Clinical strategies for expansion of haematopoietic stem cells (Q35934167)

11 August 2017

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title

Clinical strategies for expansion of haematopoietic stem cells (English)

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11 August 2017

Brian P Sorrentino

1

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11 August 2017

publication date

1 November 2004

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Nature Reviews Immunology

11 August 2017

published in

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11 August 2017

volume

4

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11 August 2017

issue

11

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11 August 2017

page(s)

878-888

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Stem cell transplantation for hemoglobinopathies

11 August 2017

cites work

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Complete reconstitution of human lymphocytes from cord blood CD34 cells using the NOD/SCID/γcnull mice model

21 January 2018

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Differential cytokine effects on primitive (CD34 CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin

21 January 2018

1 reference

Quantitative Analysis Reveals Expansion of Human Hematopoietic Repopulating Cells After Short-term Ex Vivo Culture

21 January 2018

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VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism

21 January 2018

1 reference

The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells

21 January 2018

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Osteoblastic cells regulate the haematopoietic stem cell niche

21 January 2018

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Identification of the haematopoietic stem cell niche and control of the niche size

21 January 2018

1 reference

Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche

21 January 2018

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Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

21 January 2018

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Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome

21 January 2018

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Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression

21 January 2018

1 reference

Cellular proliferation and transformation induced by HOXB4 and HOXB3 proteins involves cooperation with PBX1.

21 January 2018

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The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver

21 January 2018

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Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells

21 January 2018

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HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.

21 January 2018

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In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein

21 January 2018

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HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation

21 January 2018

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Prolonged production of NADPH oxidase-corrected granulocytes after gene therapy of chronic granulomatous disease

21 January 2018

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Retroviral transfer of the glucocerebrosidase gene into CD34 cells from patients with Gaucher disease: in vivo detection of transduced cells without myeloablation

21 January 2018

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In vivo selection of retrovirally transduced hematopoietic stem cells

21 January 2018

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Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells

21 January 2018

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Lentiviral transduction of P140K MGMT into human CD34( ) hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro

21 January 2018

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Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs

21 January 2018

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Reduction in hematopoietic stem cell numbers with in vivo drug selection can be partially abrogated by HOXB4 gene expression

21 January 2018

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Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector

21 January 2018

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Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia

21 January 2018

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Enforced adenoviral vector-mediated expression of HOXB4 in human umbilical cord blood CD34 cells promotes myeloid differentiation but not proliferation

21 January 2018

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High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34 cells, but impairs lymphomyeloid differentiation

21 January 2018

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Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.

21 January 2018

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Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo.

21 January 2018

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A role for Wnt signalling in self-renewal of haematopoietic stem cells

21 January 2018

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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

21 January 2018

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Wnt proteins are lipid-modified and can act as stem cell growth factors

21 January 2018

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Ex vivo targeting of p21Cip1/Waf1 permits relative expansion of human hematopoietic stem cells

21 January 2018

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Stem cell repopulation efficiency but not pool size is governed by p27(kip1).

21 January 2018

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Reduction in levels of the cyclin-dependent kinase inhibitor p27(kip-1) coupled with transforming growth factor beta neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cells

21 January 2018

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Molecular mechanism of transforming growth factor beta-mediated cell-cycle modulation in primary human CD34( ) progenitors

21 January 2018

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In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C.

21 January 2018

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Bmi1, stem cells, and senescence regulation

21 January 2018

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Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis

21 January 2018

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

21 January 2018

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Tumor suppression by Ink4a-Arf: progress and puzzles

21 January 2018

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

21 January 2018

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Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

21 January 2018

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

21 January 2018

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Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution

21 January 2018

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Megadose transplantation of purified peripheral blood CD34( ) progenitor cells from HLA-mismatched parental donors in children

21 January 2018

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Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection

21 January 2018

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Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

21 January 2018

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Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning

21 January 2018

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Restoration of lymphocyte function in Janus Kinase 3-deficient mice by retroviral-mediated gene transfer

21 January 2018

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A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

21 January 2018

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LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

21 January 2018

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Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia

21 January 2018

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In vivo selection using a cell-growth switch

21 January 2018

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Targeted expansion of genetically modified bone marrow cells

21 January 2018

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American Society of Gene Therapy (ASGT) ad hoc subcommittee on retroviral-mediated gene transfer to hematopoietic stem cells

21 January 2018

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Side effects of retroviral gene transfer into hematopoietic stem cells

21 January 2018

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Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

21 January 2018

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A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

21 January 2018

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Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell

21 January 2018

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Supralethal whole body irradiation and isologous marrow transplantation in man.

31 March 2020

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Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells

31 March 2020

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In vitro generation of long-term repopulating hematopoietic stem cells by fibroblast growth factor-1

31 March 2020

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Effects ofHOX homeobox genes in blood cell differentiation

31 March 2020

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Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo

31 March 2020

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The competitive nature of HOXB4-transduced HSC is limited by PBX1: the generation of ultra-competitive stem cells retaining full differentiation potential

31 March 2020

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Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein

31 March 2020

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Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.

31 March 2020

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CDK inhibitors: positive and negative regulators of G1-phase progression

31 March 2020

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Hematopoietic stem cell quiescence maintained by p21cip1/waf1

31 March 2020

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Clinical scale isolation of highly purified peripheral CD34 progenitors for autologous and allogeneic transplantation in children

31 March 2020

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Transplantation of highly purified peripheral-blood CD34 progenitor cells from related and unrelated donors in children with nonmalignant diseases

31 March 2020

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Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling

31 March 2020

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Hematopoietic stem-cell transplants using umbilical-cord blood

31 March 2020

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Transplantation of ex vivo expanded cord blood

31 March 2020

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Cord blood transplants: early recovery of neutrophils from co-transplanted sibling haploidentical progenitor cells and lack of engraftment of cultured cord blood cells, as ascertained by analysis of DNA polymorphisms

31 March 2020

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In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

31 March 2020

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Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI1487

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11 August 2017

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