Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers (Q35770186)

10 August 2017

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title

Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers (English)

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10 August 2017

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Gould TD

1

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10 August 2017

Quiroz JA

2

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10 August 2017

Singh J

3

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10 August 2017

Zarate CA

4

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10 August 2017

Manji HK

5

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10 August 2017

language of work or name

English

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publication date

1 August 2004

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10 August 2017

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10 August 2017

volume

9

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10 August 2017

issue

8

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10 August 2017

page(s)

734-755

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Social and economic burden of mood disorders

10 August 2017

cites work

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The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3.

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Preclinical models: status of basic research in depression

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Finding the Intracellular Signaling Pathways Affected by Mood Disorder Treatments

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Lithium inhibits glycogen synthase kinase-3 by competition for magnesium.

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Mood stabilizer psychopharmacology

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Definition of a metal-dependent/Li( )-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure

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Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate

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Enzyme-bound intermediates in the conversion of glucose 1-phosphate to glucose 6-phosphate by phosphoglucomutase. Phosphorus NMR studies

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The binding of lithium and of anionic metabolites to phosphoglucomutase

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A molecular mechanism for the effect of lithium on development

21 January 2018

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Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

21 January 2018

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Lithium and valproic acid: parallels and contrasts in diverse signaling contexts

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The promise and perils of Wnt signaling through beta-catenin.

21 January 2018

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21 January 2018

The renaissance of GSK3

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Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

21 January 2018

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3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).

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Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418

21 January 2018

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Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle

21 January 2018

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First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease

21 January 2018

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Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3.

21 January 2018

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Inositol phosphate biochemistry

21 January 2018

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Neural and developmental actions of lithium: a unifying hypothesis

21 January 2018

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Inositol monophosphatase inhibitors--lithium mimetics?

21 January 2018

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In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330.

21 January 2018

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Lithium and myo-inositol homeostasis

21 January 2018

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Biosynthesis of myo-inositol in rat mammary gland. Isolation and properties of the enzymes.

21 January 2018

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The dephosphorylation of inositol 1,4-bisphosphate to inositol in liver and brain involves two distinct Li -sensitive enzymes and proceeds via inositol 4-phosphate

21 January 2018

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Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

21 January 2018

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Lithium and the phosphoinositide cycle: an example of uncompetitive inhibition and its pharmacological consequences

21 January 2018

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Reduced Brain Inositol in Lithium-treated Rats

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

Mechanism of inositol monophosphatase, the putative target of lithium therapy

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

Structure of inositol monophosphatase, the putative target of lithium therapy

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3.

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100.

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

The Wnt signaling pathway in bipolar disorder

21 January 2018

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Endophenotypes in bipolar disorder

21 January 2018

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Mood stabilizers, glycogen synthase kinase-3beta and cell survival

21 January 2018

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Lithium at 50: have the neuroprotective effects of this unique cation been overlooked?

21 January 2018

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Neuroprotective effects of lithium in cultured cells and animal models of diseases.

21 January 2018

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Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus.

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain

21 January 2018

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Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade

21 January 2018

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The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes

21 January 2018

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GSK3beta signalling: casting a wide net in Alzheimer's disease

21 January 2018

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Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease

21 January 2018

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Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3-kinase--dependent pathway is cardioprotective

21 January 2018

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Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

Antidepressant-like properties of zinc in rodent forced swim test

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in rats

21 January 2018

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Effects of trimebutine maleate on delayed rectifier K currents in guinea-pig ventricular myocytes

21 January 2018

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Stimulatory effect of paeoniflorin on the release of noradrenaline from ileal synaptosomes of guinea-pig in-vitro

21 January 2018

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Crystallographic evidence for the action of potassium, thallium, and lithium ions on fructose-1,6-bisphosphatase

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

Kinetics and mechanisms of activation and inhibition of porcine liver fructose-1,6-bisphosphatase by monovalent cations.

21 January 2018

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3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site

21 January 2018

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A novel mammalian lithium-sensitive enzyme with a dual enzymatic activity, 3'-phosphoadenosine 5'-phosphate phosphatase and inositol-polyphosphate 1-phosphatase

21 January 2018

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A novel target of lithium therapy

21 January 2018

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Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy

21 January 2018

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Possible role of 3'(2')-phosphoadenosine-5'-phosphate phosphatase in the etiology and therapy of bipolar disorder

21 January 2018

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Mechanisms of action of valproate: a commentatory

21 January 2018

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Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

21 January 2018

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Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

21 January 2018

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Incorporation of [3H]valproic acid into lipids in GT1-7 neurons

21 January 2018

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Antiepileptic drug mechanisms of action

21 January 2018

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Di-n-propylacetate and GABA degradation. Preferential inhibition of succinic semialdehyde dehydrogenase and indirect inhibition of GABA-transaminase

21 January 2018

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Effects of anticonvulsant drugs on the cerebral enzymes metabolizing GABA.

21 January 2018

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Effects of the anticonvulsant sodium valproate on gamma-aminobutyrate and aldehyde metabolism in ox brain

21 January 2018

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Effect of valproate on human cerebral glucose metabolism

21 January 2018

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Effects of DI-n-propylacetate, and anticonvulsive compound, on GABA metabolism

21 January 2018

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Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino acids in the brain

21 January 2018

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Differential effect of gamma-vinyl GABA and valproate on GABA-transaminase from cultured neurones and astrocytes

21 January 2018

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Valproate and GABAergic System Effects

21 January 2018

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An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability

21 January 2018

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Valproate administration to mice increases histone acetylation and 5-lipoxygenase content in the hippocampus

21 January 2018

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Histone deacetylase is a target of valproic acid-mediated cellular differentiation

21 January 2018

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Histone deacetylases and cancer: causes and therapies

21 January 2018

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Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

21 January 2018

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Phenytoin and carbamazepine: potential- and frequency-dependent block of Na currents in mammalian myelinated nerve fibers

21 January 2018

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Modulated anticonvulsant block of sodium channels in nerve and muscle

21 January 2018

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A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder

21 January 2018

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Prophylactic effect of phenytoin in bipolar disorder: a controlled study

21 January 2018

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Cyclic AMP Accumulation in Cerebral Cortical Slices: Effect of Carbamazepine, Phenobarbital, and Phenytoin

21 January 2018

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Interactions of the Anticonvulsant Carbamazepine with Adenosine Receptors. 2. Pharmacological Studies

21 January 2018

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Specific and potent interactions of carbamazepine with brain adenosine receptors

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

A purinergic component in the anticonvulsant action of carbamazepine?

21 January 2018

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Interaction of Anticonvulsant Drugs with Adenosine Receptors in the Central Nervous System

21 January 2018

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Carbamazepine distinguishes between adenosine receptors that mediate different second messenger responses

21 January 2018

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Chronic carbamazepine treatment increases brain adenosine receptors

21 January 2018

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Carbamazepine inhibits the potentiation by adenosine analogues of agonist induced inositolphosphate formation in hippocampal astrocyte cultures

21 January 2018

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Species differences in brain adenosine A1 receptor pharmacology revealed by use of xanthine and pyrazolopyridine based antagonists

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

Interactions of antiepileptic drugs on adenylate cyclase and phosphodiesterases in rat and mouse cerebrum

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

Anticonvulsant Drug Actions on In Vitro and In Vivo Levels of Cyclic AMP in the Mouse Brain

21 January 2018

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Inhibitory effects of anticonvulsant drugs on cyclic nucleotide accumulation in brain

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024.

21 January 2018

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Dibutyryl cyclic AMP has epileptogenic potential in the hippocampus of freely behaving rats: a combined EEG-intracerebral microdialysis study

21 January 2018

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Synaptic plasticity and mood disorders

21 January 2018

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Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

Lithium treatment alters brain concentrations of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in a rat model of depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Carbamazepine and electroconvulsive shock attenuate beta-adrenoceptor and muscarinic cholinoceptor coupling to G proteins in rat cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

A bimodal model of the mechanism of action of lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Lithium, But Not Carbamazepine, Potentiates Hyperactivity Induced by Intra-accumbens Cholera Toxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Effects of valproic acid on beta-adrenergic receptors, G-proteins, and adenylyl cyclase in rat C6 glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Changes in lymphocyte beta-adrenergic receptors in depression and mania

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

The cyclic AMP second messenger system in man: the effects of heredity, hormones, drugs, aluminum, age and disease on signal amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

CNS signal transduction in the pathophysiology and pharmacotherapy of affective disorders and schizophrenia

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

The interactions of adenylate cyclases with P-site inhibitors

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

Isoform-specific regulation of adenylyl cyclase: a potential target in future pharmacotherapy

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

CaM-kinases: modulators of synaptic plasticity

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

Ziskind-Somerfeld Research Award. Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

The high affinity inositol transport system--implications for the pathophysiology and treatment of bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Inhibition of the high affinity myo-inositol transport system: a common mechanism of action of antibipolar drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

A common mechanism of action for three mood-stabilizing drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Modulation of protein kinase C isozymes and substrates by lithium: the role of myo-inositol

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.MP.4001518

Chronic lithium administration alters a prominent PKC substrate in rat hippocampus

21 January 2018

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Sensitization, kindling, and carbamazepine: an update on their implications for the course of affective illness

21 January 2018

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Kindled amygdaloid seizures in rats cause immediate and transient increase in protein kinase C activity followed by transient suppression of the activity

21 January 2018

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Amygdala kindling‐induced seizures selectively impair spatial memory. 1. Behavioral characteristics and effects on hippocampal neuronal protein kinase C isoforms

21 January 2018

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Amygdala kindling alters protein kinase C activity in dentate gyrus

21 January 2018

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Long-term increase in protein kinase C-gamma and muscarinic acetylcholine receptor expression in the cerebral cortex of amygdala-kindled rats--a quantitative immunocytochemical study

21 January 2018

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Protein kinase C and dopamine transport--2. Effects of amphetamine in vitro

21 January 2018

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Protein kinase C and dopamine transport--1. Effects of amphetamine in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Amphetamine increases the phosphorylation of neuromodulin and synapsin I in rat striatal synaptosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Injection of the protein kinase inhibitor H7 into the A10 dopamine region blocks the acute responses to cocaine: behavioral and in vivo microdialysis studies

21 January 2018

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Mania in association with hydrocortisone replacement for Addison's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Diagnostic categorization of psychiatric disturbance in Cushing's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Administration of dexamethasone up-regulates protein kinase C activity and the expression of gamma and epsilon protein kinase C isozymes in the rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Expression and regulation of the human dopamine transporter in a neuronal cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Inhibition of protein kinase C mediated signal transduction by tamoxifen. Importance for antitumour activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Potential new medical therapies for diabetic retinopathy: protein kinase C inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

The potential role of PKC beta in diabetic retinopathy and macular edema

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Inhibition of protein kinase C--do we, can we, and should we?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Selective chronic stress-induced in vivo ERK1/2 hyperphosphorylation in medial prefrontocortical dendrites: implications for stress-related cortical pathology?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Social stress exacerbates stroke outcome by suppressing Bcl-2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

PKC, MAP kinases and the bcl-2 family of proteins as long-term targets for mood stabilizers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Histopathology of the prefrontal cortex in major depression: what does it tell us about dysfunctional monoaminergic circuits?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Support of retinal ganglion cell survival and axon regeneration by lithium through a Bcl-2-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers: implications for the pathophysiology and treatment of manic-depressive illness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Subgenual prefrontal cortex abnormalities in mood disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Low glial numbers in the amygdala in major depressive disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

N-acetylaspartate in neuropsychiatric disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Increased gray matter volume in lithium-treated bipolar disorder patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Chronic treatment with lithium, but not sodium valproate, increases cortical N-acetyl-aspartate concentrations in euthymic bipolar patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Neurotrophic effects of electroconvulsive therapy: a proton magnetic resonance study of the left amygdalar region in patients with treatment-resistant depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Apoptosis modulators in the therapy of neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Preliminary randomized, double-blind, placebo-controlled trial of pramipexole added to mood stabilizers for treatment-resistant bipolar depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

In vivo fatty acid incorporation into brain phosholipids in relation to plasma availability, signal transduction and membrane remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Chronic valproate treatment decreases the in vivo turnover of arachidonic acid in brain phospholipids: a possible common effect of mood stabilizers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Lithium decreases turnover of arachidonate in several brain phospholipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Do lithium and anticonvulsants target the brain arachidonic acid cascade in bipolar disorder?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Chronic lithium treatment decreases brain phospholipase A2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

85 kDa cytosolic phospholipase A2 is a target for chronic lithium in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Chronic lithium downregulates cyclooxygenase-2 activity and prostaglandin E(2) concentration in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Cyclooxygenase inhibitor modulation of dopamine-related behaviours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Evidence for the involvement of cyclooxygenase activity in the development of cocaine sensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Induction of cyclooxygenase-2 accounts for restraint stress-induced oxidative status in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Intravenous Fosphenytoin in Acute Mania

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

Impact of bipolar disorder on a U.S. community sample.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Mood disorders and medical illness: a major public health problem

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Comparison of fluorescence, (31)P NMR, and (7)Li NMR spectroscopic methods for investigating Li( )/Mg(2 ) competition for biomolecules

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Lithium-induced respecification of pattern in Xenopus laevis embryos

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Inhibitors of glycogen synthase kinase-3: future therapy for unmet medical needs?

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Effect of berberine on proliferation, cell cycle and apoptosis in HeLa and L1210 cells

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

The operation of the γ-aminobutyrate bypath of the tricarboxylic acid cycle in brain tissue in vitro

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Effect of valproate on cerebral metabolism and blood flow: an 18F-2-deoxyglucose and 15O water positron emission tomography study

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group.

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Phenytoin as an antimanic anticonvulsant: a controlled study

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Prospective role for adenosine and adenosinergic systems in psychiatric disorders.

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Persistent upregulation of brain adenosine receptors in response to chronic carbamazepine treatment.

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Chronic carbamazepine down-regulates adenosine A2 receptors: studies with the putative selective adenosine antagonists PD115,199 and PD116,948

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Attenuation of cyclic AMP production by carbamazepine.

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Differential effect of lithium on fos protooncogene expression mediated by receptor and postreceptor activators of protein kinase C and cyclic adenosine monophosphate: Model for its antimanic action

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

The role of the extracellular signal-regulated kinase signaling pathway in mood modulation.

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Lithium decreases membrane-associated protein kinase C in hippocampus: selectivity for the alpha isozyme

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Selective Inhibition of the Expression of Signal Transduction Proteins by Lithium in Nerve Growth Factor‐Differentiated PC12 Cells

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Chronic lithium-induced down-regulation of MARCKS in immortalized hippocampal cells: potentiation by muscarinic receptor activation

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Chronic sodium valproate selectively decreases protein kinase C alpha and epsilon in vitro.

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Differential changes in the activities of multiple protein kinase C subspecies in the hippocampal-kindled rat

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Long-lasting increase in protein kinase C activity in the hippocampus of amygdala-kindled rat

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Isozyme specific changes in the expression of protein kinase C isozyme (alpha-zeta) genes in the hippocampus of rats induced by kindling epileptogenesis

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Phosphorylation of neuromodulin in rat striatum after acute and repeated, intermittent amphetamine

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Intra-A10 injection of H7 blocks the development of sensitization to cocaine.

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Granisetron and ondansetron: effects on the ileal brake mechanism in the rat

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

A preliminary investigation of a protein kinase C inhibitor in the treatment of acute mania

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Anticonvulsants attenuate amyloid beta-peptide neurotoxicity, Ca2 deregulation, and cytoskeletal pathology

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2's neurotrophic effects?

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Lithium-induced increase in human brain grey matter

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Increase of bcl-2 protein in neuronal dendritic processes of cerebral cortex and hippocampus by the antiparkinsonian drugs, talipexole and pramipexole

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Valproic acid down‐regulates the conversion of arachidonic acid to eicosanoids via cyclooxygenase‐1 and ‐2 in rat brain

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4001518

7 January 2021

Identifiers

DOI

10.1038/SJ.MP.4001518

1 reference

10 August 2017

1 reference