The pharmacology of chlormethiazole: a potential neuroprotective agent? (Q35981029)

PubMed publication ID

11 August 2017

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title

The pharmacology of chlormethiazole: a potential neuroprotective agent? (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741715&resulttype=core&format=json

12 May 2020

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M J Wilby

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741715&resulttype=core&format=json

12 May 2020

P J Hutchinson

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741715&resulttype=core&format=json

12 May 2020

publication date

1 January 2004

1 reference

PubMed publication ID

15592579

CNS Neuroscience & Therapeutics

11 August 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741715&resulttype=core&format=json

12 May 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741715&resulttype=core&format=json

12 May 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741715&resulttype=core&format=json

12 May 2020

page(s)

281-294

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741715&resulttype=core&format=json

Pharmacokinetics and sedative effects in healthy subjects and subjects with impaired liver function after continuous infusion of clomethiazole

12 May 2020

cites work

1 reference

https://api.crossref.org/works/10.1111/J.1527-3458.2004.TB00028.X

The protective action of chlormethiazole against ischaemia‐induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1527-3458.2004.TB00028.X

Neuroprotective activity of chlormethiazole following transient forebrain ischaemia in the gerbil

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1527-3458.2004.TB00028.X

The effects of chlormethiazole on single unit activity in rat brain; interactions with inhibitory and excitatory neurotransmitters

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1527-3458.2004.TB00028.X

The Clomethiazole Acute Stroke Study in tissue-type plasminogen activator-treated stroke (CLASS-T): final results

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1527-3458.2004.TB00028.X

Direct measurement of chlormethiazole extraction by liver, lung and kidney in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1527-3458.2004.TB00028.X

Double-blind controlled trial of gamma-hydroxybutyrate and clomethiazole in the treatment of alcohol withdrawal

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1527-3458.2004.TB00028.X

The effect of chlormethiazole on neuronal damage in a model of transient focal ischaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1527-3458.2004.TB00028.X

Clomethiazole acute stroke study (CLASS): results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1527-3458.2004.TB00028.X

Deaths in connection with chlormethiazole (heminevrin) therapy

21 January 2018

1 reference

12 December 2020

Functional benefit from clomethiazole treatment after focal cerebral ischemia in a nonhuman primate species.

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of clomethiazole after oral and rectal administration in healthy subjects

1 reference

12 December 2020

Clomethiazole (ZENDRA, CMZ) improves hind limb motor function and reduces neuronal damage after severe spinal cord injury in rat.

1 reference

12 December 2020

Results in 95 hemorrhagic stroke patients included in CLASS, a controlled trial of clomethiazole versus placebo in acute stroke patients

1 reference

12 December 2020

The metabolism of clomethiazole in gerbils and the neuroprotective and sedative activity of the metabolites

1 reference

12 December 2020

Clomethiazole protects against hemineglect in a primate model of stroke

1 reference

12 December 2020

Clomethiazole is neuroprotective in models of global and focal cerebral ischemia when infused at doses producing clinically relevant plasma concentrations

1 reference

12 December 2020

Neuroprotective agent chlomethiazole attenuates c-fos, c-jun, and AP-1 activation through inhibition of p38 MAP kinase

1 reference

12 December 2020

Chlormethiazole inhibits epileptiform activity by potentiating GABA(A) receptor function

1 reference

12 December 2020

Chlormethiazole in treatment of status epilepticus

1 reference

12 December 2020

Treatment of alcohol withdrawal: tiapride and carbamazepine versus clomethiazole. A pilot study

1 reference

12 December 2020

Clomethiazole Acute Stroke Study in ischemic stroke (CLASS-I): final results

1 reference

12 December 2020

Investigation of the effect of chlormethiazole on cerebral chemistry in neurosurgical patients: a combined study of microdialysis and a neuroprotective agent

1 reference

12 December 2020

Clinical trial of the neuroprotectant clomethiazole in coronary artery bypass graft surgery: a randomized controlled trial

1 reference

12 December 2020

Comparison of the neuroprotective effect of clomethiazole, AR-R15896AR and NXY-059 in a primate model of stroke using histological and behavioural measures

1 reference

12 December 2020

The effect of clomethiazole on plasma concentrations of interleukin-6, -8, -1beta, tumor necrosis factor-alpha, and neutrophil adhesion molecule expression during experimental extracorporeal circulation

1 reference

12 December 2020

Population pharmacokinetics of clomethiazole and its effect on the natural course of sedation in acute stroke patients

1 reference

12 December 2020

Long-term effects of clomethiazole in a model of global ischemia

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12 December 2020

Modulation of GABAA and glycine receptors by chlormethiazole

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12 December 2020

FUNCTIONAL EVALUATION: THE BARTHEL INDEX

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12 December 2020

Chlormethiazole: neurochemical actions at the gamma-aminobutyric acid receptor complex

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12 December 2020

Chlormethiazole sedation for critically ill patients in renal failure

1 reference

12 December 2020

Chlormethiazole--mode of action.

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12 December 2020

Indications of chlormethiazole as a protective agent in experimental endotoxemia

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12 December 2020

4,5-Dimethylthiazole-N-oxide-S-oxide: a metabolite of chlormethiazole in man.

1 reference

12 December 2020

Comparison of the efficacy of chlormethiazole and diazepam as i.v. sedatives for supplementation of extradural anaesthesia

1 reference

12 December 2020

Chlormethiazole: an effective oral sedative for cranial CT scans in children

1 reference

12 December 2020

A double-blind comparison of chlormethiazole and dichloralphenazone:a sedative/hypnotic in geriatric medicine

1 reference

12 December 2020

Failure of IV atropine to abolish nasal irritation caused by chlormethiazole infusion in elderly patients undergoing spinal anaesthesia.

1 reference

12 December 2020

An integrated study of pharmacokinetics and pharmacodynamics of chlormethiazole in healthy young volunteers.

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12 December 2020

Cimetidine impairs the elimination of chlormethiazole

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12 December 2020

Prolonged infusion of chlormethiazole in intensive care

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12 December 2020

Delayed postischemic hypothermia: a six month survival study using behavioral and histological assessments of neuroprotection.

1 reference

12 December 2020

Attenuation by chlormethiazole of oedema following focal ischaemia in the cerebral cortex of the rat.

1 reference

12 December 2020

The effects of chlormethiazole and nimodipine on cortical infarct area after focal cerebral ischaemia in the rat.

1 reference

12 December 2020

Clomethiazole protects the brain in transient forebrain ischemia when used up to 4 h after the insult

1 reference

12 December 2020

The neuroprotective effect of chlormethiazole on ischaemic neuronal damage following permanent middle cerebral artery ischaemia in the rat

1 reference

12 December 2020

The effect of oedema and tissue swelling on the measurement of neuroprotection; a study using chlormethiazole and permanent middle cerebral artery occlusion in rats

1 reference

12 December 2020

Effects of clomethiazole on radial-arm maze performance following global forebrain ischemia in gerbils

1 reference

12 December 2020

Is chlormethiazole neuroprotective in experimental global cerebral ischemia? A microdialysis and behavioral study

1 reference

12 December 2020

Treating alcohol dependence. Chlormethiazole is widely used in Europe

1 reference

12 December 2020

Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers

1 reference

12 December 2020

10.1111/J.1527-3458.2004.TB00028.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741715&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741715&resulttype=core&format=json

12 May 2020

PubMed publication ID

15592579

1 reference