Antioxidants in the canine model of human aging (Q35795151)

10 August 2017

title

Antioxidants in the canine model of human aging (English)

1 reference

10 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22005070

15 December 2024

author name string

Elizabeth Head

series ordinal

2

1 reference

10 August 2017

Amy L. S. Dowling

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22005070

15 December 2024

language of work or name

English

0 references

publication date

8 October 2011

1 reference

full work available at URL

10 August 2017

https://doi.org/10.1016/j.bbadis.2011.09.020

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22005070

https://europepmc.org/articles/PMC3291812

15 December 2024

file format

HyperText Markup Language

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22005070

https://europepmc.org/articles/PMC3291812?pdf=render

15 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22005070

https://api.elsevier.com/content/article/PII:S0925443911002249?httpAccept=text/xml

15 December 2024

1 reference

Crossref

https://api.crossref.org/works/10.1016/J.BBADIS.2011.09.020

https://api.elsevier.com/content/article/PII:S0925443911002249?httpAccept=text/plain

15 December 2024

1 reference

Crossref

https://api.crossref.org/works/10.1016/J.BBADIS.2011.09.020

Biochimica et Biophysica Acta

15 December 2024

published in

1 reference

10 August 2017

volume

1822

1 reference

10 August 2017

issue

5

1 reference

10 August 2017

page(s)

685-689

1 reference

A Potential Design Flaw of Randomized Trials of Vitamin Supplements

10 August 2017

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Analysis of postmortem ventricular cerebrospinal fluid from patients with and without dementia indicates association of vitamin E with neuritic plaques and specific measures of cognitive performance

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Cellular Stress Responses, Mitostress and Carnitine Insufficiencies as Critical Determinants in Aging and Neurodegenerative Disorders: Role of Hormesis and Vitagenes

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BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog

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Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles

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The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches.

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Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows

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Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine

12 July 2018

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Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons

12 July 2018

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12 July 2018

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Alpha-lipoic acid as a new treatment option for Alzheimer's disease--a 48 months follow-up analysis.

12 July 2018

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Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease

12 July 2018

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Oxidatively modified RNA in mild cognitive impairment

12 July 2018

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Mitochondria in aging and Alzheimer's disease.

12 July 2018

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Region specific neuron loss in the aged canine hippocampus is reduced by enrichment

12 July 2018

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Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease

12 July 2018

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Effects of antioxidants on the aging inner ear

12 July 2018

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The beneficial effects of fruit polyphenols on brain aging

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication

12 July 2018

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Free radicals and brain aging

12 July 2018

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Proteomics: a new approach to investigate oxidative stress in Alzheimer's disease brain

12 July 2018

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Effects of acetyl-L-carnitine in Alzheimer's disease patients unresponsive to acetylcholinesterase inhibitors

12 July 2018

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Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy

12 July 2018

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Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction

12 July 2018

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Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases

12 July 2018

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12 July 2018

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Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.

12 July 2018

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Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites

12 July 2018

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Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease

12 July 2018

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Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid

12 July 2018

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Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins

12 July 2018

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Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease

12 July 2018

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Oxidative stress protection and vulnerability in aging: putative nutritional implications for intervention

12 July 2018

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Stress, aging, and brain oxidative damage

12 July 2018

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Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication

12 July 2018

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Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches

12 July 2018

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The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach

12 July 2018

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Mitochondrial Dysfunction in the Senescence Accelerated Mouse (SAM)

12 July 2018

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Oxidative Stress and Mitochondrial DNA Mutations in Human Aging

12 July 2018

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Oxidative damage during aging targets mitochondrial aconitase

12 July 2018

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Protein Oxidation in Aging, Disease, and Oxidative Stress

12 July 2018

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Reactive oxygen-mediated protein oxidation in aging and disease

12 July 2018

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Oxidative stress hypothesis in Alzheimer's disease

12 July 2018

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Oxidants, antioxidants, and the degenerative diseases of aging

12 July 2018

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Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.

12 July 2018

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Oxidative damage and mitochondrial decay in aging

12 July 2018

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Mitochondrial role in cell aging

12 July 2018

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Study of the efficacy and tolerability of L-acetylcarnitine therapy in the senile brain

12 July 2018

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Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia.

12 July 2018

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Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease

12 July 2018

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Mitochondrial genetics: a paradigm for aging and degenerative diseases?

12 July 2018

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Oxidants are a major contributor to aging

12 July 2018

1 reference

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Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease

12 July 2018

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Protein oxidation and aging

12 July 2018

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Differences in lipid peroxidation and Cu,Zn-superoxide dismutase in the hippocampal CA1 region between adult and aged dogs

12 July 2018

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Enhanced spatial ability in aged dogs following dietary and behavioural enrichment

25 September 2018

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A randomized trial of vitamin E supplementation and cognitive function in women

25 September 2018

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Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer's disease

25 September 2018

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Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E.

25 September 2018

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Supplemental use of antioxidant vitamins and subsequent risk of cognitive decline and dementia

25 September 2018

1 reference

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Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs.

25 September 2018

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Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study.

25 September 2018

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Age-dependent alterations in mitochondrial enzymes in cortex, striatum and hippocampus of rat brain -- potential role of L-Carnitine

25 September 2018

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Histochemical accumulation of oxidative damage products is associated with Alzheimer-like pathology in the canine

25 September 2018

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Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs

25 September 2018

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Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study

25 September 2018

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The role of free radicals in canine counterpart of senile dementia of the Alzheimer type

25 September 2018

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Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease

25 September 2018

1 reference

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Antioxidant vitamin intake and risk of Alzheimer disease

25 September 2018

1 reference

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Dietary enrichment counteracts age-associated cognitive dysfunction in canines

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Oxidative damage increases with age in a canine model of human brain aging

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Vitamin E and cognitive decline in older persons

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Dietary intake of antioxidants and risk of Alzheimer disease

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Effect of vitamin and trace-element supplementation on cognitive function in elderly subjects.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Alpha-lipoic acid as a new treatment option for Alzheimer [corrected] type dementia

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Mitochondrial abnormalities in Alzheimer's disease.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Immunohistochemical investigation of the brain of aged dogs. I. Detection of neurofibrillary tangles and of 4-hydroxynonenal protein, an oxidative damage product, in senile plaques

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Protein oxidation in the brain in Alzheimer's disease

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

A 1-year controlled trial of acetyl-l-carnitine in early-onset AD.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Association of vitamin E and C supplement use with cognitive function and dementia in elderly men.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Oxidative damage in the senescence-accelerated mouse.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Abnormalities of mitochondrial enzymes in Alzheimer disease

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Increased F2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Increased nuclear DNA oxidation in the brain in Alzheimer's disease

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Acetyl L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

The CERAD Neuropathology Protocol and Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease: A Commentary

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Widespread peroxynitrite-mediated damage in Alzheimer's disease

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's disease

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease

23 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

23 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291812

Mitochondrial respiratory chain activity in the human brain as a function of age

6 December 2018

1 reference

12 December 2020

Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity

1 reference

12 December 2020

Studies on lipid peroxidation and protein oxidation in the aging brain

1 reference

12 December 2020

Oxidative stress and age-related neuronal deficits

1 reference

12 December 2020

Insights into the disappointing clinical trials of antioxidants in neurodegenerative diseases

1 reference

12 December 2020

Long-term acetyl-L-carnitine treatment in Alzheimer's disease

series ordinal

71

1 reference

Crossref

https://api.crossref.org/works/10.1016/J.BBADIS.2011.09.020

15 December 2024

Identifiers

1 reference

10 August 2017

1 reference

10 August 2017

1 reference