Extracellular Signal-Regulated Kinases Modulate DNA Damage Response - A Contributing Factor to Using MEK Inhibitors in Cancer Therapy (Q35900578)

11 August 2017

1 reference

8 February 2021

Extracellular signal-regulated kinases modulate DNA damage response - a contributing factor to using MEK inhibitors in cancer therapy (English)

1 reference

11 August 2017

Extracellular Signal-Regulated Kinases Modulate DNA Damage Response - A Contributing Factor to Using MEK Inhibitors in Cancer Therapy (English)

1 reference

10.2174/092986711798194388

Crossref

DOI

https://api.crossref.org/works/10.2174/092986711798194388

17 December 2024

1 reference

24 January 2021

extracellular signal-regulated kinases

1 reference

PubMed

protein kinase inhibitors

28 September 2019

1 reference

2 October 2019

1 reference

8 February 2021

F. Wei

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22087839

17 December 2024

J. Yan

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22087839

17 December 2024

D. Tang

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3

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17 December 2024

language of work or name

English

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22087839

17 December 2024

publication date

1 January 2011

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11 August 2017

2011

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22087839

full work available at URL

17 December 2024

https://europepmc.org/articles/pmc3330700?pdf=render

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22087839

https://europepmc.org/articles/PMC3330700

17 December 2024

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open access

content deliverer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22087839

https://europepmc.org/articles/PMC3330700?pdf=render

17 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22087839

http://eurekaselect.com/article/download/75667

17 December 2024

1 reference

10.2174/092986711798194388

Crossref

DOI

https://api.crossref.org/works/10.2174/092986711798194388

Current Medicinal Chemistry

17 December 2024

published in

7 references

11 August 2017

3 April 2019

28 September 2019

2 October 2019

20 November 2019

24 January 2021

8 February 2021

18

1 reference

11 August 2017

35

1 reference

11 August 2017

5476-5482

1 reference

Creative Commons Attribution 2.5 Generic

11 August 2017

6 references

3 April 2019

28 September 2019

2 October 2019

20 November 2019

24 January 2021

on focus list of Wikimedia project

8 February 2021

ScienceSource

0 references

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Cyclin-dependent kinases (cdks) and the DNA damage response: rationale for cdk inhibitor–chemotherapy combinations as an anticancer strategy for solid tumors

11 July 2018

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DNA Damage–Induced Modulation of GLUT3 Expression Is Mediated through p53-Independent Extracellular Signal-Regulated Kinase Signaling in HeLa Cells

11 July 2018

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ERK1 and ERK2 kinases activate hydroxyurea-induced S-phase checkpoint in MCF7 cells by mediating ATR activation

11 July 2018

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Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation

11 July 2018

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Requirement of MTA1 in ATR-mediated DNA damage checkpoint function

11 July 2018

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KRAS mutant lung cancer cells are differentially responsive to MEK inhibitor due to AKT or STAT3 activation: implication for combinatorial approach

11 July 2018

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A phase II study of PD-0325901, an oral MEK inhibitor, in previously treated patients with advanced non-small cell lung cancer

11 July 2018

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BRCA1 protein and nucleolin colocalize in breast carcinoma tissue and cancer cell lines

11 July 2018

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Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites

11 July 2018

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Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair.

11 July 2018

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Emerging common themes in regulation of PIKKs and PI3Ks

11 July 2018

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A comparison of BRCA1 nuclear localization with 14 DNA damage response proteins and domains: identification of specific differences between BRCA1 and 53BP1 at DNA damage-induced foci

11 July 2018

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The S-phase checkpoint: targeting the replication fork

11 July 2018

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Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage

11 July 2018

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Ras signaling and therapies

11 July 2018

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The Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damage

11 July 2018

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In vitro and in vivo radiosensitization with AZD6244 (ARRY-142886), an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 kinase

11 July 2018

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Coactivation of ATM/ERK/NF-kappaB in the low-dose radiation-induced radioadaptive response in human skin keratinocytes.

11 July 2018

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Targeting the RAF-MEK-ERK pathway in cancer therapy

11 July 2018

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Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells

11 July 2018

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ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes

11 July 2018

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Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells

11 July 2018

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ATR: an essential regulator of genome integrity

11 July 2018

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TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

11 July 2018

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Substrate discrimination among mitogen-activated protein kinases through distinct docking sequence motifs

11 July 2018

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Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation

11 July 2018

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ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses.

11 July 2018

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Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

11 July 2018

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The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

11 July 2018

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Cisplatin cytotoxicity of auditory cells requires secretions of proinflammatory cytokines via activation of ERK and NF-kappaB.

11 July 2018

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The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

11 July 2018

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Protein trafficking in response to DNA damage

11 July 2018

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Function of a conserved checkpoint recruitment domain in ATRIP proteins

11 July 2018

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Irradiation-induced G2/M checkpoint response requires ERK1/2 activation

11 July 2018

1 reference

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Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response

11 July 2018

1 reference

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Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

11 July 2018

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Regulation of cyclin-dependent kinase 5 and p53 by ERK1/2 pathway in the DNA damage-induced neuronal death

11 July 2018

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An intrinsic cell cycle checkpoint pathway mediated by MEK and ERK in Drosophila.

11 July 2018

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TopBP1 activates the ATR-ATRIP complex

11 July 2018

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BRAF mutation predicts sensitivity to MEK inhibition

11 July 2018

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DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF.

11 July 2018

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Coordinating ERK/MAPK signalling through scaffolds and inhibitors

11 July 2018

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ERK activity facilitates activation of the S-phase DNA damage checkpoint by modulating ATR function

11 July 2018

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Cellular dynamics and modulation of WRN protein is DNA damage specific

11 July 2018

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Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

11 July 2018

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Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling

11 July 2018

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

11 July 2018

1 reference

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Guilty as charged: B-RAF is a human oncogene

11 July 2018

1 reference

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Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer

11 July 2018

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Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis

11 July 2018

1 reference

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Chk1 in the DNA damage response: conserved roles from yeasts to mammals

11 July 2018

1 reference

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Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

PML regulates p53 stability by sequestering Mdm2 to the nucleolus

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Replication protein A-mediated recruitment and activation of Rad17 complexes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

MAPK pathways in radiation responses

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

DNA damage is a novel response to sublytic complement C5b-9-induced injury in podocytes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

The Raf/MEK/ERK pathway: new concepts of activation.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

ATR and ATRIP: partners in checkpoint signaling

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

The DNA damage response: putting checkpoints in perspective

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Requirement for ERK activation in cisplatin-induced apoptosis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Docking domains and substrate-specificity determination for MAP kinases

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

CDK inhibitors: positive and negative regulators of G1-phase progression

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Mitotic and G 2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

A novel mutant allele of Schizosaccharomyces pombe rad26 defective in monitoring S-phase progression to prevent premature mitosis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

The mitogen-activated protein kinase signal transduction pathway

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

A family of human cdc2-related protein kinases

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Phase I pharmacokinetic and pharmacodynamic study of the oral MAPK/ERK kinase inhibitor PD-0325901 in patients with advanced cancers

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Inhibition of MEK signaling enhances the ability of cytarabine to induce growth arrest and apoptosis of acute myelogenous leukemia cells.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Trial offers early test case for personalized medicine

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

KSR1 is required for cell cycle reinitiation following DNA damage

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Delocalization of nucleolar poly(ADP-ribose) polymerase-1 to the nucleoplasm and its novel link to cellular sensitivity to DNA damage

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

How ATR turns on: TopBP1 goes on ATRIP with ATR.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

24 September 2018

How cells activate ATR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3330700

24 September 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/22087839

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A Rad3–Rad26 complex responds to DNA damage independently of other checkpoint proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22087839

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2174/092986711798194388

1 reference

11 August 2017

1 reference

11 August 2017

1 reference