Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans (Q35778031)

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29 December 2019

title

Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans (English)

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29 December 2019

0 references

8

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David A Harris

10

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29 December 2019

author name string

Shaoman Yin

1

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29 December 2019

Nancy Pham

2

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29 December 2019

Shuiliang Yu

3

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29 December 2019

Chaoyang Li

4

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29 December 2019

Poki Wong

5

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29 December 2019

Binggong Chang

6

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29 December 2019

Shin-Chung Kang

7

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29 December 2019

Po Tien

9

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29 December 2019

Man-Sun Sy

11

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29 December 2019

language of work or name

English

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publication date

24 April 2007

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

29 December 2019

published in

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29 December 2019

volume

104

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29 December 2019

issue

18

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29 December 2019

page(s)

7546-7551

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Aggregation of prion protein with insertion mutations is proportional to the number of inserts

29 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

An aggregation-specific enzyme-linked immunosorbent assay: detection of conformational differences between recombinant PrP protein dimers and PrP(Sc) aggregates

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Heparan sulfate is a cellular receptor for purified infectious prions.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Screening of 145 anti-PrP monoclonal antibodies for their capacity to inhibit PrPSc replication in infected cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Pathogenic mutations located in the hydrophobic core of the prion protein interfere with folding and attachment of the glycosylphosphatidylinositol anchor.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Octapeptide repeat insertions in the prion protein gene and early onset dementia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

On-column purification and refolding of recombinant bovine prion protein: using its octarepeat sequences as a natural affinity tag.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

The Octapeptide Repeats in Mammalian Prion Protein Constitute a pH-dependent Folding and Aggregation Site

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Prion protein conversions: insight into mechanisms, TSE transmission barriers and strains

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Molecular distinction between pathogenic and infectious properties of the prion protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Mutations of the prion protein gene phenotypic spectrum

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Cell-surface prion protein interacts with glycosaminoglycans

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Shattuck lecture--neurodegenerative diseases and prions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Prion diseases of humans and animals: their causes and molecular basis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Sulfated glycans and elevated temperature stimulate PrP(Sc)-dependent cell-free formation of protease-resistant prion protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Molecular dynamics simulation of human prion protein including both N-linked oligosaccharides and the GPI anchor.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Solution structure of the E200K variant of human prion protein. Implications for the mechanism of pathogenesis in familial prion diseases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

NMR solution structure of the human prion protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Familial prion disease mutation alters the secondary structure of recombinant mouse prion protein: implications for the mechanism of prion formation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Influence of amino acid substitutions related to inherited human prion diseases on the thermodynamic stability of the cellular prion protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Eight prion strains have PrP(Sc) molecules with different conformations

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Prion protein NMR structure and familial human spongiform encephalopathies

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Prion protein expression in different species: analysis with a panel of new mAbs

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Two mutant prion proteins expressed in cultured cells acquire biochemical properties reminiscent of the scrapie isoform.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Mutant and infectious prion proteins display common biochemical properties in cultured cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Scrapie-associated PrP accumulation and its inhibition: revisiting the amyloid-glycosaminoglycan connection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Novel proteinaceous infectious particles cause scrapie

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Self-replication and scrapie

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Sulfated glycosaminoglycans in amyloid plaques of prion diseases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Inherited human prion diseases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Molecular biology of prion diseases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Familial mutations and the thermodynamic stability of the recombinant human prion protein

12 July 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0610827104

Identification of the heparan sulfate binding sites in the cellular prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0610827104

Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0610827104

Cellular heparan sulfate participates in the metabolism of prions

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0610827104

PrPSc incorporation to cells requires endogenous glycosaminoglycan expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0610827104

Influence of the N-terminal domain on the aggregation properties of the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0610827104

Disease-associated F198S mutation increases the propensity of the recombinant prion protein for conformational conversion to scrapie-like form

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0610827104

Identification of distinct N-terminal truncated forms of prion protein in different Creutzfeldt-Jakob disease subtypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0610827104

N-terminal truncation of prion protein affects both formation and conformation of abnormal protease-resistant prion protein generated in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0610827104

Flexible N-terminal region of prion protein influences conformation of protease-resistant prion protein isoforms associated with cross-species scrapie infection in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0610827104

Structures of prion proteins and conformational models for prion diseases

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1863438

Prion proteins with insertion mutations have altered N-terminal conformation and increased ligand binding activity and are more susceptible to oxidative attack

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17456603

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Prion Protein Interaction with Glycosaminoglycan Occurs with the Formation of Oligomeric Complexes Stabilized by Cu(II) Bridges

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17456603

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of an epitope in the C terminus of normal prion protein whose expression is modulated by binding events in the N terminus

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17456603

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0610827104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17456603 AND SRC:MED&resulttype=core&format=json

29 December 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17456603 AND SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

17456603

1 reference