Mechanistic diversity of cytokine receptor signaling across cell membranes (Q35764259)

10 August 2017

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title

Mechanistic diversity of cytokine receptor signaling across cell membranes (English)

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10 August 2017

Robert M Stroud

1

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10 August 2017

James A Wells

series ordinal

2

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10 August 2017

publication date

28 April 2004

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Science's STKE : signal transduction knowledge environment

10 August 2017

published in

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10 August 2017

volume

2004

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10 August 2017

issue

231

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10 August 2017

page(s)

re7

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G-protein coupled receptors: conformations and states

10 August 2017

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Structural basis for FGF receptor dimerization and activation

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Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule

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A hot spot of binding energy in a hormone-receptor interface

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The molecular mechanism of erythropoietin action

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Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism

21 January 2018

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Homodimerization and constitutive activation of the erythropoietin receptor

21 January 2018

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Activation and inhibition of erythropoietin receptor function: role of receptor dimerization

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A constitutively activated erythropoietin receptor stimulates proliferation and contributes to transformation of multipotent, committed nonerythroid and erythroid progenitor cells

21 January 2018

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Small peptides as potent mimetics of the protein hormone erythropoietin

21 January 2018

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Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A

21 January 2018

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An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation

21 January 2018

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Growth hormone binding affinity for its receptor surpasses the requirements for cellular activity

21 January 2018

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Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5.

21 January 2018

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The prolactin receptor and severely truncated erythropoietin receptors support differentiation of erythroid progenitors

21 January 2018

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Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction

21 January 2018

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Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: A fluorescence resonance energy transfer study

21 January 2018

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EGF-induced redistribution of erbB2 on breast tumor cells: flow and image cytometric energy transfer measurements

21 January 2018

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Crystallographic evidence for dimerization of unliganded tumor necrosis factor receptor

21 January 2018

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Structures of the extracellular domain of the type I tumor necrosis factor receptor

21 January 2018

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Discovery of a Novel Thrombopoietin Mimic Agonist Peptide

21 January 2018

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Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine

21 January 2018

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Semirational design of a potent, artificial agonist of fibroblast growth factor receptors

21 January 2018

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Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site

21 January 2018

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Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

21 January 2018

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21 January 2018

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The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes

21 January 2018

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Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface

21 January 2018

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Global and local determinants for the kinetics of interleukin-4/interleukin-4 receptor alpha chain interaction. A biosensor study employing recombinant interleukin-4-binding protein

21 January 2018

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A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor alpha chain

21 January 2018

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Identification of residues critical to the activity of human granulocyte colony-stimulating factor

21 January 2018

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Formation of 1:1 complex of the cytokine receptor homologous region of granulocyte colony-stimulating factor receptor with ligand.

21 January 2018

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Structure of an extracellular gp130 cytokine receptor signaling complex

21 January 2018

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Three-dimensional structure of recombinant human interferon-gamma

21 January 2018

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Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor

21 January 2018

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The IFN gamma receptor: a paradigm for cytokine receptor signaling

21 January 2018

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Conformational Changes in G-CSF/Receptor Complex As Investigated by Isotope-Edited FTIR Spectroscopy

21 January 2018

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Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex

21 January 2018

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Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1.

21 January 2018

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Crystal structure of interleukin 10 reveals an interferon gamma-like fold

21 January 2018

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21 January 2018

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Structure of tumour necrosis factor

21 January 2018

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A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

21 January 2018

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Structural basis for self-association and receptor recognition of human TRAF2

21 January 2018

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Prevention of constitutive TNF receptor 1 signaling by silencer of death domains

21 January 2018

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Modularity in the TNF-receptor family

21 January 2018

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Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs

21 January 2018

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Ligand binding properties of binary complexes of heparin and immunoglobulin-like modules of FGF receptor 2.

21 January 2018

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Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity

21 January 2018

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Structural interactions of fibroblast growth factor receptor with its ligands

21 January 2018

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Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization

21 January 2018

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Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

21 January 2018

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Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

21 January 2018

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Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase

21 January 2018

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Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site

21 January 2018

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Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor

21 January 2018

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Crystal structure of the BMP-2-BRIA ectodomain complex

21 January 2018

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The crystal structure of alpha-bungarotoxin at 2.5 A resolution: relation to solution structure and binding to acetylcholine receptor

21 January 2018

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Structural studies of alpha-bungarotoxin. 3. Corrections in the primary sequence and X-ray structure and characterization of an isotoxic alpha-bungarotoxin.

21 January 2018

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Nicotinic acetylcholine receptor superfamily of ligand-gated ion channels

21 January 2018

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The binding site of acetylcholine receptor as visualized in the X-Ray structure of a complex between alpha-bungarotoxin and a mimotope peptide

21 January 2018

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Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module

21 January 2018

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Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors

21 January 2018

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The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways.

21 January 2018

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Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase

21 January 2018

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Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

21 January 2018

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Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

21 January 2018

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Structure of the extracellular region of HER3 reveals an interdomain tether

21 January 2018

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Mechanism of transmembrane signaling: insulin binding and the insulin receptor

21 January 2018

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Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor

21 January 2018

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The three dimensional structure of the type I insulin-like growth factor receptor

21 January 2018

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The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.

21 January 2018

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Negative cooperativity in the insulin-like growth factor-I receptor and a chimeric IGF-I/insulin receptor

21 January 2018

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Peptides identify the critical hotspots involved in the biological activation of the insulin receptor

21 January 2018

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Crystal structure of the tyrosine kinase domain of the human insulin receptor

21 January 2018

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Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

21 January 2018

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Structural analysis of receptor tyrosine kinases

21 January 2018

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Structure and autoregulation of the insulin-like growth factor 1 receptor kinase

21 January 2018

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Local aggregation of hormone–receptor complexes is required for activation by epidermal growth factor

21 January 2018

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From peptide to non-peptide. 3. Atropisomeric GPIIbIIIa antagonists containing the 3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione nucleus

21 January 2018

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Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits

21 January 2018

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Networks and crosstalk: integrin signalling spreads.

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Integrin modulation by lateral association

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Crystal structure of the extracellular segment of integrin alpha Vbeta3

21 January 2018

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Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

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Effects of ligand-mimetic peptides Arg-Gly-Asp-X (X = Phe, Trp, Ser) on alphaIIbbeta3 integrin conformation and oligomerization

21 January 2018

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Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies

21 January 2018

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21 January 2018

Identifiers

DOI

10.1126/STKE.2312004RE7

1 reference

10 August 2017

1 reference