Poxvirus-Based Active Immunotherapy with PD-1 and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice (Q35934137)

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English	Poxvirus-Based Active Immunotherapy with PD-1 and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

11 August 2017

Poxvirus-Based Active Immunotherapy with PD-1 and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice (English)

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Europe PubMed Central

PMC publication ID

11 August 2017

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Barbara Sennino

2

object named as

Barbara Sennino

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Europe PubMed Central

PMC publication ID

11 August 2017

author name string

Susan P Foy

1

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Europe PubMed Central

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11 August 2017

Tracy dela Cruz

3

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11 August 2017

Joseph J Cote

4

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11 August 2017

Evan J Gordon

5

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11 August 2017

Felicia Kemp

6

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Europe PubMed Central

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11 August 2017

Veronica Xavier

7

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11 August 2017

Alex Franzusoff

8

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11 August 2017

Ryan B Rountree

9

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11 August 2017

Stefanie J Mandl

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11 August 2017

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24 February 2016

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Europe PubMed Central

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11 August 2017

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Europe PubMed Central

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11 August 2017

11

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11 August 2017

2

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Europe PubMed Central

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11 August 2017

e0150084

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Europe PubMed Central

PMC publication ID

11 August 2017

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Creative Commons Attribution 4.0 International

24 February 2016

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4765931/fullTextXML

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PD-1/PD-L1 inhibitors.

1 reference

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2 October 2017

Immunotherapy in lung cancer

1 reference

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Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8 T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells

1 reference

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2 October 2017

PD-1 blockade induces responses by inhibiting adaptive immune resistance

1 reference

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Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

1 reference

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Immune impact induced by PROSTVAC (PSA-TRICOM), a therapeutic vaccine for prostate cancer

1 reference

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A combination trial of vaccine plus ipilimumab in metastatic castration-resistant prostate cancer patients: immune correlates.

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Clinical evaluation of TRICOM vector therapeutic cancer vaccines

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Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization

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Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape

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Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer

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2 October 2017

Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cells

1 reference

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2 October 2017

LAG-3 regulates plasmacytoid dendritic cell homeostasis

1 reference

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2 October 2017

PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer

1 reference

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2 October 2017

Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade

1 reference

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PD-1 and its ligands in tolerance and immunity

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LAG-3 regulates CD8 T cell accumulation and effector function in murine self- and tumor-tolerance systems

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Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

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Expression of lymphocyte activation gene 3 (LAG-3) on B cells is induced by T cells

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Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo

1 reference

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Delineation of an extended surface contact area on human CD4 involved in class II major histocompatibility complex binding

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Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand

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CD4 and CD8 recognition of class II and class I molecules of the major histocompatibility complex

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LAG-3, a novel lymphocyte activation gene closely related to CD4

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Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial

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12 December 2020

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Identifiers

10.1371/JOURNAL.PONE.0150084

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Europe PubMed Central

PMC publication ID

11 August 2017

2016PLoSO..1150084F

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

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