Simvastatin does not influence the intestinal P-glycoprotein and MPR2, and the disposition of talinolol after chronic medication in healthy subjects genotyped for the ABCB1, ABCC2 and SLCO1B1 polymorphisms. (Q35827517)

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scientific article published in April 2006

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English	Simvastatin does not influence the intestinal P-glycoprotein and MPR2, and the disposition of talinolol after chronic medication in healthy subjects genotyped for the ABCB1, ABCC2 and SLCO1B1 polymorphisms.	scientific article published in April 2006

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18 January 2020

Simvastatin does not influence the intestinal P-glycoprotein and MPR2, and the disposition of talinolol after chronic medication in healthy subjects genotyped for the ABCB1, ABCC2 and SLCO1B1 polymorphisms (English)

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18 January 2020

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Ingolf Cascorbi

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18 January 2020

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Annika Bernsdorf

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18 January 2020

Thomas Giessmann

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18 January 2020

Christiane Modess

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18 January 2020

Danilo Wegner

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18 January 2020

Stefanie Igelbrink

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18 January 2020

Ute Hecker

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18 January 2020

Sierk Haenisch

7

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18 January 2020

Bernd Terhaag

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18 January 2020

Werner Siegmund

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18 January 2020

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1 April 2006

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18 January 2020

British Journal of Clinical Pharmacology

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18 January 2020

61

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18 January 2020

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18 January 2020

440-450

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18 January 2020

Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885036

27 July 2018

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885036

27 July 2018

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) and genetic variability (single nucleotide polymorphisms) in a hepatic drug uptake transporter: what's it all about?

1 reference

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27 July 2018

CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885036

27 July 2018

Stereoselective disposition of talinolol in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885036

27 July 2018

Drug interactions of the statins and consequences for drug selection.

1 reference

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27 July 2018

Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885036

27 July 2018

HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885036

27 July 2018

HMG-CoA reductase inhibitors and P-glycoprotein modulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885036

27 July 2018

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) induce hepatic expression of the phospholipid translocase mdr2 in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885036

27 July 2018

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885036

27 July 2018

P-glycoprotein transporters and the gastrointestinal tract: evaluation of the potential in vivo relevance of in vitro data employing talinolol as model compound

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885036

27 July 2018

Clinical pharmacokinetics and practical applications of simvastatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885036

27 July 2018

The biliary elimination of the selective beta-receptor blocking drug talinolol in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885036

27 July 2018

Disposition and bioavailability of the beta 1-adrenoceptor antagonist talinolol in man.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2125.2006.02599.X

21 January 2018

Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: concentration- and dose-dependent absorption in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1111/J.1365-2125.2006.02599.X

21 January 2018

Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil

1 reference

https://api.crossref.org/works/10.1111/J.1365-2125.2006.02599.X

21 January 2018

Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2125.2006.02599.X

21 January 2018

Effect of levothyroxine administration on intestinal P-glycoprotein expression: consequences for drug disposition.

1 reference

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21 January 2018

P-glycoprotein and surfactants: effect on intestinal talinolol absorption

1 reference

https://api.crossref.org/works/10.1111/J.1365-2125.2006.02599.X

21 January 2018

A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters

1 reference

https://api.crossref.org/works/10.1111/J.1365-2125.2006.02599.X

21 January 2018

Simvastatin and lovastatin, but not pravastatin, interact with MDR1.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2125.2006.02599.X

21 January 2018

The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2125.2006.02599.X

21 January 2018

Identification of functionally variant MDR1 alleles among European Americans and African Americans

1 reference

https://api.crossref.org/works/10.1111/J.1365-2125.2006.02599.X

21 January 2018

Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics

1 reference

https://api.crossref.org/works/10.1111/J.1365-2125.2006.02599.X

21 January 2018

Pharmacokinetics and bioequivalence evaluation of two simvastatin 40 mg tablets (Simvast and Zocor) in healthy human volunteers

1 reference

https://api.crossref.org/works/10.1111/J.1365-2125.2006.02599.X

21 January 2018

The talinolol double-peak phenomenon is likely caused by presystemic processing after uptake from gut lumen

1 reference

https://api.crossref.org/works/10.1111/J.1365-2125.2006.02599.X

21 January 2018

Grapefruit juice ingestion significantly reduces talinolol bioavailability

1 reference

https://api.crossref.org/works/10.1111/J.1365-2125.2006.02599.X

21 January 2018

P-glycoprotein inhibitor erythromycin increases oral bioavailability of talinolol in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16542205

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral bioavailability of digoxin is enhanced by talinolol: evidence for involvement of intestinal P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16542205

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma concentrations of active simvastatin acid are increased by gemfibrozil

1 reference

https://pubmed.ncbi.nlm.nih.gov/16542205

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: a new type of drug/drug interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16542205

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rifampin greatly reduces plasma simvastatin and simvastatin acid concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/16542205

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct demonstration of small intestinal secretion and site-dependent absorption of the beta-blocker talinolol in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16542205

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unexpected effect of verapamil on oral bioavailability of the beta-blocker talinolol in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16542205

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2125.2006.02599.X

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16542205 AND SRC:MED&resulttype=core&format=json

18 January 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16542205 AND SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

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Europe PubMed Central

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18 January 2020

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