Altered human CYP3A4 activity caused by Antley-Bixler syndrome-related variants of NADPH-cytochrome P450 oxidoreductase measured in a robust in vitro system (Q35846903)

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scientific article published on 17 January 2012

Language	Label	Description	Also known as
English	Altered human CYP3A4 activity caused by Antley-Bixler syndrome-related variants of NADPH-cytochrome P450 oxidoreductase measured in a robust in vitro system	scientific article published on 17 January 2012

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scholarly article

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Europe PubMed Central

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20 January 2020

Altered human CYP3A4 activity caused by Antley-Bixler syndrome-related variants of NADPH-cytochrome P450 oxidoreductase measured in a robust in vitro system (English)

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20 January 2020

4

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20 January 2020

5

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20 January 2020

Michel Kranendonk

7

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20 January 2020

author name string

Daniela Moutinho

1

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20 January 2020

Christopher C Marohnic

2

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20 January 2020

Satya P Panda

3

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20 January 2020

Bettie Sue Masters

6

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20 January 2020

publication date

17 January 2012

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20 January 2020

Drug Metabolism and Disposition

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20 January 2020

40

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20 January 2020

4

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20 January 2020

754-760

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20 January 2020

Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency

1 reference

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Mutations of human cytochrome P450 reductase differentially modulate heme oxygenase-1 activity and oligomerization

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CYP3A5-mediated metabolism of midazolam in recombinant systems is highly sensitive to NADPH-cytochrome P450 reductase activity

1 reference

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Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro

1 reference

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Reduction in hepatic drug metabolizing CYP3A4 activities caused by P450 oxidoreductase mutations identified in patients with disordered steroid metabolism

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11 July 2018

Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase

1 reference

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11 July 2018

Human cytochrome P450 oxidoreductase deficiency caused by the Y181D mutation: molecular consequences and rescue of defect.

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Domain motion in cytochrome P450 reductase: conformational equilibria revealed by NMR and small-angle x-ray scattering.

1 reference

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Structure of the open conformation of a functional chimeric NADPH cytochrome P450 reductase

1 reference

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Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation

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11 July 2018

Structure and Function of an NADPH-Cytochrome P450 Oxidoreductase in an Open Conformation Capable of Reducing Cytochrome P450

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Genetic polymorphisms in cytochrome P450 oxidoreductase influence microsomal P450-catalyzed drug metabolism.

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Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase

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11 July 2018

Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis

1 reference

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11 July 2018

Cytochrome P450 oxidoreductase gene mutations and Antley-Bixler syndrome with abnormal genitalia and/or impaired steroidogenesis: molecular and clinical studies in 10 patients.

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11 July 2018

Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study

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Pharmacogenomics--drug disposition, drug targets, and side effects

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11 July 2018

Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochromes P-450.

1 reference

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11 July 2018

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism

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11 July 2018

Three-dimensional structure of NADPH–cytochrome P450 reductase: Prototype for FMN- and FAD-containing enzymes

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11 July 2018

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1 reference

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11 July 2018

NADPH-cytochrome P-450 oxidoreductase gene organization correlates with structural domains of the protein

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Identification of the high and low potential flavins of liver microsomal NADPH-cytochrome P-450 reductase

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Measurement of cytochrome P450 and NADPH-cytochrome P450 reductase

1 reference

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24 September 2018

Effects of enzyme sources on midazolam 1'-hydroxylation activity catalyzed by recombinant cytochrome P450 3A4 in combination with NADPH-cytochrome P450 reductase

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Pharmacogenetics of P450 oxidoreductase: effect of sequence variants on activities of CYP1A2 and CYP2C19.

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Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase.

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Diminished FAD binding in the Y459H and V492E Antley-Bixler syndrome mutants of human cytochrome P450 reductase

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Differential Inhibition of CYP17A1 and CYP21A2 Activities by the P450 Oxidoreductase Mutant A287P

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Identifiers

10.1124/DMD.111.042820

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20 January 2020

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20 January 2020

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20 January 2020

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