Thermal proteome profiling monitors ligand interactions with cellular membrane proteins. (Q35829229)

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28 February 2020

title

Thermal proteome profiling monitors ligand interactions with cellular membrane proteins (English)

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2

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Wolfgang Huber

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28 February 2020

Marcus Bantscheff

9

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Gerard Drewes

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author name string

Friedrich B M Reinhard

1

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28 February 2020

Thilo Werner

3

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Holger Franken

4

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Dorothee Childs

5

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Carola Doce

6

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Maria Fälth Savitski

7

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Mikhail M Savitski

10

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publication date

2 November 2015

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volume

12

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issue

12

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page(s)

1129-1131

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Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.

28 February 2020

cites work

1 reference

Tracking cancer drugs in living cells by thermal profiling of the proteome

21 January 2018

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Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

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The cellular thermal shift assay for evaluating drug target interactions in cells

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NQO2 is a reactive oxygen species generating off-target for acetaminophen.

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Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry.

21 January 2018

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How many drug targets are there?

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Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

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Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

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Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation

21 January 2018

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Large-scale proteomic analysis of tyrosine-phosphorylation induced by T-cell receptor or B-cell receptor activation reveals new signaling pathways

21 January 2018

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Role of oxidative stress in the action of vanadium phosphotyrosine phosphatase inhibitors. Redox independent activation of NF-kappaB.

21 January 2018

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Inhibition ofMycobacterium tuberculosisTransaminase BioA by Aryl Hydrazines and Hydrazides

21 January 2018

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Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans

21 January 2018

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Pervanadate stabilizes desmosomes.

21 January 2018

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The structure of phosphoinositide phosphatases: Insights into substrate specificity and catalysis

21 January 2018

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Crystal structure of the high-affinity Na ,K -ATPase-ouabain complex with Mg2 bound in the cation binding site

21 January 2018

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Selective inhibition of MDR1 P-glycoprotein-mediated transport by the acridone carboxamide derivative GG918.

21 January 2018

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Affinity profiling of the cellular kinome for the nucleotide cofactors ATP, ADP, and GTP.

21 January 2018

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Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.

21 January 2018

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Ion coalescence of neutron encoded TMT 10-plex reporter ions.

21 January 2018

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Targeted data acquisition for improved reproducibility and robustness of proteomic mass spectrometry assays

21 January 2018

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Measuring and managing ratio compression for accurate iTRAQ/TMT quantification

21 January 2018

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Protter: interactive protein feature visualization and integration with experimental proteomic data

21 January 2018

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Delayed fragmentation and optimized isolation width settings for improvement of protein identification and accuracy of isobaric mass tag quantification on Orbitrap-type mass spectrometers

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26524241

12 December 2020

inferred from PubMed ID database lookup

A network analysis of changes in molecular interactions in cellular signaling

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26524241

12 December 2020

inferred from PubMed ID database lookup

Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26524241

12 December 2020

inferred from PubMed ID database lookup

Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling.

1 reference

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NMETH.3652

1 reference

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28 February 2020

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