Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice. (Q35939665)

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English	Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice.	scientific article

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22 February 2020

Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice (English)

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22 February 2020

neuropathic pain

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22 February 2020

Francesco Napolitano

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22 February 2020

Danilo De Gregorio

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22 February 2020

Fabiana Piscitelli

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22 February 2020

Roberta Lattanzi

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22 February 2020

Alessandro Usiello

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22 February 2020

Vincenzo Di Marzo

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22 February 2020

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F Guida

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F Marmo

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22 February 2020

R Romano

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22 February 2020

M Iannotta

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22 February 2020

C Belardo

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22 February 2020

I Marabese

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22 February 2020

A D'Aniello

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22 February 2020

F Rossi

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22 February 2020

A de Bartolomeis

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22 February 2020

V de Novellis

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22 February 2020

S Maione

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22 February 2020

publication date

12 August 2015

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22 February 2020

Molecular Brain

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22 February 2020

8

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22 February 2020

47

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22 February 2020

Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype

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2 October 2017

Emotional consequences of neuropathic pain: insight from preclinical studies

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The glutamatergic aspects of schizophrenia molecular pathophysiology: role of the postsynaptic density, and implications for treatment

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Endocannabinoids and neuropathic pain: focus on neuron-glia and endocannabinoid-neurotrophin interactions

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2 October 2017

Neuroinflammation and comorbidity of pain and depression

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2 October 2017

Glia and mast cells as targets for palmitoylethanolamide, an anti-inflammatory and neuroprotective lipid mediator

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Cellular, molecular, and epigenetic mechanisms in non-associative conditioning: implications for pain and memory

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Peripheral nerve injury is accompanied by chronic transcriptome-wide changes in the mouse prefrontal cortex

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2 October 2017

Palmitoylethanolamide is a disease-modifying agent in peripheral neuropathy: pain relief and neuroprotection share a PPAR-alpha-mediated mechanism.

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Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy

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Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system

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Pretreatment with intrathecal amitriptyline potentiates anti-hyperalgesic effects of post-injury intra-peritoneal amitriptyline following spinal nerve ligation

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Common brain activations for painful and non-painful aversive stimuli

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2 October 2017

TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception

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Transient receptor potential vanilloid type 1 and pain development

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The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

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2 October 2017

The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats

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2 October 2017

Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats

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2 October 2017

mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists

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2 October 2017

The endocannabinoid system and pain

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2 October 2017

Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain

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Activation of extracellular signal-regulated kinase in the anterior cingulate cortex contributes to the induction of long-term potentiation in rats

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2 October 2017

Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain

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2 October 2017

Forebrain pain mechanisms

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An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder.

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2 October 2017

The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors

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Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouse.

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2 October 2017

D-cycloserine reduces neuropathic pain behavior through limbic NMDA-mediated circuitry

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Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals.

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2 October 2017

The search for the palmitoylethanolamide receptor.

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Chronic back pain is associated with decreased prefrontal and thalamic gray matter density.

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Genetic enhancement of inflammatory pain by forebrain NR2B overexpression

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Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception

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Spared nerve injury: an animal model of persistent peripheral neuropathic pain

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Wind-up of spinal cord neurones and pain sensation: much ado about something?

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Selective association of N-methyl aspartate and quisqualate types of L-glutamate receptor with brain postsynaptic densities

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Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection

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Effects of intra-ventrolateral periaqueductal grey palmitoylethanolamide on thermoceptive threshold and rostral ventromedial medulla cell activity

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11 July 2018

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24 September 2018

D-aspartate modulates nociceptive-specific neuron activity and pain threshold in inflammatory and neuropathic pain condition in mice.

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PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice

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Dorsal striatum metabotropic glutamate receptor 8 affects nocifensive responses and rostral ventromedial medulla cell activity in neuropathic pain conditions.

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24 September 2018

Upregulation of presynaptic proteins and protein kinases associated with enhanced glutamate release from axonal terminals (synaptosomes) of the medial prefrontal cortex in rats with neuropathic pain

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24 September 2018

Antidepressants and mood stabilizers effects on histone deacetylase expression in C57BL/6 mice: Brain region specific changes

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24 September 2018

Palmitoylethanolamide reduces formalin-induced neuropathic-like behaviour through spinal glial/microglial phenotypical changes in mice

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24 September 2018

Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat.

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24 September 2018

Cell death mechanisms in the early stages of acute glutamate neurotoxicity.

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24 September 2018

Functional interaction between TRPV1 and mu-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia

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24 September 2018

D-aspartate prevents corticostriatal long-term depression and attenuates schizophrenia-like symptoms induced by amphetamine and MK-801.

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24 September 2018

Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats

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Cannabinoids Potentiate Emotional Learning Plasticity in Neurons of the Medial Prefrontal Cortex through Basolateral Amygdala Inputs.

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Inhibitory effect of anandamide on resiniferatoxin-induced sensory neuropeptide release in vivo and neuropathic hyperalgesia in the rat.

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Correlated discharges among putative pyramidal neurons and interneurons in the primate prefrontal cortex

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24 September 2018

Chronic dizocilpine or apomorphine and development of neuropathy in two animal models II: effects on brain cytokines and neurotrophins

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in response properties of nociceptive dorsal horn neurons in a murine model of cancer pain

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12 December 2020

based on heuristic

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Effects of antidepressants on gamma-aminobutyric acid- and N-methyl-D-aspartate-induced intracellular Ca(2 ) concentration increases in primary cultured rat cortical neurons

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12 December 2020

based on heuristic

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Identification and characterization of an N-methyl-D-aspartate-specific L-[3H]glutamate recognition site in synaptic plasma membranes

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S13041-015-0139-5

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26260027 AND SRC:MED&resulttype=core&format=json

22 February 2020

Dimensions Publication ID

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Europe PubMed Central

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22 February 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26260027 AND SRC:MED&resulttype=core&format=json

22 February 2020

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