Drug interactions with St John's wort : mechanisms and clinical implications (Q35879020)

10 August 2017

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title

Drug interactions with St John's wort : mechanisms and clinical implications (English)

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10 August 2017

Marcus Mannel

1

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10 August 2017

publication date

1 January 2004

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10 August 2017

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10 August 2017

volume

27

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10 August 2017

issue

11

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10 August 2017

page(s)

773-797

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Effect of St John's wort dose and preparations on the pharmacokinetics of digoxin

10 August 2017

cites work

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12 December 2020

Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe

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12 December 2020

The effect of food components on the absorption of P-gp substrates: a review.

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12 December 2020

Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR.

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12 December 2020

St John's wort: a hidden risk for transplant patients

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12 December 2020

Methadone maintenance treatment and St. John's Wort - a case report

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12 December 2020

Unexplained decrease of cyclosporin trough levels in a compliant renal transplant patient

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12 December 2020

Incidence and clinical relevance of the interactions and side effects of Hypericum preparations

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12 December 2020

Drug interaction of herbal tea containing St. John's wort with cyclosporine

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12 December 2020

The interaction between St John's wort and an oral contraceptive

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12 December 2020

Preoperative use of herbal medicines: a patient survey

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12 December 2020

[St. John's wort extract in the ambulatory therapy of depression. Attention and reaction ability are preserved]

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12 December 2020

Adverse effects profile of the herbal antidepressant St. John's wort (Hypericum perforatum L.).

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12 December 2020

Effect of honey on carbamazepine kinetics in rabbits.

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12 December 2020

St. John's wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature.

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12 December 2020

St. John's wort for depression: a meta-analysis of well-defined clinical trials

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12 December 2020

St John's wort induces both cytochrome P450 3A4-catalyzed sulfoxidation and 2C19-dependent hydroxylation of omeprazole

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12 December 2020

Potential metabolic interaction between St. John's wort and theophylline

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12 December 2020

Delayed emergence and St. John's wort.

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12 December 2020

St. John's wort: a pharmaceutical with potentially dangerous interactions

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12 December 2020

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

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12 December 2020

St. John's wort and oral contraceptives: reasons for concern?

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12 December 2020

Effect of St. John's wort on the pharmacokinetics of theophylline in healthy volunteers

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12 December 2020

Interactions between antiepileptic and chemotherapeutic drugs

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12 December 2020

Single-dose and steady-state pharmacokinetics of hypericin and pseudohypericin

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12 December 2020

Orphan nuclear receptors: the exotics of xenobiotics.

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12 December 2020

Effect of St. John's wort (Hypericum perforatum) on cytochrome P-450 2D6 and 3A4 activity in healthy volunteers

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12 December 2020

Lack of effect of St John's Wort on carbamazepine pharmacokinetics in healthy volunteers

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12 December 2020

Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane

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12 December 2020

Physico-chemical interactions between extracts of Hypericum perforatum L. and drugs

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12 December 2020

Dose-dependent inhibition of theophylline metabolism by disulfiram in recovering alcoholics

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12 December 2020

St. John's wort and antidepressant drug interactions in the elderly

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12 December 2020

A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review

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12 December 2020

Differential effects of Saint John's Wort (hypericum perforatum) on the urinary excretion of D-glucaric acid and 6beta-hydroxycortisol in healthy volunteers

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12 December 2020

Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects

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12 December 2020

Different effects of St John's wort on the pharmacokinetics of simvastatin and pravastatin

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12 December 2020

The peri-operative implications of herbal medicines

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12 December 2020

Effect of St John's wort on the activities of CYP1A2, CYP3A4, CYP2D6, N-acetyltransferase 2, and xanthine oxidase in healthy males and females

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12 December 2020

Sub-chronic treatment with an extract of Hypericum perforatum (St John's wort) significantly reduces cortisol and corticosterone in the rat brain

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12 December 2020

Effect of St. John's Wort extract on intestinal expression of cytochrome P4501A2: studies in LS180 cells.

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12 December 2020

The Effect of Hypericum Extract on Cardiac Conduction as seen in the Electrocardiogram Compared to that of Imipramine

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12 December 2020

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

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12 December 2020

Metabolism of theophylline by cDNA-expressed human cytochromes P-450.

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12 December 2020

Drug interaction between St. John's wort and cyclosporine

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12 December 2020

Impact of St John's wort treatment on the pharmacokinetics of tacrolimus and mycophenolic acid in renal transplant patients

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12 December 2020

Herb-drug interactions: review and assessment of report reliability

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12 December 2020

Pharmacokinetic interactions between herbal remedies and medicinal drugs

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12 December 2020

Differential drug-induced mRNA expression of human CYP3A4 compared to CYP3A5, CYP3A7 and CYP3A43.

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12 December 2020

Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans

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12 December 2020

A pilot study of Hypericum perforatum for the treatment of premenstrual syndrome

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12 December 2020

Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein

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12 December 2020

Evaluation ofin vivo parameters of drug metabolizing enzyme activity in man after administration of clemastine, phenobarbital or placebo

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12 December 2020

SSRIs and St.John's Wort: possible toxicity?

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12 December 2020

Comparing phytopharmaceuticals: the example of St. John's Wort

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12 December 2020

Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity

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12 December 2020

St. John's wort: effect on CYP2D6 activity using dextromethorphan-dextrorphan ratios

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12 December 2020

[St. John's wort: interaction with cyclosporine increases risk of rejection for the kidney transplant and raises daily cost of medication]

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12 December 2020

Influence of honey on orally and intravenously administered diltiazem kinetics in rabbits

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12 December 2020

Psychiatrists' experience and views regarding St John's Wort and 'alternative' treatments

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12 December 2020

St. John's wort in generalized anxiety disorder: three case reports

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12 December 2020

Interaction of rifampicin treatment with pharmacokinetics and metabolism of ethinyloestradiol in man

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12 December 2020

Contraceptive effectiveness: cytochromes and induction

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12 December 2020

St John's wort extract (LI 160) in somatoform disorders: results of a placebo-controlled trial

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12 December 2020

Hazardous pharmacokinetic interaction of Saint John's wort (Hypericum perforatum) with the immunosuppressant cyclosporin.

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12 December 2020

Rapid assessment of P-glycoprotein inhibition and induction in vitro

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12 December 2020

Human liver microsomal enflurane defluorination catalyzed by cytochrome P-450 2E1.

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12 December 2020

The role of multidrug transporters in drug availability, metabolism and toxicity

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12 December 2020

beta-Amyloid efflux mediated by p-glycoprotein

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12 December 2020

Effect of enzyme induction on plasma lipids using antipyrine, phenobarbital, and rifampicin

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12 December 2020

Interaction of Hypericum perforatum (St. John's wort) with cyclosporin A metabolism in a patient after liver transplantation

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12 December 2020

Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures

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12 December 2020

A systematic review of newer pharmacotherapies for depression in adults: evidence report summary

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12 December 2020

Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)

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12 December 2020

Quantitative determination by HPLC of urinary 6?-hydroxycortisol, an indicator of enzyme induction by rifampicin and antiepileptic drugs

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12 December 2020

Second thoughts about safety of St John's wort

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12 December 2020

A possible cause of cardiovascular collapse during anesthesia: long-term use of St. John's Wort

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12 December 2020

Acute heart transplant rejection due to Saint John's wort

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12 December 2020

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

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12 December 2020

Drug interaction of St John's wort with cyclosporin

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12 December 2020

Quantitative characterization of direct P-glycoprotein inhibition by St John's wort constituents hypericin and hyperforin

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12 December 2020

St John's wort, a herbal antidepressant, activates the steroid X receptor.

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12 December 2020

Tacrolimus-induced nephrotoxicity unmasked by induction of the CYP3A4 system with St John's wort

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12 December 2020

Interaction between cyclosporine and Hypericum perforatum (St. John's wort) after organ transplantation

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12 December 2020

Mania in a patient receiving testosterone replacement postorchidectomy taking St John's wort and sertraline.

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12 December 2020

Potentially serious drug interactions between St John's Wort and other medicines

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12 December 2020

Synergistic toxicity of delta-aminolaevulinic acid-induced protoporphyrin IX used for photodiagnosis and hypericum extract, a herbal antidepressant

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12 December 2020

Profound drop of cyclosporin A whole blood trough levels caused by St. John's wort (Hypericum perforatum)

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12 December 2020

St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

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12 December 2020

Hyperforin contributes to the hepatic CYP3A-inducing effect of Hypericum perforatum extract in the mouse

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12 December 2020

Interphenotype differences in disposition and effect on gastrin levels of omeprazole—suitability of omeprazole as a probe for CYP2C19

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12 December 2020

Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans

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12 December 2020

Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression.

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12 December 2020

The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity

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12 December 2020

[St. Johns wort-venlafaxine interaction]

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12 December 2020

Treatment of somatoform disorders with St. John's wort: a randomized, double-blind and placebo-controlled trial

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12 December 2020

Alterations in cyclosporin A pharmacokinetics and metabolism during treatment with St John's wort in renal transplant patients

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12 December 2020

Short term treatment with St. John's wort, hypericin or hyperforin fails to induce CYP450 isoforms in the Swiss Webster mouse.

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12 December 2020

St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties.

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12 December 2020

Reversal by phenytoin of carbamazepine-induced water intoxication: a pharmacokinetic interaction

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12 December 2020

Interactions of herbs with cytochrome P450.

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12 December 2020

St. John's wort extract induces CYP3A and CYP2E1 in the Swiss Webster mouse

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12 December 2020

Low cyclosporin-A level due to Saint-John's-wort in heart transplant patients

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12 December 2020

Effect of St John's wort on the pharmacokinetics of fexofenadine

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12 December 2020

Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor

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12 December 2020

St Johns wort increases expression of P-glycoprotein: implications for drug interactions

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12 December 2020

St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism

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12 December 2020

Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors

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12 December 2020

The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

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12 December 2020

Effects of St. John's wort on irinotecan metabolism

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12 December 2020

Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers

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12 December 2020

Antidepressant activity of hypericum perforatum and hyperforin: the neglected possibility

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12 December 2020

Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme

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12 December 2020

Possible serotonin syndrome after combination of buspirone and St John's Wort

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12 December 2020

Herbal medicines and perioperative care

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12 December 2020

Interaction of St John's wort with low‐dose oral contraceptive therapy: a randomized controlled trial

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12 December 2020

Experience with St John's Wort (Hypericum perforatum) in children under 12 years with symptoms of depression and psychovegetative disturbances

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12 December 2020

St John's Wort: effect on CYP3A4 activity

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12 December 2020

Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids

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12 December 2020

Pharmacodynamic properties of St. John's wort-A single blind neurophysiological study in healthy subjects comparing two commercial preparations.

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12 December 2020

Oxidation of 17 alpha-ethynylestradiol by human liver cytochrome P-450

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12 December 2020

A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients

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12 December 2020

Catalytic inhibition of human DNA topoisomerase IIalpha by hypericin, a naphthodianthrone from St. John's wort (Hypericum perforatum).

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12 December 2020

Hypericum perforatum (St John's wort) in depression: pest or blessing?

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12 December 2020

St John's wort (Hypericum perforatum): drug interactions and clinical outcomes

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12 December 2020

Drug interactions between antiretroviral drugs and comedicated agents

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12 December 2020

D-glucaric acid excretion in critical care patients--comparison with 6 beta-hydroxycortisol excretion and serum gamma-glutamyltranspeptidase activity and relation to multiple drug therapy

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12 December 2020

St. John's wort and depression: efficacy, safety and tolerability-an update

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12 December 2020

Herb-drug, food-drug, nutrient-drug, and drug-drug interactions: mechanisms involved and their medical implications

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12 December 2020

An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures

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12 December 2020

Herbal medicines as a factor in delirium

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12 December 2020

Influence of phenobarbital and diphenylhydantoin on plasma carbamazepine levels in patients with epilepsy

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12 December 2020

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

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12 December 2020

Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from St. John's wort ( Hypericum perforatum ).

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12 December 2020

Adverse reactions to St John's Wort.

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12 December 2020

Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure

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12 December 2020

Five Distinct Human Cytochromes Mediate Amitriptyline N‐Demethylation In Vitro: Dominance of CYP 2C19 and 3A4

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12 December 2020

Drug interaction between St John's wort and nevirapine

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12 December 2020

Cluster analysis of symptoms during antidepressant treatment with Hypericum extract in mildly to moderately depressed out-patients. A meta-analysis of data from three randomized, placebo-controlled trials.

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12 December 2020

Red wine decreases cyclosporine bioavailability

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12 December 2020

An open-label trial of St. John's Wort (Hypericum perforatum) in obsessive-compulsive disorder

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12 December 2020

Effects of two different extracts of St. John's wort and some of their constituents on cytochrome P450 activities in rat liver microsomes

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12 December 2020

Consumer use of St. John's wort: a survey on effectiveness, safety, and tolerability

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12 December 2020

Safety of St John's wort (Hypericum perforatum)

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12 December 2020

Current St John's wort research from mode of action to clinical efficacy

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12 December 2020

St. John's wort extracts and some of their constituents potently inhibit ultimate carcinogen formation from benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1.

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12 December 2020

Effect of soy milk on warfarin efficacy

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12 December 2020

Unwanted pregnancy on self-medication with St John's wort despite hormonal contraception

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12 December 2020

Indinavir concentrations and St John's wort.

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12 December 2020

A nuclear receptor-mediated xenobiotic response and its implication in drug metabolism and host protection.

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12 December 2020

10.2165/00002018-200427110-00003

Identifiers

DOI

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Dimensions Publication ID

10 August 2017

1025112030

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