of chronic relapsing experimental autoimmune encephalomyelitis

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12 December 2020

Identifiers

DOI

10.1038/ICB.2012.8

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

22430251

1 reference