Harnessing memory adaptive regulatory T cells to control autoimmunity in type 1 diabetes (Q35716720)

9 August 2017

title

Harnessing memory adaptive regulatory T cells to control autoimmunity in type 1 diabetes (English)

1 reference

9 August 2017

0 references

Cheng-Rui Li

1

1 reference

9 August 2017

Bas J G Baaten

series ordinal

2

1 reference

9 August 2017

Linda M Bradley

series ordinal

3

1 reference

9 August 2017

publication date

24 November 2011

1 reference

Journal of Molecular Cell Biology

9 August 2017

published in

1 reference

9 August 2017

volume

4

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9 August 2017

issue

1

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9 August 2017

page(s)

38-47

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Clinical perspectives for regulatory T cells in transplantation tolerance

9 August 2017

cites work

1 reference

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Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children

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Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.

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Characterization of protective human CD4CD25 FOXP3 regulatory T cells generated with IL-2, TGF-β and retinoic acid

12 July 2018

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12 July 2018

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PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors

12 July 2018

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Immunotherapy of type 1 diabetes: where are we and where should we be going?

12 July 2018

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Molecular targeting of islet autoantigens

12 July 2018

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Genomic definition of multiple ex vivo regulatory T cell subphenotypes

12 July 2018

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12 July 2018

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Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3 T cells in pancreatic lymph nodes

12 July 2018

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Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells.

12 July 2018

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Regulatory T cells exert checks and balances on self tolerance and autoimmunity

12 July 2018

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Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4( )CD25( ) regulatory T-cells of type 1 diabetic subjects

12 July 2018

1 reference

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T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event

12 July 2018

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Dominant role of antigen dose in CD4 Foxp3 regulatory T cell induction and expansion

12 July 2018

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Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

12 July 2018

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CD44 costimulation promotes FoxP3 regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta

12 July 2018

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Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

12 July 2018

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Foxp3 regulatory T cells: differentiation, specification, subphenotypes

12 July 2018

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Control of regulatory T cell lineage commitment and maintenance

12 July 2018

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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

12 July 2018

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Regulatory T cells enter the pancreas during suppression of type 1 diabetes and inhibit effector T cells and macrophages in a TGF-beta-dependent manner

12 July 2018

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Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses

12 July 2018

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Functional islet-specific Treg can be generated from CD4 CD25- T cells of healthy and type 1 diabetic subjects

12 July 2018

1 reference

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Analysis of islet inflammation in human type 1 diabetes.

12 July 2018

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The effector T cells of diabetic subjects are resistant to regulation via CD4 FOXP3 regulatory T cells

12 July 2018

1 reference

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Innate immunity and intestinal microbiota in the development of Type 1 diabetes

12 July 2018

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The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice

12 July 2018

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Retinoic acid increases Foxp3 regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression

12 July 2018

1 reference

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Polyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cells

12 July 2018

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How regulatory T cells work

12 July 2018

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Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

12 July 2018

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The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function

12 July 2018

1 reference

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Combination of rapamycin and IL-2 increases de novo induction of human CD4( )CD25( )FOXP3( ) T cells

12 July 2018

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Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

12 July 2018

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12 July 2018

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TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets

12 July 2018

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Rapid default transition of CD4 T cell effectors to functional memory cells

12 July 2018

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Induction of FOXP3 expression in naive human CD4 FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype

12 July 2018

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Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

12 July 2018

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A functionally specialized population of mucosal CD103 DCs induces Foxp3 regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism

12 July 2018

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Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid

12 July 2018

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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

12 July 2018

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Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment

12 July 2018

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Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3 T regulatory cells

12 July 2018

1 reference

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Dendritic cells with TGF-beta1 differentiate naive CD4 CD25- T cells into islet-protective Foxp3 regulatory T cells

12 July 2018

1 reference

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Epigenetic control of the foxp3 locus in regulatory T cells

12 July 2018

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FOXP3: not just for regulatory T cells anymore

12 July 2018

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Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

12 July 2018

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Type 1 diabetes genes and pathways shared by humans and NOD mice

12 July 2018

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Antigen processing by autoreactive B cells promotes determinant spreading

12 July 2018

1 reference

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A comprehensive review of interventions in the NOD mouse and implications for translation

12 July 2018

1 reference

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A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

12 July 2018

1 reference

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De novo generation of antigen-specific CD4 CD25 regulatory T cells from human CD4 CD25- cells

12 July 2018

1 reference

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Homeostatic maintenance of natural Foxp3( ) CD25( ) CD4( ) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

12 July 2018

1 reference

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Defective suppressor function in CD4( )CD25( ) T-cells from patients with type 1 diabetes.

12 July 2018

1 reference

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CD25 CD4 T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.

12 July 2018

1 reference

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Cutting edge: TGF-beta induces a regulatory phenotype in CD4 CD25- T cells through Foxp3 induction and down-regulation of Smad7

12 July 2018

1 reference

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TGF-beta regulates in vivo expansion of Foxp3-expressing CD4 CD25 regulatory T cells responsible for protection against diabetes

12 July 2018

1 reference

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Conversion of peripheral CD4 CD25- naive T cells to CD4 CD25 regulatory T cells by TGF-beta induction of transcription factor Foxp3

12 July 2018

1 reference

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Interleukin 7 regulates the survival and generation of memory CD4 cells

12 July 2018

1 reference

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Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes Model

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Regulatory T cells and dendritic cells in transplantation tolerance: molecular markers and mechanisms

12 July 2018

1 reference

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Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4 CD25– T cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

An epigenetic view of helper T cell differentiation

12 July 2018

1 reference

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Natural versus adaptive regulatory T cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Alpha E: no more rejection?

12 July 2018

1 reference

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The effect of infections on susceptibility to autoimmune and allergic diseases

12 July 2018

1 reference

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Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

In vitro generation of interleukin 10-producing regulatory CD4( ) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Multiple immuno-regulatory defects in type-1 diabetes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

The beta7 integrin gene (Itgb-7) promoter is responsive to TGF-beta1: defining control regions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry

12 July 2018

1 reference

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Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

A predominant role of integrin alpha 4 in the spontaneous development of autoimmune diabetes in nonobese diabetic mice

12 July 2018

1 reference

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Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4 and Lyt-2 T cells.

12 July 2018

1 reference

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A Protective Role of the Environment in the Development of Type 1 Diabetes?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Transforming growth factor-beta enhances the in vivo effector function and memory phenotype of antigen-specific T helper cells in experimental autoimmune encephalomyelitis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Quantitative events determine the differentiation and function of helper T cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Regulatory T cells prevent transfer of type 1 diabetes in NOD mice only when their antigen is present in vivo

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Cutting edge: Foxp3 CD4 CD25 regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Critical role of IL-2 and TGF-beta in generation, function and stabilization of Foxp3 CD4 Treg.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Cutting edge: high molecular weight hyaluronan promotes the suppressive effects of CD4 CD25 regulatory T cells

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

IL-2 is essential for TGF-beta to convert naive CD4 CD25- cells to CD25 Foxp3 regulatory T cells and for expansion of these cells

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Rapamycin promotes expansion of functional CD4 CD25 FOXP3 regulatory T cells of both healthy subjects and type 1 diabetic patients

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Peptide-pulsed immature dendritic cells reduce response to beta cell target antigens and protect NOD recipients from type I diabetes.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

ADA Outstanding Scientific Achievement Lecture 2004. Thirty years of investigating the autoimmune basis for type 1 diabetes: why can't we prevent or reverse this disease?

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Natural and induced CD4 CD25 cells educate CD4 CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Generation ex vivo of TGF-beta-producing regulatory T cells from CD4 CD25- precursors.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

CD4( ) T cell effectors can become memory cells with high efficiency and without further division.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Involvement of β7 Integrin and Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1) in the Development of Diabetes in Nonobese Diabetic Mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3 regulatory T cells

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Transient expression of FOXP3 in human activated nonregulatory CD4 T cells

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269299

Increased resistance to CD4 CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes

15 November 2018

1 reference

12 December 2020

Generation and expansion of regulatory human CD4( ) T-cell clones specific for pancreatic islet autoantigens

1 reference

12 December 2020

Functional defects and the influence of age on the frequency of CD4 CD25 T-cells in type 1 diabetes

1 reference

12 December 2020

Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo

1 reference

12 December 2020

No alterations in the frequency of FOXP3 regulatory T-cells in type 1 diabetes

1 reference

12 December 2020

A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-beta

1 reference

12 December 2020

Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy

1 reference

12 December 2020

Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells

1 reference

12 December 2020

Withdrawal of stimulation may initiate the transition of effector to memory CD4 cells

1 reference

12 December 2020

Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case-control study

1 reference

12 December 2020

The pancreatic islets in diabetes

1 reference

12 December 2020

Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic non-obese diabetic (NOD) mice: a longitudinal study

1 reference

12 December 2020

Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4 and CD8 T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors

1 reference

12 December 2020

CD4 CD25high regulatory T cells in human autoimmune diabetes

1 reference

12 December 2020

Sub-optimal CD4 T-cell activation triggers autonomous TGF-β-dependent conversion to Foxp3 regulatory T cells

1 reference

12 December 2020

Identifiers

DOI

10.1093/JMCB/MJR040

1 reference

9 August 2017

1 reference

9 August 2017

1 reference