Zidovudine inhibits thymidine phosphorylation in the isolated perfused rat heart. (Q35758818)

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24 December 2019

title

Zidovudine inhibits thymidine phosphorylation in the isolated perfused rat heart (English)

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24 December 2019

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5

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24 December 2019

author name string

Delia Susan-Resiga

1

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24 December 2019

Alice T Bentley

2

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24 December 2019

Matthew D Lynx

3

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24 December 2019

Darcy D LaClair

4

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24 December 2019

language of work or name

English

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publication date

12 January 2007

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24 December 2019

number of pages

8

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Antimicrobial Agents and Chemotherapy

inferred from page(s)

published in

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24 December 2019

volume

51

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24 December 2019

issue

4

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24 December 2019

page(s)

1142-1149

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Rapid scale-up of antiretroviral therapy at primary care sites in Zambia: feasibility and early outcomes

24 December 2019

cites work

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3'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria

2 October 2017

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Lack of evidence for in vivo transformation of zidovudine triphosphate to stavudine triphosphate in human immunodeficiency virus-infected patients

2 October 2017

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3'-Azido-3'-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity

2 October 2017

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Haematological changes in adults receiving a zidovudine-containing HAART regimen in combination with cotrimoxazole in Côte d'Ivoire

2 October 2017

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Uridine in the prevention and treatment of NRTI-related mitochondrial toxicity

2 October 2017

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DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity.

2 October 2017

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Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity

2 October 2017

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Toxicity of nucleoside analogues used to treat AIDS and the selectivity of the mitochondrial DNA polymerase

2 October 2017

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Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs.

2 October 2017

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2 October 2017

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Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy

2 October 2017

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Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates

2 October 2017

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Physiological concentrations of purines and pyrimidines

2 October 2017

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Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis

2 October 2017

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Metabolic abnormalities in skeletal muscle of patients receiving zidovudine therapy observed by 31P in vivo magnetic resonance spectroscopy

2 October 2017

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Mitochondrial toxicity of antiviral drugs

2 October 2017

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Mitochondrial myopathy caused by long-term zidovudine therapy

2 October 2017

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Zidovudine myopathy: a distinctive disorder associated with mitochondrial dysfunction

2 October 2017

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Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy

2 October 2017

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Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria

2 October 2017

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Is stavudine triphosphate a natural metabolite of zidovudine?

2 October 2017

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mtDNA depletion myopathy: elucidation of the tissue specificity in the mitochondrial thymidine kinase (TK2) deficiency

12 July 2018

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Regulation of thymidine kinase activity in the cell cycle by a labile protein

12 July 2018

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Uridine abrogates the adverse effects of antiretroviral pyrimidine analogues on adipose cell functions.

12 July 2018

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Site specific alterations of adipose tissue mitochondria in 3'-azido-3'-deoxythymidine (AZT)-treated rats: an early stage in lipodystrophy?

25 September 2018

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Uridine pharmacokinetics of mitocnol, a sugar cane extract

25 September 2018

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25 September 2018

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Dilated cardiomyopathy in an adult human immunodeficiency virus type 1-positive patient treated with a zidovudine-containing antiretroviral regimen

25 September 2018

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Significant levels of intracellular stavudine triphosphate are found in HIV-infected zidovudine-treated patients

25 September 2018

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25 September 2018

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Zidovudine-induced mitochondrial disorder with massive liver steatosis, myopathy, lactic acidosis, and mitochondrial DNA depletion.

25 September 2018

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Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells

25 September 2018

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Mitochondrial DNA Depletion and Thymidine Phosphate Pool Dynamics in a Cellular Model of Mitochondrial Neurogastrointestinal Encephalomyopathy

25 September 2018

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12 December 2020

An improved method for isolation of mitochondria in high yields from normal, ischemic, and autolyzed rat hearts

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12 December 2020

Coupling of mitochondrial metabolism and protein synthesis in heart mitochondria

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12 December 2020

Early features of zidovudine-associated myopathy: histopathological findings and clinical correlations

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12 December 2020

Massive hepatic steatosis and lactic acidosis in a patient with AIDS who was receiving zidovudine

1 reference

12 December 2020

Hepatic Morphological alterations induced by zidovudine (ZDV) in an experimental model

1 reference

12 December 2020

The bottleneck in AZT activation

1 reference

12 December 2020

Mitochondria as Cell Targets of AZT (Zidovudine)

1 reference

12 December 2020

HIV infection and zidovudine use in childbearing women

1 reference

12 December 2020

Identifiers

DOI

10.1128/AAC.01227-06

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17220403 AND SRC:MED&resulttype=core&format=json

24 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17220403 AND SRC:MED&resulttype=core&format=json

24 December 2019

PubMed publication ID

17220403

1 reference