ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat. (Q35695410)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25872941 AND SRC:MED&resulttype=core&format=json

5 March 2020

title

ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat (English)

1 reference

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5 March 2020

14

1 reference

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5 March 2020

Tobias Keck

15

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5 March 2020

author name string

Simone Meidhof

1

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5 March 2020

Simone Brabletz

2

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5 March 2020

Waltraut Lehmann

3

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5 March 2020

Bogdan-Tiberius Preca

4

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5 March 2020

Kerstin Mock

5

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5 March 2020

Manuel Ruh

6

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5 March 2020

Julia Schüler

7

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5 March 2020

Maria Berthold

8

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5 March 2020

Anika Weber

9

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5 March 2020

Ulrike Burk

10

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5 March 2020

Michael Lübbert

11

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5 March 2020

Martin Puhr

12

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5 March 2020

Zoran Culig

13

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5 March 2020

Peter Bronsert

16

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5 March 2020

Simon Küsters

17

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5 March 2020

Ulrich T Hopt

18

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5 March 2020

Marc P Stemmler

19

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5 March 2020

Thomas Brabletz

20

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5 March 2020

publication date

1 June 2015

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5 March 2020

published in

EMBO Molecular Medicine

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volume

7

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issue

6

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5 March 2020

page(s)

831-847

1 reference

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ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance

5 March 2020

cites work

1 reference

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Oncogenic roles of EMT-inducing transcription factors

12 July 2018

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Cancer drug resistance: an evolving paradigm

12 July 2018

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Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties.

12 July 2018

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Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma

12 July 2018

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Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity

12 July 2018

1 reference

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hsa-miR-203 enhances the sensitivity of leukemia cells to arsenic trioxide

12 July 2018

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The prognostic value of microRNAs varies with patient race/ethnicity and stage of colorectal cancer

12 July 2018

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Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state

12 July 2018

1 reference

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Epithelial-to-mesenchymal transition leads to docetaxel resistance in prostate cancer and is mediated by reduced expression of miR-200c and miR-205.

12 July 2018

1 reference

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Cancer drug pan-resistance: pumps, cancer stem cells, quiescence, epithelial to mesenchymal transition, blocked cell death pathways, persisters or what?

12 July 2018

1 reference

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MicroRNA-203 suppresses cell proliferation and migration by targeting BIRC5 and LASP1 in human triple-negative breast cancer cells

12 July 2018

1 reference

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Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells

12 July 2018

1 reference

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Evolutionary functional analysis and molecular regulation of the ZEB transcription factors

12 July 2018

1 reference

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MicroRNA-203 leads to G1 phase cell cycle arrest in laryngeal carcinoma cells by directly targeting survivin

12 July 2018

1 reference

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Anti-miR-203 Upregulates SOCS3 Expression in Breast Cancer Cells and Enhances Cisplatin Chemosensitivity

12 July 2018

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EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers

12 July 2018

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A decade of exploring the cancer epigenome — biological and translational implications

12 July 2018

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Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis

12 July 2018

1 reference

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Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating–cancer stem cells: distinct, overlapping or same populations

12 July 2018

1 reference

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Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

12 July 2018

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The cancer stem cell: premises, promises and challenges

12 July 2018

1 reference

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Histone deacetylase inhibitor MGCD0103 synergizes with gemcitabine in human pancreatic cells

12 July 2018

1 reference

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microRNA‐203 suppresses bladder cancer development by repressing bcl‐w expression

12 July 2018

1 reference

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Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis

12 July 2018

1 reference

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Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases

12 July 2018

1 reference

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The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer?

12 July 2018

1 reference

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MicroRNA-203 expression as a new prognostic marker of pancreatic adenocarcinoma.

12 July 2018

1 reference

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The role of the miR-200 family in epithelial-mesenchymal transition

12 July 2018

1 reference

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EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

12 July 2018

1 reference

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Epithelial-mesenchymal transitions in development and disease

12 July 2018

1 reference

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The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

12 July 2018

1 reference

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Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells

12 July 2018

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Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells

12 July 2018

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Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer

12 July 2018

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Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival

12 July 2018

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A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival

12 July 2018

1 reference

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MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents

12 July 2018

1 reference

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Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

12 July 2018

1 reference

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The transcription repressor, ZEB1, cooperates with CtBP2 and HDAC1 to suppress IL-2 gene activation in T cells

12 July 2018

1 reference

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miRNA in situ hybridization in formaldehyde and EDC-fixed tissues

12 July 2018

1 reference

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Tissue microarrays of human tumor xenografts: characterization of proteins involved in migration and angiogenesis for applications in the development of targeted anticancer agents.

12 July 2018

1 reference

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miR-203 represses 'stemness' by repressing DeltaNp63

12 July 2018

1 reference

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A skin microRNA promotes differentiation by repressing 'stemness'.

12 July 2018

1 reference

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Differential control of Wnt target genes involves epigenetic mechanisms and selective promoter occupancy by T-cell factors

12 July 2018

1 reference

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Specificity, duplex degradation and subcellular localization of antagomirs

12 July 2018

1 reference

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Opposing LSD1 complexes function in developmental gene activation and repression programmes

12 July 2018

1 reference

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Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition

12 July 2018

1 reference

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A Method for Testing for Synergy with Any Number of Agents

12 July 2018

1 reference

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MicroRNA-203 down-regulation is associated with unfavorable prognosis in human glioma

12 July 2018

1 reference

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miR-203 inhibits proliferation of HCC cells by targeting survivin

25 September 2018

1 reference

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The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells.

25 September 2018

1 reference

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MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

25 September 2018

1 reference

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Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459821

Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459821

miR-203 reverses chemoresistance in p53-mutated colon cancer cells through downregulation of Akt2 expression

7 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25872941

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25872941

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.15252/EMMM.201404396

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25872941 AND SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25872941 AND SRC:MED&resulttype=core&format=json

5 March 2020

PubMed publication ID

25872941

1 reference