Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis. (Q35757295)

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21 January 2020

title

Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis (English)

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21 January 2020

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8

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21 January 2020

author name string

Kimmy G Su

1

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21 January 2020

Costanza Savino

2

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21 January 2020

Gail Marracci

3

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21 January 2020

Priya Chaudhary

4

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21 January 2020

Xiaolin Yu

5

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21 January 2020

Brooke Morris

6

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21 January 2020

Danielle Galipeau

7

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21 January 2020

Michael Forte

9

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21 January 2020

Dennis Bourdette

10

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21 January 2020

language of work or name

English

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publication date

25 January 2012

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European Journal of Neuroscience

21 January 2020

published in

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21 January 2020

volume

35

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21 January 2020

issue

4

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21 January 2020

page(s)

562-571

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Activation of the mitochondrial permeability transition pore modulates Ca2 responses to physiological stimuli in adult neurons

21 January 2020

cites work

1 reference

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The Lifespan-regulator p66Shc in mitochondria: redox enzyme or redox sensor?

2 October 2017

1 reference

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Potential therapeutic benefits of strategies directed to mitochondria.

2 October 2017

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Mitochondria: a therapeutic target in neurodegeneration

2 October 2017

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Abnormal mitochondrial dynamics and neurodegenerative diseases

2 October 2017

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Axonal degeneration in multiple sclerosis: the mitochondrial hypothesis

2 October 2017

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The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice

2 October 2017

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Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

2 October 2017

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Superoxide flashes in single mitochondria

2 October 2017

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Mitochondrial defects in acute multiple sclerosis lesions

2 October 2017

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Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis

2 October 2017

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Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress.

2 October 2017

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The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis

2 October 2017

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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

2 October 2017

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The mitochondrial permeability transition from in vitro artifact to disease target

2 October 2017

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History of modern multiple sclerosis therapy

2 October 2017

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Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

2 October 2017

1 reference

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Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity

2 October 2017

1 reference

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

2 October 2017

1 reference

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Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.

2 October 2017

1 reference

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Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na /Ca2 exchanger

2 October 2017

1 reference

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Alpha lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis

2 October 2017

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2 October 2017

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The p66shc adaptor protein controls oxidative stress response and life span in mammals

2 October 2017

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The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism

2 October 2017

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Permeability of the blood-brain barrier to the immunosuppressive cyclic peptide cyclosporin A.

27 July 2018

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Lipoic acid decreases inflammation and confers neuroprotection in experimental autoimmune optic neuritis

27 July 2018

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Co-localization of sodium channel Nav1.6 and the sodium-calcium exchanger at sites of axonal injury in the spinal cord in EAE.

21 January 2018

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Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients

21 January 2018

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The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.

21 January 2018

1 reference

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Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis

21 January 2018

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The cardioprotective effects elicited by p66(Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury

21 January 2018

1 reference

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Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

25 September 2018

1 reference

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Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22277070

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The mitochondrial apoptosis pathway and p66Shc: A regulatory redox enzyme or an adapter protein snuggling around?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22277070

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Multiple sclerosis: a two-stage disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22277070

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1460-9568.2011.07972.X

1 reference

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21 January 2020

1 reference

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21 January 2020

PubMed publication ID

22277070

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22277070 AND SRC:MED&resulttype=core&format=json