Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. (Q35901256)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609365 AND SRC:MED&resulttype=core&format=json

1 January 2020

title

Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation (English)

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1 January 2020

0 references

1

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1 January 2020

Morris J. Birnbaum

3

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1 January 2020

author name string

Jessica A Wofford

2

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1 January 2020

Jeffrey C Rathmell

4

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1 January 2020

Gary A Koretzky

5

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1 January 2020

language of work or name

English

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publication date

3 July 2007

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Proceedings of the National Academy of Sciences of the United States of America

1 January 2020

published in

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1 January 2020

volume

104

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1 January 2020

issue

29

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page(s)

12105-12110

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Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking

1 January 2020

cites work

1 reference

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Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions

27 July 2018

1 reference

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Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection

27 July 2018

1 reference

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Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924580

Akt-dependent transformation: there is more to growth than just surviving

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924580

Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism

27 July 2018

1 reference

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Requirement of c-myb in T cell development and in mature T cell function

27 July 2018

1 reference

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The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling

27 July 2018

1 reference

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CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision

27 July 2018

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Regulation of T lymphocyte metabolism

27 July 2018

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Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

27 July 2018

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The CD28 signaling pathway regulates glucose metabolism

27 July 2018

1 reference

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Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924580

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

27 July 2018

1 reference

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Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

27 July 2018

1 reference

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Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development

27 July 2018

1 reference

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Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein

27 July 2018

1 reference

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Bclx regulates the survival of double-positive thymocytes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924580

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924580

Immature CD4 CD8 thymocytes and mature T cells regulate Nur77 distinctly in response to TCR stimulation.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924580

Interplay between RORgammat, Egr3, and E proteins controls proliferation in response to pre-TCR signals.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924580

Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924580

Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924580

Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924580

Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924580

The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924580

Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924580

Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924580

Protein kinase B alpha/Akt1 regulates placental development and fetal growth

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924580

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924580

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924580

Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924580

A matter of life and death

24 September 2018

1 reference

12 December 2020

Differential activation of CREB by Akt1 and Akt2

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12 December 2020

Unequal Contribution of Akt Isoforms in the Double-Negative to Double-Positive Thymocyte Transition

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12 December 2020

Thymopoiesis independent of common lymphoid progenitors

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12 December 2020

Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors

1 reference

12 December 2020

NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0705285104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609365 AND SRC:MED&resulttype=core&format=json

1 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17609365 AND SRC:MED&resulttype=core&format=json

1 January 2020

PubMed publication ID

17609365

1 reference