Synaptic NMDA receptors mediate hypoxic excitotoxic death (Q35993627)

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1 February 2020

title

Synaptic NMDA receptors mediate hypoxic excitotoxic death (English)

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4

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1 February 2020

author name string

Christine M Wroge

series ordinal

1

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1 February 2020

Joshua Hogins

series ordinal

2

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1 February 2020

Larry Eisenman

series ordinal

3

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1 February 2020

language of work or name

English

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publication date

1 May 2012

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1 February 2020

published in

Journal of Neuroscience

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volume

32

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issue

19

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1 February 2020

page(s)

6732-6742

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Tonic NMDA receptor-mediated current in prefrontal cortical pyramidal cells and fast-spiking interneurons

1 February 2020

cites work

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Synaptic and Extrasynaptic NMDA Receptors Differentially Modulate Neuronal Cyclooxygenase-2 Function, Lipid Peroxidation, and Neuroprotection

2 October 2017

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Presynaptic silencing is an endogenous neuroprotectant during excitotoxic insults

2 October 2017

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Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and function

2 October 2017

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A signaling cascade of nuclear calcium-CREB-ATF3 activated by synaptic NMDA receptors defines a gene repression module that protects against extrasynaptic NMDA receptor-induced neuronal cell death and ischemic brain damage.

2 October 2017

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Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

2 October 2017

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Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses

2 October 2017

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Synaptic activity and nuclear calcium signaling protect hippocampal neurons from death signal-associated nuclear translocation of FoxO3a induced by extrasynaptic N-methyl-D-aspartate receptors

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Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

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Memantine binding to a superficial site on NMDA receptors contributes to partial trapping

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Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke

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Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

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2 October 2017

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2 October 2017

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Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

2 October 2017

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2 October 2017

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2 October 2017

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27 July 2018

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Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production.

27 July 2018

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23 September 2018

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Reverse glial glutamate uptake triggers neuronal cell death through extrasynaptic NMDA receptor activation

23 September 2018

1 reference

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Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.

23 September 2018

1 reference

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Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices.

23 September 2018

1 reference

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NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo

23 September 2018

1 reference

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Actin-dependent activation of presynaptic silent synapses contributes to long-term synaptic plasticity in developing hippocampal neurons.

23 September 2018

1 reference

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Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons

23 September 2018

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Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters

23 September 2018

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23 September 2018

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Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated

23 September 2018

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Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity

23 September 2018

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Glutamate release in severe brain ischaemia is mainly by reversed uptake

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Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain

23 September 2018

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Extrasynaptic Glutamate Diffusion in the Hippocampus: Ultrastructural Constraints, Uptake, and Receptor Activation

23 September 2018

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Interactions between the glycine and glutamate binding sites of the NMDA receptor.

23 September 2018

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The developmental onset of NMDA receptor-channel activity during neuronal migration

23 September 2018

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23 September 2018

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Primary culture of identified neurons from the visual cortex of postnatal rats.

23 September 2018

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Distinct roles of synaptic and extrasynaptic NMDA receptors in excitotoxicity

23 September 2018

1 reference

12 December 2020

Synaptic activity mediates death of hypoxic neurons

1 reference

12 December 2020

Presynaptic influence on the time course of fast excitatory synaptic currents in cultured hippocampal cells

1 reference

12 December 2020

Components of glial responses to exogenous and synaptic glutamate in rat hippocampal microcultures

1 reference

12 December 2020

Trapping channel block of NMDA-activated responses by amantadine and memantine

1 reference

12 December 2020

Passive and synaptic properties of hippocampal neurons grown in microcultures and in mass cultures

1 reference

12 December 2020

Lesions of excitatory pathways reduce hippocampal cell death after transient forebrain ischemia in the gerbil

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12 December 2020

NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro

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12 December 2020

10.1523/JNEUROSCI.6371-11.2012

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573696 AND SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573696 AND SRC:MED&resulttype=core&format=json

1 February 2020

PubMed publication ID

22573696

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573696 AND SRC:MED&resulttype=core&format=json