Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment (Q35853020)

10 August 2017

Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment (English)

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10 August 2017

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Edward Rockenstein

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Eliezer Masliah

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10 August 2017

Anne-Maria Poehler

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10 August 2017

Wei Xiang

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Philipp Spitzer

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Verena Elisabeth Luise May

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10 August 2017

Holger Meixner

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Oldriska Chutna

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10 August 2017

Tiago Fleming Outeiro

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Juergen Winkler

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Jochen Klucken

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1 January 2014

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2171-2192

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describes a project that uses

10 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4502760/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein.

11 July 2018

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Oxidative stress-induced posttranslational modifications of alpha-synuclein: specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity.

11 July 2018

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Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

11 July 2018

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Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia.

11 July 2018

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Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission

11 July 2018

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Guidelines for the use and interpretation of assays for monitoring autophagy

11 July 2018

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Exosomal cell-to-cell transmission of alpha synuclein oligomers.

11 July 2018

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Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.

11 July 2018

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Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo

11 July 2018

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Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway

11 July 2018

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Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

11 July 2018

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The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein.

11 July 2018

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Assessment of α-synuclein secretion in mouse and human brain parenchyma

11 July 2018

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In vivo demonstration that alpha-synuclein oligomers are toxic

11 July 2018

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Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.

11 July 2018

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

11 July 2018

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Cell-to-cell transmission of non-prion protein aggregates.

11 July 2018

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Heat‐shock protein 70 modulates toxic extracellular α‐synuclein oligomers and rescues trans‐synaptic toxicity

11 July 2018

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Chaperone-mediated autophagy markers in Parkinson disease brains

11 July 2018

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Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

11 July 2018

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Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy

11 July 2018

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Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies

11 July 2018

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Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

11 July 2018

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Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

11 July 2018

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Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle

11 July 2018

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Cell-derived microparticles: a new challenge in neuroscience

11 July 2018

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Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy

11 July 2018

1 reference

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Shedding microvesicles: artefacts no more

11 July 2018

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Autophagy and multivesicular bodies: two closely related partners

11 July 2018

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Proteomic profiling of exosomes: current perspectives

11 July 2018

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Proteasomal abnormalities in cortical Lewy body disease and the impact of proteasomal inhibition within cortical and cholinergic systems

11 July 2018

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Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells

11 July 2018

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Potential therapeutic applications of autophagy

11 July 2018

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The roles of intracellular protein-degradation pathways in neurodegeneration

11 July 2018

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Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection

11 July 2018

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Maturation of autophagic vacuoles in Mammalian cells

11 July 2018

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Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

11 July 2018

1 reference

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Rab11 promotes docking and fusion of multivesicular bodies in a calcium-dependent manner

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

Molecular Pathways of Neurodegeneration in Parkinson's Disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

Staging of brain pathology related to sporadic Parkinson's disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

Heterogeneity of nigral and cortical Lewy bodies differentiated by amplified triple-labeling for alpha-synuclein, ubiquitin, and thiazin red.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

α-Synuclein in Lewy bodies

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

Studies on the mechanisms of autophagy: maturation of the autophagic vacuole

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

Conserved High Affinity Ligand Binding and Membrane Association in the Native and Refolded Extracellular Domain of the Human Glycine Receptor α1-Subunit

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502760

Chaperone-Mediated Autophagy

24 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.4161/AUTO.36436

alpha-synuclein degradation by autophagic pathways: a potential key to Parkinson's disease pathogenesis.

21 January 2018

1 reference

12 December 2020

Synphilin-1 is present in Lewy bodies in Parkinson's disease

1 reference

12 December 2020

Increased membrane shedding--indicated by an elevation of CD133-enriched membrane particles--into the CSF in partial epilepsy

1 reference

12 December 2020

Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease

1 reference

12 December 2020

Exosome formation during maturation of mammalian and avian reticulocytes: evidence that exosome release is a major route for externalization of obsolete membrane proteins

1 reference

12 December 2020

Identifiers

DOI

10.4161/AUTO.36436

1 reference

10 August 2017

1 reference

10 August 2017

PubMed publication ID

25484190

1 reference