Opposing roles of STAT1 and STAT3 in IL-21 function in CD4 T cells (Q35910035)

11 August 2017

Opposing roles of STAT1 and STAT3 in IL-21 function in CD4 T cells (English)

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11 August 2017

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5

Majid Kazemian

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11 August 2017

Chi-Keung Wan

1

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11 August 2017

Allison B Andraski

2

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11 August 2017

Rosanne Spolski

3

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11 August 2017

Peng Li

4

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11 August 2017

Jangsuk Oh

6

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11 August 2017

Leigh Samsel

7

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11 August 2017

Phillip A Swanson

8

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11 August 2017

Dorian B McGavern

9

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11 August 2017

Elizabeth P Sampaio

10

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11 August 2017

Alexandra F Freeman

11

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11 August 2017

Joshua D Milner

12

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11 August 2017

Steven M Holland

13

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11 August 2017

Warren J Leonard

14

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11 August 2017

language of work or name

English

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publication date

13 July 2015

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Proceedings of the National Academy of Sciences of the United States of America

11 August 2017

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11 August 2017

112

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11 August 2017

30

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11 August 2017

9394-9399

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describes a project that uses

11 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4522759/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

Hyper-IgE syndrome update

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8 T cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

IL-21 is the primary common γ chain-binding cytokine required for human B-cell differentiation in vivo

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection

11 July 2018

1 reference

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Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

Interleukin-21 effectively induces apoptosis in mantle cell lymphoma through a STAT1-dependent mechanism

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

A vital role for interleukin-21 in the control of a chronic viral infection

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

IL-21 is required to control chronic viral infection

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

A fundamental role for interleukin-21 in the generation of T follicular helper cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

Interleukin 21: a cytokine/cytokine receptor system that has come of age

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

11 July 2018

1 reference

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Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

11 July 2018

1 reference

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

The molecular basis of IL-21-mediated proliferation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

Cutting Edge: The direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

Synergy of IL-21 and IL-15 in regulating CD8 T cell expansion and function.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

A critical role for IL-21 in regulating immunoglobulin production

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

Mutational switch of an IL-6 response to an interferon-gamma-like response

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

SOCS proteins: negative regulators of cytokine signaling

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

The role of STATs in transcriptional control and their impact on cellular function

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

A novel transcription factor, T-bet, directs Th1 lineage commitment

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

IL-21 promotes CD8 CTL activity via the transcription factor T-bet

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

IL-21R on T cells is critical for sustained functionality and control of chronic viral infection

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

Identification of cellular intermediates and molecular pathways induced by IL-21 in human B cells

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

Alternative activation of STAT1 and STAT3 in response to interferon-gamma

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522759

24 September 2018

Identifiers

DOI

10.1073/PNAS.1511711112

1 reference

11 August 2017

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1 reference

11 August 2017

PubMed publication ID

26170288

1 reference