ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA. (Q35917073)

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7 March 2020

title

ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA (English)

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2

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author name string

Hui Zhang

1

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Waaqo Daddacha

3

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Seong-Hoon Park

4

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Xingzhe Li

5

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Yunfeng Pan

6

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Matthew Z Madden

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Duc M Duong

8

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Maohua Xie

9

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Bing Yu

10

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Matthew D Warren

11

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Elaine A Liu

12

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Vishal R Dhere

13

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Chunyang Li

14

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Ivan Pradilla

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Mylin A Torres

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Ya Wang

17

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William S Dynan

18

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Paul W Doetsch

19

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Xingming Deng

20

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Nicholas T Seyfried

21

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David Gius

22

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David S Yu

23

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publication date

4 February 2016

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7 March 2020

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volume

14

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issue

6

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page(s)

1435-1447

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SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing

7 March 2020

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SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway

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PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry

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SIRT2 directs the replication stress response through CDK9 deacetylation.

11 July 2018

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ATR phosphorylates SMARCAL1 to prevent replication fork collapse

11 July 2018

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A role for the MRN complex in ATR activation via TOPBP1 recruitment

11 July 2018

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The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation

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Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome

11 July 2018

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SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity

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ATR autophosphorylation as a molecular switch for checkpoint activation.

11 July 2018

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Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase

11 July 2018

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Franklin H. Epstein Lecture: Sirtuins, aging, and medicine

11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

11 July 2018

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Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

11 July 2018

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ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation

11 July 2018

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Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage

11 July 2018

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Replication protein A-mediated recruitment and activation of Rad17 complexes

11 July 2018

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

11 July 2018

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A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

11 July 2018

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The human Sir2 ortholog, SIRT2, is an NAD -dependent tubulin deacetylase

11 July 2018

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Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

11 July 2018

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An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication

11 July 2018

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ATR Regulates Fragile Site Stability

11 July 2018

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Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects

11 July 2018

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ATR and ATRIP: partners in checkpoint signaling

11 July 2018

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Structure of the major single-stranded DNA-binding domain of replication protein A suggests a dynamic mechanism for DNA binding

11 July 2018

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ATR disruption leads to chromosomal fragmentation and early embryonic lethality

11 July 2018

1 reference

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The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR.

11 July 2018

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10.1016/J.CELREP.2016.01.018

24 September 2018

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26854234 AND SRC:MED&resulttype=core&format=json

7 March 2020

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7 March 2020

PubMed publication ID

26854234

1 reference