The Fanconi Anemia Pathway Protects Genome Integrity from R-loops (Q35846161)

10 August 2017

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops (English)

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10 August 2017

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1

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7 June 2020

Sonia Barroso

3

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7 June 2020

Emanuela Tumini

4

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7 June 2020

Emilia Herrera-Moyano

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7 June 2020

Ivan V Rosado

6

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7 June 2020

Andrés Aguilera

7

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7 June 2020

author name string

Carmen Pérez-Calero

2

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7 June 2020

publication date

19 November 2015

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10 August 2017

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7 June 2020

volume

11

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issue

11

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7 June 2020

page(s)

e1005674

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Creative Commons Attribution 4.0 International

7 June 2020

copyright license

start time

19 November 2015

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

R loops: new modulators of genome dynamics and function

1 reference

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BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair

11 July 2018

1 reference

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Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability

11 July 2018

1 reference

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R-loops induce repressive chromatin marks over mammalian gene terminators

11 July 2018

1 reference

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BRCA1 pathway function in basal-like breast cancer cells

11 July 2018

1 reference

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A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression

11 July 2018

1 reference

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R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.

11 July 2018

1 reference

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The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts

11 July 2018

1 reference

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R loops are linked to histone H3 S10 phosphorylation and chromatin condensation

11 July 2018

1 reference

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Causes of genome instability

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Transcription-associated genome instability

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Fanconi anaemia and the repair of Watson and Crick DNA crosslinks

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes

11 July 2018

1 reference

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R loops: from transcription byproducts to threats to genome stability

11 July 2018

1 reference

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R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters

11 July 2018

1 reference

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R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants

11 July 2018

1 reference

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RNase H and Multiple RNA Biogenesis Factors Cooperate to Prevent RNA:DNA Hybrids from Generating Genome Instability

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Genome instability and transcription elongation impairment in human cells depleted of THO/TREX

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

R-loop-mediated genomic instability is caused by impairment of replication fork progression

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

11 July 2018

1 reference

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Yeast Sen1 helicase protects the genome from transcription-associated instability.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

FANCD2 hurdles the DNA interstrand crosslink

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Premature condensation induces breaks at the interface of early and late replicating chromosome bands bearing common fragile sites

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

11 July 2018

1 reference

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ATR couples FANCD2 monoubiquitination to the DNA-damage response

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated Recombination

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

FANCE: the link between Fanconi anaemia complex assembly and activity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Biallelic inactivation of BRCA2 in Fanconi anemia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

The involvement of human ribonucleases H1 and H2 in the variation of response of cells to antisense phosphorothioate oligonucleotides

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Positional cloning of a novel Fanconi anemia gene, FANCD2

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4652862

10.1371/JOURNAL.PGEN.1005674

24 September 2018

Identifiers

DOI

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release_pnq6rcp2ezdabb5jowllyusjbq

7 June 2020

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24 November 2022

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7 June 2020

PubMed publication ID

26584049

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