Molecular regulation of SREBP function: the Insig-SCAP connection and isoform-specific modulation of lipid synthesis (Q35723508)

9 August 2017

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title

Molecular regulation of SREBP function: the Insig-SCAP connection and isoform-specific modulation of lipid synthesis (English)

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9 August 2017

Ruth McPherson

1

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9 August 2017

Andre Gauthier

series ordinal

2

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9 August 2017

publication date

1 February 2004

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Biochemistry and Cell Biology

9 August 2017

published in

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9 August 2017

volume

82

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9 August 2017

issue

1

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9 August 2017

page(s)

201-211

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Adenovirus-mediated overexpression of sterol regulatory element binding protein-1c mimics insulin effects on hepatic gene expression and glucose homeostasis in diabetic mice.

9 August 2017

cites work

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Nutrient regulation of gene expression by the sterol regulatory element binding proteins: increased recruitment of gene-specific coregulatory factors and selective hyperacetylation of histone H3 in vivo

21 January 2018

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Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol

21 January 2018

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Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

21 January 2018

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

21 January 2018

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Functional promoter polymorphism in SREBP cleavage-activating protein (SCAP).

21 January 2018

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Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs

21 January 2018

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Sterol Regulation of 3-Hydroxy-3-Methylglutaryl-coenzyme A Synthase Gene through a Direct Interaction Between Sterol Regulatory Element Binding Protein and the Trimeric CCAAT-binding Factor/Nuclear Factor Y

21 January 2018

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A critical role for cAMP response element-binding protein (CREB) as a Co-activator in sterol-regulated transcription of 3-hydroxy-3-methylglutaryl coenzyme A synthase promoter

21 January 2018

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CBP is required for sterol-regulated and sterol regulatory element-binding protein-regulated transcription

21 January 2018

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YY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genes

21 January 2018

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Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER

21 January 2018

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ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose

21 January 2018

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Multiple mechanisms of transcriptional repression by YY1.

21 January 2018

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Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors.

21 January 2018

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Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis

21 January 2018

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SCAP ligands are potent new lipid-lowering drugs

21 January 2018

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Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles

21 January 2018

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Proteolysis and sterol regulation

21 January 2018

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Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells

21 January 2018

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

21 January 2018

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SREBPs: transcriptional mediators of lipid homeostasis

21 January 2018

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Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.

21 January 2018

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Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

21 January 2018

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Dietary polyunsaturated fatty acids and regulation of gene transcription

21 January 2018

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Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain

21 January 2018

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ADD1/SREBP1 activates PPARγ through the production of endogenous ligand

21 January 2018

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Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).

21 January 2018

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Four cholesterol-sensing proteins

21 January 2018

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Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

21 January 2018

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Cholesterol homeostasis: not until the SCAP lady INSIGs.

21 January 2018

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Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element

21 January 2018

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Different sterol regulatory element-binding protein-1 isoforms utilize distinct co-regulatory factors to activate the promoter for fatty acid synthase.

21 January 2018

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SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation

21 January 2018

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Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes

21 January 2018

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PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

21 January 2018

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Functional analysis of secreted and transmembrane proteins critical to mouse development.

21 January 2018

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Identification of mutations in the gene encoding sterol regulatory element binding protein (SREBP)-2 in hypercholesterolaemic subjects

21 January 2018

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Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro

21 January 2018

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Composite co-activator ARC mediates chromatin-directed transcriptional activation

21 January 2018

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Repression of the steroidogenic acute regulatory gene by the multifunctional transcription factor Yin Yang 1

21 January 2018

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DNA bending and orientation-dependent function of YY1 in the c-fos promoter.

21 January 2018

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Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone

21 January 2018

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Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain

21 January 2018

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Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi

21 January 2018

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Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes

21 January 2018

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Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.

21 January 2018

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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

21 January 2018

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Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

21 January 2018

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Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene

21 January 2018

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Role of LXRs in control of lipogenesis

21 January 2018

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Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

21 January 2018

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Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver

21 January 2018

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Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

21 January 2018

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Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

21 January 2018

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Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene

21 January 2018

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Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver

21 January 2018

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Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

21 January 2018

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Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

21 January 2018

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Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus

21 January 2018

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Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

21 January 2018

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The role of SREBP-1c in nutritional regulation of lipogenic enzyme gene expression

21 January 2018

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ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation

21 January 2018

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Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites

21 January 2018

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Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis

21 January 2018

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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

21 January 2018

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Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease

21 January 2018

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SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

21 January 2018

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Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

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Sterol Regulatory Element Binding Protein-1a Regulation of the Steroidogenic Acute Regulatory Protein Gene1

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/O03-090

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9 August 2017

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