Inhibitors of membranous adenylyl cyclases (Q35740305)

10 August 2017

title

Inhibitors of membranous adenylyl cyclases (English)

1 reference

adenylyl cyclase inhibitors

10 August 2017

main subject

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22100304

18 December 2024

2

Gerald H. Lushington

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22100304

18 December 2024

3

Tung-Chung Mou

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22100304

18 December 2024

4

Andreas Gille

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22100304

18 December 2024

author name string

Roland Seifert

series ordinal

1

1 reference

10 August 2017

Stephen R. Sprang

series ordinal

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22100304

18 December 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22100304

18 December 2024

publication date

17 November 2011

1 reference

full work available at URL

10 August 2017

https://europepmc.org/articles/pmc3273670?pdf=render

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22100304

https://europepmc.org/articles/PMC3273670

18 December 2024

file format

HyperText Markup Language

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22100304

https://europepmc.org/articles/PMC3273670?pdf=render

18 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22100304

https://doi.org/10.1016/j.tips.2011.10.006

18 December 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22100304

https://api.elsevier.com/content/article/PII:S0165614711001933?httpAccept=text/xml

18 December 2024

1 reference

10.1016/J.TIPS.2011.10.006

Crossref

DOI

https://api.crossref.org/works/10.1016/J.TIPS.2011.10.006

https://api.elsevier.com/content/article/PII:S0165614711001933?httpAccept=text/plain

18 December 2024

1 reference

10.1016/J.TIPS.2011.10.006

Crossref

DOI

https://api.crossref.org/works/10.1016/J.TIPS.2011.10.006

Trends in Pharmacological Sciences

18 December 2024

published in

1 reference

10 August 2017

volume

33

1 reference

10 August 2017

issue

2

1 reference

10 August 2017

page(s)

64-78

1 reference

Adenylate Cyclase/cAMP/Protein Kinase A Signaling Pathway Inhibits Endothelin Type A Receptor-Operated Ca2 Entry Mediated via Transient Receptor Potential Canonical 6 Channels

10 August 2017

cites work

1 reference

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Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5'-triphosphates

12 July 2018

1 reference

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Impact of divalent metal ions on regulation of adenylyl cyclase isoforms by forskolin analogs.

12 July 2018

1 reference

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Structure-activity relationships for the interactions of 2'- and 3'-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases

12 July 2018

1 reference

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Structural basis for the high-affinity inhibition of mammalian membranous adenylyl cyclase by 2',3'-o-(N-methylanthraniloyl)-inosine 5'-triphosphate.

12 July 2018

1 reference

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Effect of MANT-nucleotides on L-type calcium currents in murine cardiomyocytes

12 July 2018

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Structural insights into adrenergic receptor function and pharmacology

12 July 2018

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Expression and functional properties of canine, rat, and murine histamine H₄ receptors in Sf9 insect cells.

12 July 2018

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Stimulation of renin secretion by catecholamines is dependent on adenylyl cyclases 5 and 6.

12 July 2018

1 reference

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Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain.

12 July 2018

1 reference

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Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation

12 July 2018

1 reference

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Bis-halogen-anthraniloyl-substituted nucleoside 5'-triphosphates as potent and selective inhibitors of Bordetella pertussis adenylyl cyclase toxin

12 July 2018

1 reference

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Sf9 cells: a versatile model system to investigate the pharmacological properties of G protein-coupled receptors.

12 July 2018

1 reference

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Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.

12 July 2018

1 reference

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Adenylyl cyclase 6 deletion reduces left ventricular hypertrophy, dilation, dysfunction, and fibrosis in pressure-overloaded female mice

12 July 2018

1 reference

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Adenylyl cyclase type 5 protein expression during cardiac development and stress.

12 July 2018

1 reference

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Adenylyl cyclase--A-kinase anchoring protein complexes: the next dimension in cAMP signaling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Differential inhibition of various adenylyl cyclase isoforms and soluble guanylyl cyclase by 2',3'-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5'-triphosphates

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Differential interactions of the catalytic subunits of adenylyl cyclase with forskolin analogs

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Capturing adenylyl cyclases as potential drug targets

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Characterization of mouse heart adenylyl cyclase.

12 July 2018

1 reference

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Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Activation and inhibition of adenylyl cyclase isoforms by forskolin analogs.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Functional adenylyl cyclase inhibition in murine cardiomyocytes by 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-[gamma-thio]triphosphate

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Differential interactions of G-proteins and adenylyl cyclase with nucleoside 5'-triphosphates, nucleoside 5'-[gamma-thio]triphosphates and nucleoside 5'-[beta,gamma-imido]triphosphates.

12 July 2018

1 reference

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Particulate adenylate cyclase plays a key role in human sperm olfactory receptor-mediated chemotaxis

12 July 2018

1 reference

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Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration

12 July 2018

1 reference

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Tyrphostins are inhibitors of guanylyl and adenylyl cyclases

12 July 2018

1 reference

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Isoforms of mammalian adenylyl cyclase: multiplicities of signaling

12 July 2018

1 reference

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Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection

12 July 2018

1 reference

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Pro-nucleotide inhibitors of adenylyl cyclases in intact cells

12 July 2018

1 reference

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Motor dysfunction in type 5 adenylyl cyclase-null mice

12 July 2018

1 reference

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2'(3')-O-(N-methylanthraniloyl)-substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Protein kinases as targets for anticancer agents: from inhibitors to useful drugs

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Molecular basis for P-site inhibition of adenylyl cyclase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

The adenylate cyclase inhibitor MDL-12330A has a non-specific effect on glycine transport in Müller cells from the retina

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

The interactions of adenylate cyclases with P-site inhibitors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9)

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Two amino acid substitutions convert a guanylyl cyclase, RetGC-1, into an adenylyl cyclase.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Regulation of forskolin interactions with type I, II, V, and VI adenylyl cyclases by Gs alpha

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Distinct Characteristics of the Basal Activities of Adenylyl Cyclases 2 and 6

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Vidarabine: a preliminary review of its pharmacological properties and therapeutic use.

12 July 2018

1 reference

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A fluorescent calmodulin that reports the binding of hydrophobic inhibitory ligands

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Binding of [3H]forskolin to rat brain membranes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Effects of RMI 12330A, a new inhibitor of adenylate cyclase on myocardial function and subcellular activity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact human platelets. Evidence for the unidirectional control of platelet function by cyclic AMP

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Mice lacking adenylyl cyclase type 5 (AC5) show increased ethanol consumption and reduced ethanol sensitivity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

l-DOPA-induced dyskinesia in hemiparkinsonian rats is associated with up-regulation of adenylyl cyclase type V/VI and increased GABA release in the substantia nigra reticulata

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Mice lacking adenylyl cyclase-5 cope badly with repeated restraint stress.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

How reliable are G-protein-coupled receptor antibodies?

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Adenylyl cyclase isoform v mediates renin release from juxtaglomerular cells.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Differential expression of adenylyl cyclase subtypes in human cardiovascular system

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Small ligands modulating the activity of mammalian adenylyl cyclases: a novel mode of inhibition by calmidazolium

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Fluorescent nucleotide analogs: synthesis and applications

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Isozyme-dependent sensitivity of adenylyl cyclases to P-site-mediated inhibition by adenine nucleosides and nucleoside 3'-polyphosphates

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

125I-labeled forskolin analogs which discriminate adenylyl cyclase and a glucose transporter: pharmacological characterization and localization of binding sites in rat brain by in vitro receptor autoradiography

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273670

Calmodulin antagonists inhibit activity of myosin light-chain kinase independent of calmodulin

25 September 2018

1 reference

12 December 2020

Actions of vasopressin and isoprenaline on the ionic transport across the isolated frog skin in the presence and the absence of adenyl cyclase inhibitors MDL12330A and SQ22536

1 reference

12 December 2020

MDL 12330A inhibits the non-neuronal adenylyl cyclase from the freshwater snail Planorbarius corneus, but the neuronal enzyme is activated by this compound

1 reference

12 December 2020

Broad specificity of mammalian adenylyl cyclase for interaction with 2',3'-substituted purine- and pyrimidine nucleotide inhibitors

1 reference

12 December 2020

Identification of a forskolin-like molecule in human renal cysts

1 reference

12 December 2020

Adenylyl cyclase isoforms as novel therapeutic targets: an exciting example of excitotoxicity neuroprotection

1 reference

12 December 2020

Pharmacological characterization of adenylyl cyclase isoforms in rabbit kidney membranes

1 reference

12 December 2020

10.1016/J.TIPS.2011.10.006

Identifiers

DOI

1 reference

10 August 2017

1 reference

10 August 2017

1 reference