Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action (Q35850522)

10 August 2017

Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action (English)

1 reference

10 August 2017

Katarzyna Malarz

3

0 references

Vladimír Kryštof

series ordinal

6

object named as

Vladimír Kryštof

1 reference

10 August 2017

7

Robert Musiol

1 reference

10 August 2017

Anna Mrozek-Wilczkiewicz

series ordinal

1

object named as

Anna Mrozek-Wilczkiewicz

1 reference

10 August 2017

5

Marzena Rams-Baron

1 reference

10 August 2017

4

Wioleta Cieslik

1 reference

10 August 2017

Ewelina Spaczynska

2

1 reference

10 August 2017

language of work or name

English

0 references

publication date

23 November 2015

1 reference

10 August 2017

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10 August 2017

10

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10 August 2017

11

1 reference

10 August 2017

e0142678

1 reference

Creative Commons Attribution 4.0 International

10 August 2017

start time

23 November 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Synthesis of New Styrylquinoline Cellular Dyes, Fluorescent Properties, Cellular Localization and Cytotoxic Behavior

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11 July 2018

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A Novel Anticancer Agent, 8-Methoxypyrimido[4",5":4,5]thieno(2,3-b) Quinoline-4(3H)-One Induces Neuro 2a Neuroblastoma Cell Death through p53-Dependent, Caspase-Dependent and -Independent Apoptotic Pathways

11 July 2018

1 reference

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Privileged structures - dream or reality: preferential organization of azanaphthalene scaffold.

11 July 2018

1 reference

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Therapeutic reactivation of mutant p53 protein by quinazoline derivatives

11 July 2018

1 reference

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Quinoline as a Privileged Scaffold in Cancer Drug Discovery

11 July 2018

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Reactivation of p53: from peptides to small molecules.

11 July 2018

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p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma

11 July 2018

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11 July 2018

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Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones

11 July 2018

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Therapeutic targeting of p53 by small molecules.

11 July 2018

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Anticancer DNA intercalators cause p53-dependent mitochondrial DNA nucleoid re-modelling

11 July 2018

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Mitochondrial DNA is a direct target of anti-cancer anthracycline drugs

11 July 2018

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p53 as a therapeutic target.

11 July 2018

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Investigating the antiproliferative activity of quinoline-5,8-diones and styrylquinolinecarboxylic acids on tumor cell lines.

11 July 2018

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Delivery of drugs and macromolecules to mitochondria

11 July 2018

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Investigating biological activity spectrum for novel quinoline analogues

11 July 2018

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Synthesis and evaluation of antitumor activity of novel N-acyllavendamycin analogues and quinoline-5,8-diones

11 July 2018

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Novel lavendamycin analogues as antitumor agents: synthesis, in vitro cytotoxicity, structure-metabolism, and computational molecular modeling studies with NAD(P)H:quinone oxidoreductase 1.

11 July 2018

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Analogues of the styrylquinoline and styrylquinazoline HIV-1 integrase inhibitors: design and synthetic problems.

11 July 2018

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Styrylquinolines, integrase inhibitors acting prior to integration: a new mechanism of action for anti-integrase agents

11 July 2018

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Mechanisms of caspase activation

11 July 2018

1 reference

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CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death

11 July 2018

1 reference

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Small molecules that reactivate mutant p53.

11 July 2018

1 reference

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Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.

11 July 2018

1 reference

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The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein

11 July 2018

1 reference

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Molecular characterization of mitochondrial apoptosis-inducing factor

11 July 2018

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Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

11 July 2018

1 reference

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Styrylquinoline Derivatives: A New Class of Potent HIV-1 Integrase Inhibitors That Block HIV-1 Replication in CEM Cells

11 July 2018

1 reference

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p53 Promotes cell survival due to the reversibility of its cell-cycle checkpoints

11 July 2018

1 reference

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Investigating the activity spectrum for ring-substituted 8-hydroxyquinolines.

24 September 2018

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Investigating biological activity spectrum for novel styrylquinazoline analogues.

24 September 2018

1 reference

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Investigating biological activity spectrum for novel quinoline analogues 2: hydroxyquinolinecarboxamides with photosynthesis-inhibiting activity

24 September 2018

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Antifungal properties of new series of quinoline derivatives

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657899

Characterization of the cytotoxic activities of novel analogues of the antitumor agent, lavendamycin

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657899

The p53 stabilizing compound CP-31398 induces apoptosis by activating the intrinsic Bax/mitochondrial/caspase-9 pathway.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657899

Contribution to investigation of antimicrobial activity of styrylquinolines

24 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0142678

CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26599982

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Drug discovery in the p53 field

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26599982

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26599982

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0142678

1 reference

10 August 2017

0 references

1 reference

10 August 2017

PubMed publication ID

26599982

1 reference