Gating currents from Kv7 channels carrying neuronal hyperexcitability mutations in the voltage-sensing domain. (Q35843838)

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27 January 2020

title

Gating currents from Kv7 channels carrying neuronal hyperexcitability mutations in the voltage-sensing domain (English)

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27 January 2020

1

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27 January 2020

author name string

Ernesto Vargas

series ordinal

2

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27 January 2020

Francisco Bezanilla

series ordinal

3

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27 January 2020

Maurizio Taglialatela

series ordinal

4

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27 January 2020

language of work or name

English

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publication date

20 March 2012

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27 January 2020

number of pages

11

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based on heuristic

inferred from page(s)

published in

Biophysical Journal

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27 January 2020

volume

102

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27 January 2020

issue

6

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27 January 2020

page(s)

1372-1382

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Driving with no brakes: molecular pathophysiology of Kv7 potassium channels

27 January 2020

cites work

1 reference

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The Voltage-Sensing Domain of K(v)7.2 Channels as a Molecular Target for Epilepsy-Causing Mutations and Anticonvulsants.

11 July 2018

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Control of a final gating charge transition by a hydrophobic residue in the S2 segment of a K channel voltage sensor

11 July 2018

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Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology

11 July 2018

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Targeting the voltage sensor of Kv7.2 voltage-gated K channels with a new gating-modifier

11 July 2018

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Ion permeation and block of the gating pore in the voltage sensor of NaV1.4 channels with hypokalemic periodic paralysis mutations

11 July 2018

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Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement

11 July 2018

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A Gating Charge Transfer Center in Voltage Sensors

11 July 2018

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An intersubunit interaction between S4-S5 linker and S6 is responsible for the slow off-gating component in Shaker K channels

11 July 2018

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Voltage-sensor mutations in channelopathies of skeletal muscle

11 July 2018

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Muscle channelopathies: does the predicted channel gating pore offer new treatment insights for hypokalaemic periodic paralysis?

11 July 2018

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Double gaps along Shaker S4 demonstrate omega currents at three different closed states

11 July 2018

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Neutralization of a unique, negatively-charged residue in the voltage sensor of K V 7.2 subunits in a sporadic case of benign familial neonatal seizures

11 July 2018

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Depolarization-activated gating pore current conducted by mutant sodium channels in potassium-sensitive normokalemic periodic paralysis

11 July 2018

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Determinants within the turret and pore-loop domains of KCNQ3 K channels governing functional activity.

11 July 2018

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Gating consequences of charge neutralization of arginine residues in the S4 segment of K(v)7.2, an epilepsy-linked K channel subunit

11 July 2018

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Dynamics of the Kv1.2 voltage-gated K channel in a membrane environment

11 July 2018

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A Na channel mutation linked to hypokalemic periodic paralysis exposes a proton-selective gating pore

11 July 2018

1 reference

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Atypical gating of M-type potassium channels conferred by mutations in uncharged residues in the S4 region of KCNQ2 causing benign familial neonatal convulsions.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel

11 July 2018

1 reference

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The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes

11 July 2018

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Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Decreased subunit stability as a novel mechanism for potassium current impairment by a KCNQ2 C terminus mutation causing benign familial neonatal convulsions

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Molecular basis of an inherited epilepsy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Scanning the intracellular S6 activation gate in the shaker K channel

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Benign familial neonatal convulsions caused by altered gating of KCNQ2/KCNQ3 potassium channels

11 July 2018

1 reference

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M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain.

11 July 2018

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Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K channel

11 July 2018

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Histidine scanning mutagenesis of basic residues of the S4 segment of the shaker k channel

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Determinants of voltage-dependent gating and open-state stability in the S5 segment of Shaker potassium channels

11 July 2018

1 reference

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Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation

11 July 2018

1 reference

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Voltage-insensitive gating after charge-neutralizing mutations in the S4 segment of Shaker channels

11 July 2018

1 reference

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Cut-open oocyte voltage-clamp technique

11 July 2018

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Activation and inactivation of homomeric KvLQT1 potassium channels.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Uncharged S4 Residues and Cooperativity in Voltage-dependent Potassium Channel Activation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

A potassium channel mutation in neonatal human epilepsy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Contribution of the S4 segment to gating charge in the Shaker K channel.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Molecular basis of charge movement in voltage-gated sodium channels

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

S4 mutations alter gating currents of Shaker K channels

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Electrostatic interactions of S4 voltage sensor in shaker K channel

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Novel voltage clamp to record small, fast currents from ion channels expressed in Xenopus oocytes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Gating currents from neuronal K(V)7.4 channels: general features and correlation with the ionic conductance.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Germ-line mutation of KCNQ2, p.R213W, in a Japanese family with benign familial neonatal convulsion.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Peripheral nerve hyperexcitability due to dominant-negative KCNQ2 mutations

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Gating pore current in an inherited ion channelopathy

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K(v) channel

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

KCNQ channels mediate IKs, a slow K current regulating excitability in the rat node of Ranvier

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Focused electric field across the voltage sensor of potassium channels

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Ion permeation through a voltage- sensitive gating pore in brain sodium channels having voltage sensor mutations

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Voltage sensor of Kv1.2: structural basis of electromechanical coupling

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Three mechanisms underlie KCNQ2/3 heteromeric potassium M-channel potentiation.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Single-channel analysis of KCNQ K channels reveals the mechanism of augmentation by a cysteine-modifying reagent.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

A proton pore in a potassium channel voltage sensor reveals a focused electric field

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

KCNQ2 is a nodal K channel.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Transmembrane movement of the shaker K channel S4.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

Voltage-sensing residues in the S2 and S4 segments of the Shaker K channel

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3309409

10.1016/J.BPJ.2012.02.004

24 September 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22455920 AND SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22455920 AND SRC:MED&resulttype=core&format=json

27 January 2020

PubMed publication ID

22455920

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22455920 AND SRC:MED&resulttype=core&format=json