The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing (Q35860403)

10 August 2017

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title

The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing (English)

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10 August 2017

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Rupert Abele

1

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10 August 2017

Robert Tampé

series ordinal

2

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10 August 2017

language of work or name

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1 August 2004

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10 August 2017

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10 August 2017

volume

19

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10 August 2017

page(s)

216-224

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Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens

10 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Distinct functional properties of the TAP subunits coordinate the nucleotide-dependent transport cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

An early pseudorabies virus protein down-regulates porcine MHC class I expression by inhibition of transporter associated with antigen processing (TAP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Human transporters associated with antigen processing possess a promiscuous peptide-binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Use of chimeric proteins to investigate the role of transporter associated with antigen processing (TAP) structural domains in peptide binding and translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

The N-terminal region of tapasin is required to stabilize the MHC class I loading complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C‐terminal tails of TAP1 and TAP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Mutations within the first LSGGQ motif of Ste6p cause defects in a-factor transport and mating in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

A Tweezers-like Motion of the ATP-Binding Cassette Dimer in an ABC Transport Cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Peptides induce ATP hydrolysis at both subunits of the transporter associated with antigen processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Functional asymmetry of the ATP-binding-cassettes of the ABC transporter TAP is determined by intrinsic properties of the nucleotide binding domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Homozygous human TAP peptide transporter mutation in HLA class I deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Disulfide bond isomerization and the assembly of MHC class I-peptide complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Vanadate-catalyzed photocleavage of the signature motif of an ATP-binding cassette (ABC) transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

A viral inhibitor of peptide transporters for antigen presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Transcriptional regulation of the major histocompatibility complex (MHC) class I heavy chain, TAP1 and LMP2 genes by the human papillomavirus (HPV) type 6b, 16 and 18 E7 oncoproteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Allosteric crosstalk between peptide-binding, transport, and ATP hydrolysis of the ABC transporter TAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Regulation of MHC class I heterodimer stability and interaction with TAP by tapasin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Antigen degradation or presentation by MHC class I molecules via classical and non-classical pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

A viral ER-resident glycoprotein inactivates the MHC-encoded peptide transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

The human cytomegalovirus gene product US6 inhibits ATP binding by TAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

ABC Transporters: From Microorganisms to Man

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Herpes simplex virus turns off the TAP to evade host immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Nucleotide Dependent Monomer/Dimer Equilibrium of OpuAA, the Nucleotide-binding Protein of the Osmotically Regulated ABC Transporter OpuA from Bacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Phagosomes are competent organelles for antigen cross-presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Distinct functions and cooperative interaction of the subunits of the transporter associated with antigen processing (TAP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Nucleotide binding by TAP mediates association with peptide and release of assembled MHC class I molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Bovine herpesvirus 1 interferes with TAP-dependent peptide transport and intracellular trafficking of MHC class I molecules in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Molecular mechanism and structural aspects of transporter associated with antigen processing inhibition by the cytomegalovirus protein US6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Herpes simplex virus inhibitor ICP47 destabilizes the transporter associated with antigen processing (TAP) heterodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

The transporter associated with antigen processing: function and implications in human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Walker A lysine mutations of TAP1 and TAP2 interfere with peptide translocation but not peptide binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Nucleotide interactions with membrane-bound transporter associated with antigen processing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Tapasin enhances assembly of transporters associated with antigen processing-dependent and -independent peptides with HLA-A2 and HLA-B27 expressed in insect cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line .220.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Tapasin is required for efficient peptide binding to transporter associated with antigen processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Virus subversion of the MHC class I peptide-loading complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Mobilization of MHC class I molecules from late endosomes to the cell surface following activation of CD34-derived human Langerhans cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Downregulation of the proteasome subunits, transporter, and antigen presentation in hepatocellular carcinoma, and their restoration by interferon-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Dendritic cells: specialized and regulated antigen processing machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Tapasin-the keystone of the loading complex optimizing peptide binding by MHC class I molecules in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

The active domain of the herpes simplex virus protein ICP47: a potent inhibitor of the transporter associated with antigen processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Kinetic analysis of peptide binding to the TAP transport complex: evidence for structural rearrangements induced by substrate binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

The ATP/substrate stoichiometry of the ATP-binding cassette (ABC) transporter OpuA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Structure of the active domain of the herpes simplex virus protein ICP47 in water/sodium dodecyl sulfate solution determined by nuclear magnetic resonance spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Quantitating protein synthesis, degradation, and endogenous antigen processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Quantitative and qualitative influences of tapasin on the class I peptide repertoire.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Tapasin interacts with the membrane-spanning domains of both TAP subunits and enhances the structural stability of TAP1 x TAP2 Complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Distinct functions of the ATP binding cassettes of transporters associated with antigen processing: a mutational analysis of Walker A and B sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Retention of empty MHC class I molecules by tapasin is essential to reconstitute antigen presentation in invertebrate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

SWISS-MODEL: An automated protein homology-modeling server

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Recognition principle of the TAP transporter disclosed by combinatorial peptide libraries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Requirements for peptide binding to the human transporter associated with antigen processing revealed by peptide scans and complex peptide libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

A sequential model for peptide binding and transport by the transporters associated with antigen processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Characterization of site-directed mutations in conserved domains of MalK, a bacterial member of the ATP-binding cassette (ABC) family [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Optimization of the MHC class I peptide cargo is dependent on tapasin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

A single-nucleotide deletion leads to rapid degradation of TAP-1 mRNA in a melanoma cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Tapasin is a facilitator, not an editor, of class I MHC peptide binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

Growing pains of a genomics industry

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

The major substrates for TAP in vivo are derived from newly synthesized proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/PHYSIOL.00002.2004

10.1152/PHYSIOL.00002.2004

21 January 2018

Identifiers

DOI

1 reference

10 August 2017

1 reference