Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib (Q35774432)

10 August 2017

title

Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib (English)

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10 August 2017

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Tessa L Holyoake

7

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author name string

Ling Li

1

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10 August 2017

Lisheng Wang

2

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10 August 2017

Liang Li

3

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10 August 2017

Zhiqiang Wang

4

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10 August 2017

Yinwei Ho

5

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10 August 2017

Tinisha McDonald

6

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10 August 2017

WenYong Chen

8

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10 August 2017

Ravi Bhatia

9

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10 August 2017

publication date

1 February 2012

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10 August 2017

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10 August 2017

volume

21

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10 August 2017

issue

2

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10 August 2017

page(s)

266-281

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Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment

10 August 2017

cites work

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Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

12 July 2018

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SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse

12 July 2018

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Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial

12 July 2018

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Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate

12 July 2018

1 reference

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MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1

12 July 2018

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The critical role of the class III histone deacetylase SIRT1 in cancer

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How does SIRT1 affect metabolism, senescence and cancer?

12 July 2018

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p53 regulates hematopoietic stem cell quiescence.

12 July 2018

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c-Abl phosphorylates Hdmx and regulates its interaction with p53.

12 July 2018

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Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis

12 July 2018

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Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice

12 July 2018

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Acetylation is indispensable for p53 activation

12 July 2018

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Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.

12 July 2018

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The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

12 July 2018

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SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization

12 July 2018

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SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity

12 July 2018

1 reference

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p53 in health and disease

12 July 2018

1 reference

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Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia

12 July 2018

1 reference

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Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage

12 July 2018

1 reference

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Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

12 July 2018

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MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

12 July 2018

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Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells

12 July 2018

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Calorie restriction, SIRT1 and metabolism: understanding longevity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285436

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285436

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285436

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

12 July 2018

1 reference

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BCR/ABL activates mdm2 mRNA translation via the La antigen

12 July 2018

1 reference

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12 July 2018

Why is p53 acetylated?

1 reference

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Negative control of p53 by Sir2alpha promotes cell survival under stress

12 July 2018

1 reference

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12 July 2018

Chronic myeloid leukemia

1 reference

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Structure and function of p53 in normal cells and their aberrations in cancer cells: projection on the hematologic cell lineages

12 July 2018

1 reference

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p53 in chronic myeloid leukemia cell lines

12 July 2018

1 reference

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Nonproliferating CML CD34 progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285436

SirT1 fails to affect p53-mediated biological functions

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22340598

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22340598

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

p53 stabilization induces apoptosis in chronic myeloid leukemia blast crisis cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22340598

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCR.2011.12.020

1 reference

10 August 2017

1 reference

10 August 2017

1 reference