Structure and function of the epidermal growth factor (EGF/ErbB) family of receptors (Q35925840)

11 August 2017

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title

Structure and function of the epidermal growth factor (EGF/ErbB) family of receptors (English)

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11 August 2017

Daniel J Leahy

1

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11 August 2017

publication date

1 January 2004

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Advances in Protein Chemistry

11 August 2017

published in

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11 August 2017

volume

68

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11 August 2017

page(s)

1-27

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Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth

11 August 2017

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ErbB-targeted therapeutic approaches in human cancer

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The neu oncogene encodes an epidermal growth factor receptor-related protein

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Oncogenic kinase signalling

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HER2/neu: mechanisms of dimerization/oligomerization

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The extracellular domain of the epidermal growth factor receptor. Studies on the affinity and stoichiometry of binding, receptor dimerization and a binding-domain mutant

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7 January 2021

An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

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Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation

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7 January 2021

Receptors for epidermal growth factor and other polypeptide mitogens

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7 January 2021

ErbB-4: mechanism of action and biology

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7 January 2021

Epidermal Growth Factor

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7 January 2021

Epidermal growth factor stimulates phosphorylation in membrane preparations in vitro

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7 January 2021

Structure of the extracellular region of HER3 reveals an interdomain tether

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7 January 2021

Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

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7 January 2021

The deaf and the dumb: the biology of ErbB-2 and ErbB-3

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7 January 2021

Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets

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Nobel lecture. Epidermal growth factor

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7 January 2021

Epidermal growth factor

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7 January 2021

Specific radiolabeling of a cell surface receptor for epidermal growth factor

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7 January 2021

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

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7 January 2021

erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells

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7 January 2021

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7 January 2021

Identification of a determinant of epidermal growth factor receptor ligand-binding specificity using a truncated, high-affinity form of the ectodomain.

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7 January 2021

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization

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7 January 2021

Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

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7 January 2021

Transforming capacities of avian erythroblastosis virus mutants deleted in the erbA or erbB oncogenes

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7 January 2021

Oligomerization of epidermal growth factor receptors on A431 cells studied by time-resolved fluorescence imaging microscopy. A stereochemical model for tyrosine kinase receptor activation

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7 January 2021

The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors

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7 January 2021

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

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7 January 2021

Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Sequence plasticity in the antigen-binding site of a therapeutic anti-HER2 antibody

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7 January 2021

Interaction between proteins localized in membranes

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7 January 2021

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity

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7 January 2021

Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431

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7 January 2021

Dimerization of cell surface receptors in signal transduction

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7 January 2021

Isolation of the human placenta receptor for epidermal growth factor-urogastrone

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7 January 2021

The ErbB receptors and their role in cancer progression.

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7 January 2021

Deletion-mutant epidermal growth factor receptor in human gliomas: Effect of type II mutation on receptor function

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7 January 2021

Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma

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7 January 2021

Receptor signaling: when dimerization is not enough

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7 January 2021

Thermodynamic analysis of an antibody functional epitope

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7 January 2021

The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors

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7 January 2021

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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7 January 2021

Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules.

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7 January 2021

All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor

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7 January 2021

Requirement for neuregulin receptor erbB2 in neural and cardiac development

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7 January 2021

Two EGF molecules contribute additively to stabilization of the EGFR dimer

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7 January 2021

The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain

1 reference

https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

The ErbB signaling network: receptor heterodimerization in development and cancer

1 reference

https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Severe neuropathies in mice with targeted mutations in the ErbB3 receptor

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Single-molecule imaging of EGFR signalling on the surface of living cells

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Local aggregation of hormone–receptor complexes is required for activation by epidermal growth factor

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Cell signaling by receptor tyrosine kinases

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Signal transduction. Autoinhibition control

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Strain-dependent epithelial defects in mice lacking the EGF receptor

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Anti-sense transforming growth factor alpha oligonucleotides inhibit autocrine stimulated proliferation of a colon carcinoma cell line

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Evolutionary analysis of the ErbB receptor and ligand families

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cells

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Insulin and epidermal growth factor receptors contain the cysteine repeat motif found in the tumor necrosis factor receptor

1 reference

https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Identification of the EGF receptor on 3T3 cells by surface-specific iodination and gel electrophoresis

1 reference

https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

The erbB gene of avian erythroblastosis virus is a member of the src gene family

1 reference

https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

Untangling the ErbB signalling network

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https://api.crossref.org/works/10.1016/S0065-3233(04)68001-6

7 January 2021

10.1016/S0065-3233(04)68001-6

Identifiers

DOI

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11 August 2017

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